Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain

Inclusion Criteria: * Patients of both sexes aged from 18 to 40 years. * Patients who agreed to participate in the study by signing the informed consent. * Patients with indication for surgical extraction of impacted lower third molars according to the Pell and Gregory classification. * Healthy subjects or with history of controlled chronic non-communicable diseases or that can be controlled prior to surgery, which, in the investigator's opinion, do not represent an additional risk for the patient. * Patients who, at the investigator's discretion, meet personal and family conditions that allow them to properly comply with the activities described in the protocol and adherence to treatment. Exclusion Criteria: * Findings in the clinical history, vital signs, physical examination or laboratory studies suggesting abnormal conditions which represent a risk for subject's health at the investigator´s discretion. * Hypersensitivity to any of the active ingredients and/or excipients of the investigational drugs. * Patients with active peptic or gastroduodenal ulcer or diagnosis 30 days prior to signing the informed consent. * Patients with history of allergic asthma reactions. * Patients with severe hepatic dysfunction, classified as Child Pugh C or when being less, the investigator considers it an additional risk for patients. * Patients with a creatinine clearance \<30 mL/min. * Patients with coagulation disorders. * Patients with Systemic Lupus Erythematosus. * Patients with congestive heart failure (NYHA class II-IV), ischemic heart disease, peripheral arterial disease, or cerebrovascular disease who have recently (3 months) undergone coronary artery bypass grafting or angioplasty procedures. * Patients at high risk of acute cardiovascular events (intense smoking, hypertension or uncontrolled diabetes mellitus). * Patients with a history of systemic neoplastic diseases or under treatment with chemotherapy. * Patients with a history of illicit drug abuse or addiction to alcohol or tobacco. * Patients with monoamine oxidase inhibitors (MAOIs) treatment or during the last 2 weeks prior to the study drug administration. * Patients with opioid analgesics, neuromodulators, or long-acting NSAIDs therapy who, according to medical criteria, cannot carry out a withdrawal scheme for at least five half-lives prior to surgery. * Patients with history of seizures or who are under treatment with medications that reduce the seizure threshold and who, according to medical criteria, cannot carry out a withdrawal scheme within 30 days prior to surgery. * Positive pregnancy test or lactating women. * Positive rapid urine drug test.