Empagliflozin and Red Blood Cell 2,3-biphosphoglycerate Levels

Inclusion Criteria: Patients\>18 year-old and at least one of the following * Type 2 Diabetes Mellitus and HbA1c: 6.5-9.0% or HbA1c \<6.5% and history of Coronary Artery Disease or Stroke not treated with GLP-1RA * Heart Failure defined as Ejection Fraction\<40% or NT-proBNP\>300pg/ml or Atrial fibrillation and NT-proBNP\>900pg/ml * Chronic Kidney Disease defined as eGFR\<60ml/min/1.73m2 (CKPD- EPI) or/and UACR\>200mg/g Initiating treatment with empagliflozin 10mg once daily as add on treatment Exclusion Criteria: * Patients already treated with an SGLT-2 inhibitor * Patients with Hb\<11gr/dl or\>16gr/dl * Patients with history of inherited or acquired hemoglobin disease * Patients with history of hemolytic anemia * Patients with history of hematologic malignancy or myelodysplastic syndrome or myeloproliferative syndrome * Patients treated within the last 6 months for anemia due to iron, B12 or folate deficiency * Patients with history of major hemorrhage or major operation leading to RBC transfusion within the last 3 months. * Patients planning major operation or revascularization procedure within the 12 following weeks * Patients treated with erythropoietin * Patients with Chronic Kidney Disease and GFR\<30ml/min/1.73m2 * Pregnancy * Women of childbearing age not receiving appropriate contraception measures