Clinical Trial for Non-inferiority and Safety of Tenofovir Alafenamide and Tenofovir Disoproxil Fumarate in Patients With Hematologic Malignancies Who Require Prophylactic Hepatitis B Antiviral Treatment

Inclusion Criteria: 1. Adult men and women over 19 years of age and under 65 years of age 2. Patients who meet the following criteria A or B A. Those scheduled for hematopoietic stem cell transplantation and treatment with immunosuppressants or chemotherapy. B. Those scheduled to receive anticancer treatment including rituximab 3. HBcAb positive patient 4. Patients who voluntarily agreed to participate in this clinical trial and signed a written consent form Exclusion Criteria: 1. Patients taking oral chronic hepatitis B antiviral drugs before starting the study 2. Galactose intolerance. Patients with genetic problems such as Lapp lactase deficiency or glucose-galactose malabsorption 3. Patients with hypersensitivity to tenofovir alafenamide citrate or tenofovir disoproxil orotate 4. Patients with abnormal renal function (e-GFR less than 15mL/min) or end-stage renal disease requiring dialysis 5. Hepatitis C patients 6. HIV-infected patients 7. Pregnant women, lactating women, or patients planning to become pregnant 8. If you are participating in another clinical trial administering medication 9. Patients who do not agree to participate in this clinical trial 10. Adults with impaired consent capacity who are unable to give consent on their own 11. Those who have taken other clinical trial drugs for less than 24 weeks 12. Other clinically determined by the principal investigator to be difficult for the clinical trial subject to conduct the clinical trial.