The Effectiveness of 3% Topical Tranexamic Acid Compared to 4% Topical Hydroquinone as Therapy of Melasma

Inclusion Criteria: * Female patients diagnosed with melasma. * 18-60 years old. * Fitzpatrick skin type III to V. * Willing to be a research subject (SP) and sign a consent sheet. research (informed consent). Exclusion Criteria: * Are pregnant and/or breastfeeding * History of taking hormonal contraceptives in the last 6 months * History of topical melasma therapy: corticosteroids, tretinoin, hydroquinone, and Another therapy that lightens the skin in the last 2 weeks. * Use oral systemic therapy or injection in melasma, such as oral acid tranexamic, oral antioxidant, vitamin C injection, and glutathione injection in 4 last week. * History of superficial peeling therapy in the last 4 weeks. * History of deep peeling, laser or mechanical abrasion therapy in the last 6 months. * Use drugs that are photosensitizers such as phenytoin, tetracycline, spironolactone, and carbamazepine. * History of bleeding disorders or being on blood-thinning therapy * Allergy to tranexamic acid * Difficulty in complying with treatment. * Are experiencing symptoms of COVID-19, such as fever, cough, sore throat, loss of sense of taste or smell, red eyes, diarrhea, rash on the skin