Neostigmine Versus Sugammadex on Renal Functions

Menoufia University64 enrolled

Overview

The study will assess the acute effects of sugammadex or neostigmine on renal function as determined with more specific and sensitive tests in laparoscopic cholecystectomy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

DOUBLE

Enrollment

Conditions

Sugammadex Neostigmine

Interventions

NeostigmineDRUG

a combination of 0.04 mg/kg neostigmine with 0.01 mg/kg atropine intravenously at the reappearance of a second twitch of TOF after the last dose of rocuronium

SugammadexDRUG

2-4 mg/kg sugammadex intravenously upon the reappearance of a post-tetanic count 1-2 or a second twitch of TOF after the last dose of rocuronium

Eligibility

Sex: ALLMin age: 20 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * normal renal function (serum Cr 0.4- 1.4 g/dL) * American Society of Anesthesiologists (ASA) Class I-II Exclusion Criteria: * Incapacity to consent. * Pre-existing impaired kidney functions. * Severe neuromuscular disease, as: myasthenia gravis \& muscular dystrophy. * Intra-operative bleeding * Lengthy operations that exceed 2 hours. * Hemodynamic changes more than 20% of the base line

Locations (1)

Menoufia University Hospitals

Shibīn al Kawm, Menoufia, Egypt

Outcomes

Primary Outcomes

neutrophil gelatinase associated lipocalin (NGAL) values

normal overall unisex value 47-55 ng/ml

Time frame: baseline ( 2 days preoperative) and 12 hours after surgery

Data from ClinicalTrials.gov

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