Total Neoadjuvant Treatment Plus PD-1 in Mid-Low Locally Advanced Rectal Cancer

Inclusion Criteria: 1. The patients and their families are able to understand and are willing to participate in this clinical study, and sign an informed consent form. 2. Age: 18\~80 years old, no gender limit; 3. Pathologically diagnosed rectal adenocarcinoma: differentiated into Grade 1-3, that is, high, medium, and poorly differentiated tubular adenocarcinoma; 4. The initial MRI partial phases are: 1) Local intermediate risk: T3c/d or N1-2 (carcinoma nodules) or very low position or EMVI+ or MRF 1-2mm, without external iliac, total iliac, obturator, main abdomen Arterial lymph node metastasis; 2) Local high risk: T4 or MRF+ or lateral lymph node positive. 5. The distance from the lower edge of the tumor is below the reflex of the peritoneum (MRI evaluation); 6. No distant transfer; 7. ECOG PS score 0-1 within 7 days before the first medication; 8. Hepatitis B Surface Antigen (HBsAg) (-) and Hepatitis B Core Antibody (HBcAb) (-). If HBsAg (+) or HBcAb (+), hepatitis B virus deoxyribonucleic acid (HBV-DNA) must be less than 1000 copies/mL or 200 IU/mL before entering the group. 9. HCV antibody (-) 10. The main organ function is normal. 11. No history of pelvic radiotherapy; 12. No history of rectal cancer surgery or chemotherapy; 13. Not accompanied by systemic infections requiring antibiotic treatment; 14. Heart, lung, liver, and kidney functions can tolerate surgery; 15. Others, based on the results of previous medical history, vital signs, physical examination or laboratory examination, the research doctor judges that you are suitable for participating in this clinical study. Exclusion Criteria: 1. Recurrent rectal cancer; 2. The patient cannot tolerate enhanced nuclear magnetic examination; 3. Patients who are planning to undergo or have previously received organ or bone marrow transplantation; 4. Myocardial infarction or poorly controlled arrhythmia (including QTc interval ≥ 450 ms for males and ≥ 470 ms for females) occurred within 6 months before the first medication (QTc interval is calculated by Fridericia formula); 5. Existence of NYHA standard grade III to IV cardiac insufficiency or color Doppler ultrasound examination: LVEF (left ventricular ejection fraction) \<50%; 6. Human immunodeficiency virus (HIV) infection; 7. Suffer from active tuberculosis; 8. Past and present patients with interstitial pneumonia, pneumoconiosis, radiation pneumonia, drug-related pneumonia, severely impaired lung function, etc., which may interfere with the detection and treatment of suspected drug-related lung toxicity; 9. There is a known active or suspicious autoimmune disease. Except those who were in a stable state of the disease at the time of enrollment (no need for systemic immunosuppressive therapy); 10. Received treatment with live vaccines within 28 days before the first administration; except for inactivated viral vaccines for seasonal influenza; 11. Patients who need to receive systemic corticosteroids (\> 10 mg/day curative dose of prednisone) or other immunosuppressive drugs within 14 days before the first medication or during the study period. However, the following conditions are allowed to enter the group: in the absence of active autoimmune diseases, patients are allowed to use topical or inhaled steroids, or adrenal hormone replacement therapy with a dose ≤ 10 mg/day prednisone curative dose; 12. Any active infection that requires systemic anti-infective treatment occurs within 14 days before the first administration; except for receiving preventive antibiotic treatment (such as preventing urinary tract infection or chronic obstructive pulmonary disease); 13. Have received other antibody/drug treatments against immune checkpoints in the past, such as PD-1, PD-L1, CTLA4, etc.; 14. Known to have a history of severe allergies to any monoclonal antibody or research drug excipients; 15. In the past 5 years, patients have suffered from malignant tumors whose survival rate is significantly lower than the historical data of our rectal cancer survival rate (properly treated basal cell carcinoma, skin squamous cell carcinoma, small kidney cancer, breast cancer, and papillary thyroid carcinoma are not included here. range); 16. The patient has had arterial embolism diseases in the past 6 months, such as angina pectoris, MI, TIA, CVA, etc.; 17. Have received other types of anti-tumor or experimental treatments; 18. The patient is a female during pregnancy or lactation; 19. The patient has other diseases or abnormal mental states, which may affect the patient's participation in this study; 20. There are patients who may increase the risk of participating in research and research medication, or other severe, acute and chronic diseases, who are not suitable for clinical research based on the judgment of the investigator.