Study to Evaluate HT-6184 in Healthy Subjects

Inclusion Criteria: 1. Is male or female, between 18 and 65 years of age (inclusive) at Screening; 2. Has a body mass index (BMI) between 18.0 and 32.0 kg/m2 (inclusive) at Screening 3. Is in good general health, as determined by the Investigator, without clinically significant medical history; 4. Normal physical examination, 12-lead electrocardiogram (ECG), and vital signs, as determined by the Investigator; 5. Clinical laboratory values within the normal limits as defined by the clinical laboratory reference range; 6. Female partners of male participants of childbearing potential, and female participants of childbearing potential must agree to use a highly effective method of contraception prior to study entry, for the duration of study participation, and a minimum of 30 days after the last dose. Highly effective forms of contraception include the following: * Established use (i.e., at least 30 days prior to enrollment) of combined (estrogen and progestogen containing) oral, intravaginal or transdermal hormonal contraception associated with inhibition of ovulation, * Established use (i.e., at least 30 days prior to enrollment) progestogen-only oral, injectable or implantable hormonal contraception associated with inhibition of ovulation, * Established use (i.e., at least 30 days prior to enrollment) of an intrauterine device (IUD) or intrauterine hormone-releasing system (IUS), * bilateral tubal occlusion, * vasectomized partner, provided that partner is the sole sexual partner of the female trial participant and that the vasectomized partner has received medical assessment of the surgical success, * sexual abstinence, defined as refraining from heterosexual intercourse during the study, when this is in line with the preferred and usual lifestyle of the subject. 7. In the case of a female of childbearing potential, has a negative serum pregnancy test (SPT) at Screening and Day -2 and is willing to submit to a SPT at the end of study (EOS); 8. Negative urine test for drugs of abuse and breath test for alcohol use at Screening and check-in (Day -2). The tests may be repeated once if necessary and deemed appropriate by the Investigator; 9. Agree to refrain from tobacco or nicotine containing products within 48 hours prior to Day 1 and during the periods when PK blood samples are collected; 10. Agree to refrain from alcohol consumption within 48 hours prior to Day 1 and during the periods when PK blood samples are collected; 11. Agree to refrain from caffeine (i.e., coffee, tea, caffeinated soda, chocolate) within 48 hours prior to Day 1 and during the periods when PK blood samples are collected; 12. Agree to refrain from grapefruit, Seville oranges, and pomelo containing products within 72 hours prior to Day 1 and during the periods when PK blood samples are collected; and 13. Read, understand, and sign an informed consent. Exclusion Criteria: 1. A female who is pregnant, plans to become pregnant during the study, or is breastfeeding a child; 2. Any clinically significant central nervous system, cardiac, pulmonary, renal, gastrointestinal (GI), endocrinological, respiratory, or metabolic conditions (or history), or other pathological or physiological conditions, that might interfere with the study results in the investigator's opinion; 3. Any condition which, in the investigator's opinion, puts the participant at significant risk, could confound the study results, or may interfere significantly with the subject's participation in the study; 4. Immunization within 10 days of Day 1; 5. Anticipated need for surgery or hospitalization during the study; 6. Consumed alcohol within 48 hours prior to Day 1 or refuses to abstain from alcohol throughout the duration of the study; 7. History of heavy smoking (i.e., more than 10 cigarettes a day or the tobacco/nicotine equivalent) within 3 months of screening or refuses to abstain from tobacco or nicotine-containing products throughout the duration of the study; 8. Donation or loss of blood (excluding volume drawn at screening) of ≥ 450 mL within 3 months of Day 1; 9. Active or lifetime infection (e.g., negative test for human immunodeficiency virus (HIV) and hepatitis, and no history of tuberculosis and syphilis) or a history of severe infection during the 30 days prior to screening; 10. Chronic or current active infectious disease requiring systemic antibiotics, antifungal, or antiviral treatment; 11. Prior treatment with a NLRP3 inhibitor for any indication; 12. Is unwilling or unable to refrain from using prescription medications for 30 days prior to Day 1 or over the counter medications, herbal preparations, and supplements for 14 days prior to Day 1 (excluding permitted forms of contraception and occasional use of acetaminophen \[up to 2 g in 24 hours\]); 13. Inability or unlikeliness of the participant to comply with the dose schedule and study evaluations, in the opinion of the investigator; 14. Is currently participating in any clinical trial; 15. Has received any investigational drug(s) within 30 days or 5 half-lives, whichever is longer, prior to study Day 1; 16. Any condition that would, in the investigator's judgment, interfere with full participation in the study, including attending required study visits; pose a significant risk to the participant; or interfere with interpretation of study data; and/or 17. Inability of the participant (or legally authorized representative) to comprehend the informed consent form (ICF) or unwillingness to sign the ICF.