The aim of this nationwide, observational cohort study is to evaluate current surveillance strategies after primary resection of pancreatic ductal adenocarcinoma (PDAC) in the Netherlands, with regard to the detection, treatment and survival of PDAC recurrence.
Study Type
OBSERVATIONAL
Enrollment
1,750
UMC Utrecht
Utrecht, Netherlands
RECRUITINGIncidence of PDAC recurrence
Incidence of PDAC recurrence within the Netherlands; PDAC recurrence is either pathologically proven, or suspected through cross-sectional imaging, preferably confirmed by consensus during a multidisciplinary meeting.
Time frame: Within a follow-up period up to 5 years
Patterns of PDAC recurrence
* Asymptomatic vs. symptomatic: Symptomatic recurrence is defined as the presence of symptoms suggestive for PDAC recurrence at recurrence diagnosis. If PDAC recurrence is detected in absence of suspected symptoms, disease recurrence was defined as asymptomatic. * First site of recurrence: isolated local recurrence, liver-only, lung-only, multiple-site, other isolated distant * Early vs. late recurrence: disease-free survival ≥12 months vs. \<12 months
Time frame: Within a follow-up period up to 5 years
Treatment of PDAC recurrence
Either systemic and/or local treatment or best-supportive-care
Time frame: Within a follow-up period up to 5 years
Survival
Overall survival (from the time of resection), disease-free survival (from the time of resection), post-recurrence survival (from the time of recurrence diagnosis)
Time frame: Within a follow-up period up to 5 years
Presence of symptoms at time of (suspected) recurrence
Which symptoms are associated with PDAC recurrence?
Time frame: Within a follow-up period up to 5 years
Performance score at time of recurrence detection
What is the ECOG performance score of patients at time of recurrence diagnosis?
Time frame: Within a follow-up period up to 5 years
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Use of imaging procedures during follow-up
How much imaging procedures are performed during postoperative follow-up for the detection of PDAC recurrence? Are these procedures routinely performed?
Time frame: Within a follow-up period up to 5 years
Number of histologically confirmed recurrences
How often is PDAC recurrence histologically confirmed?
Time frame: Within a follow-up period up to 5 years