Absorption and Digestion Kinetics of Human Metabolites

Inclusion Criteria: * Age: 20-40 years old to constitute a young study population * BMI: 19-27 kg/m2 to constitute a normal/healthy weight population * Weight: 133lbs or more * Subjects must be willing and able to consume a standardized breakfast bar containing cashews and dates (Larabar). * Subjects must be willing to consume oral dietary supplement versions of spermidine, 1-methlynicotinamide, palmitoylethanolamide, and oleoylethanolamide. * Subjects must be willing and able to undergo blood draws at the UC Davis Ragle Nutrition Center at 0, 1, 2, and 4 hours after supplementation with spermidine, niacinamide, palmitoylethanolamide, and oleoylethanolamide. Exclusion Criteria: * Smoker * Anemia * Documented chronic diseases including diabetes, thyroid disease, metabolic syndrome, cancer, autoimmune diseases, or previous cardiovascular events * Any inflammatory bowel disease including IBS, Crohn's Disease, Celiac Disease * Any allergy or sensitivity to wheat, gluten, or soy products * Consumption of \>1 alcoholic drink/day * Current consumption of any probiotic, prebiotic, or dietary supplements * Extreme dietary or exercise patterns * Recent weight fluctuations (greater than 10% in the last six months) * Regular use of over-the-counter allergy or pain medications (\>1/week) * Taking prescription lipid medications (e.g. statins) or other supplements known to alter lipoprotein metabolism such as isoflavones. * Use of any form of hormonal birth control including oral contraception pills, hormonal IUDs or rings, or hormonal birth control patches * Illness such as flu or cold of any kind within the last two weeks * Allergy to components of standardized breakfast bar (cashew/dates) * Changes to any of the above during the study period.