The purpose of this study is to evaluate the effectiveness and mechanism of action of Losartan in the treatment of coarctation of aorta.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Enrollment
120
50mg administered orally once daily for 52 weeks.
5mg Amlodipine administered orally once daily for 52 weeks.
Oral capsules that contain no active drug ingredients administered orally once daily for 52 weeks.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
RECRUITINGChange in Left Ventricular (LV) Fibrosis
LV fibrosis will be measured via indexed Extracellular Volume (iECV) which will be calculated as extracellular volume fraction (ECV%) x LV End Diastolic Volume Index as evaluated during Cardiac Magnetic Resonance Imaging (CMRI).
Time frame: Baseline; Week 52
Change in Exercise Capacity (peak VO2)
Change in Exercise Capacity will be evaluated based on peak VO2, measured as milliliters of oxygen per kilogram of body weight per minute (ml/kg/min), during supine bike cardiopulmonary exercise test (Stress Echocardiogram).
Time frame: Baseline; Week 52
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.