Acute Effects of TCIG vs ECIG in PLWH

University of California, Los Angeles37 enrolled

Overview

Randomized controlled trial of acute use of electronic cigarette or tobacco cigarette on parameters of ventricular repolarization and inflammation/oxidative stress.

On separate days, participants will undergo 3 different exposures: an acute e-cigarette exposure, an acute tobacco cigarette exposure, and a sham (empty e-cigarette) control . Before and after the acute exposure, participants will have blood drawn for inflammation/oxidative stress markers and undergo a 5-minute ECG recording.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

E Cigarette Use Vaping Smoking Tobacco Smoking Nicotine Use Disorder Qt Interval, Variation in HIV I Infection Oxidative Stress Inflammation

Interventions

TCIGOTHER

Use a TCIG

ECIGOTHER

Use an ECIG

sham controlOTHER

Use a sham control (empty ECIG)

Eligibility

Sex: ALLMin age: 21 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: Chronic (\> 1year) TCIG smoker HIV positive Stable ART Viral count non-detectable CD4 \>500 Exclusion Criteria: Known major illness (heart disease, diabetes, lung or liver disease) Daily recreational drug use, including cannabis \>2 alcoholic drinks per day Obesity (\>30 kg/m2) Recent (\<3 months) infection

Locations (2)

UCLA

Los Angeles, California, United States

UCaliforniaLA

Los Angeles, California, United States