This study aims to evaluate the pharmacokinetic (PK) interaction between tegoprazan and non-steroidal anti-inflammatory drugs (NSAIDs) after given each alone and in their combination in healthy male adults.
A randomized, open-label, multiple-dose, 6-sequence-arm, 3-period cross-over study
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
60
Tegoprazan 50 mg tablet
Naproxen 500 mg tablet
Aceclofenac 100 mg tablet
Chonbuk National University Hospital
Jeonju, South Korea
AUCτ of tegoprazan and NSAIDs
Area under the plasma concentration-time curve during a steady-state dosing interval (τ) of tegoprazan and NSAIDs
Time frame: pre-dose (0 hour) on Day1, Day5, Day6 and pre-dose up to 24 hours post-dose on Day7
Css,max of tegoprazan and NSAIDs
Maximum Plasma Concentration at Steady State of tegoprazan and NSAIDs
Time frame: pre-dose (0 hour) on Day1, Day5, Day6 and pre-dose up to 24 hours post-dose on Day7
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