Evaluation of Efficacy and Safety of VX-548 for Painful Lumbosacral Radiculopathy (PLSR)

Key Inclusion Criteria: * Body weight greater than or equal to (\>=)45 kilogram (kg) * Body mass index (BMI) less than or equal to (\<=) 40 kg/ meter square (m\^2) * Diagnosis of PLSR for greater than (\>)3 months as per criteria pre-specified in the protocol * Weekly average of daily NPRS score \>=4 and \<10 with limited variation in the 7-day Run-in Period Key Exclusion Criteria: * More than 3 missing daily NPRS scores during the 7-day Run-in Period * Moderate or severe painful neuropathy other than PLSR as pre-specified in the protocol * History of prior lumbar spine surgery (e.g., discectomies, laminectomies, foraminotomies, or fusion) Other protocol defined Inclusion/Exclusion criteria may apply.