Losartan Use to Mitigate Arthrofibrosis Following Total Joint Arthroplasty

NYU Langone Health

Overview

The purpose of this study is to determine the effect of Losartan, an Angiotensin II Receptor Blocker (ARB), on the formation development of arthrofibrosis in patients who have had a primary total knee arthroplasty. This study aims to assess the post-operative range of motion and the incidence of MUA within three months following the index arthroplasty in the treatment arm (losartan) and the control arm.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Arthrofibrosis of Knee

Interventions

LosartanDRUG

Patients will receive Losartan 12.5mg orally twice daily beginning 2 weeks preoperatively and continuing for 4 weeks postoperatively.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients are candidates for elective primary total knee arthroplasty for a diagnosis of osteoarthritis or inflammatory arthritis. 2. Patients ≥18 years of age 3. Patients have been medically cleared and scheduled for surgery 4. Patients' primary care physician has verified that the patient can safely take the described dose of Losartan for the duration of the study period. Exclusion Criteria: 1. Patients already taking Losartan will not be included in the prospective study 2. Patients already taking an ARB (angiotensin receptor blockers) or other ACE (Angiotensin-converting-enzyme) inhibitor 3. Low blood pressure 4. Currently taking hypertensive medication 5. Revision surgery 6. Surgery for fracture, infection, or malignancy 7. Patients with a diagnosis of post-traumatic arthritis 8. Bilateral, simultaneous surgery

Locations (1)

NYU Langone Health

New York, New York, United States

Outcomes

Primary Outcomes

Change in range of motion

Time frame: Baseline, Day 90

Rate of manipulation under anesthesia (MUA) after elective total knee arthroplasty

Time frame: Day 90

Data from ClinicalTrials.gov

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