This prospective study assesses the pulmonary and cardiovascular effets of vaping in adult electronic cigarette users with biannual visits and a 5-year follow-up.
Daily vaping device users will be recruited in the Quebec City metropolitan area. Subjects will be asked to perform pulmonary function tests (spirometry, oscillometry, plethysmography, methacholine provocation) every 6 months for a 5-year follow up. Subjects will also answer a questionnaire assessing their vaping, tobacco and cannabis smoking habits, as well as their perceived respiratory symptoms. Blood draws and sputum inductions will be performed for cell counts and to measure inflammation markers.
Study Type
OBSERVATIONAL
Enrollment
250
Participants use their vaping products at their own discretion and their intake is monitored via questionnaires.
IUCPQ-UL
Québec, Canada
RECRUITINGNumber of participants who vape daily with impaired lung volumes.
Participants will perform plethysmography assessments to measure changes in lung volumes. Data will be expressed as a percentage of predicted values.
Time frame: Every 6 months for 5 years
Number of participants who vape daily with impaired lung diffusion capacity.
Participants will perform diffusion capacity of the lung for carbon monoxide (DLCO) measures to assess changes in lung diffusion capacity. Data will be expressed as a percentage of predicted values.
Time frame: Every 6 months for 5 years
Number of participants who vape daily with impaired spirometry.
Participants will perform spirometry tests measures to assess changes in forced expiratory lung volumes. Data will be expressed as a percentage of predicted values.
Time frame: Every 6 months for 5 years
Number of participants who vape daily with airway hyperresponsiveness.
Participants will perform methacholine provocation challenge measures to assess changes in airway hyperresponsiveness. Data will be expressed as the methacholine concentration inducing a fall of 20% of forced expiratory volume in the first second assessed (PC20).
Time frame: Every 6 months for 5 years
Number of participants who vape daily with changes in blood cell count.
Participants will perform a blood draw to assess blood cell count. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count.
Time frame: Every 6 months for 5 years
Number of participants who vape daily with changes in sputum cell count.
Participants will perform sputum inductions to assess cell count in the sputum. Data will be expressed as a percentage of eosinophils, neutrophils, macrophages and lymphocytes of the total cell count.
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Time frame: Every 6 months for 5 years
Vaping, tobacco and cannabis smoking habits of participants.
Participants will complete questionnaires assessing their vaping habits, tobacco smoking and cannabis smoking history.
Time frame: Every 3 months for 5 years