Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

University of Bonn720 enrolled

Overview

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Acronym: Expansion: HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase

Study Type

OBSERVATIONAL

Enrollment

720

Conditions

Hypophosphatasia

Interventions

Second alkaline phosphatase measurementDIAGNOSTIC_TEST

(1-4 weeks after the 1st measurement)

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Written informed consent * Age \> 18 years * Clinical suspicion of hypophosphatasia * Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening Exclusion Criteria: * Failure to meet the inclusion criteria listed above

Locations (1)

Clinic of Internal Medicine III, Department of Oncology, Haematology, Rheumatology and Clinical Immunology, University Hospital Bonn

Bonn, North Rhine-Westphali, Germany

RECRUITING

Outcomes

Primary Outcomes

Prevalence of hypophosphatasia in adult patients in rheumatology

The primary aim of this prospective observational study is to determine the prevalence of hypophosphatasia in adult patients presenting with musculoskeletal symptoms in rheumatology.

Time frame: 36 months

Central Contacts

Valentin S. Schäfer, Univ.-Prof. Dr. med. MUDr.

CONTACT

+49 228 287-17000 rheumatologie@ukbonn.de

Claus-Jürgen Bauer, MD

CONTACT

+49 228 287-17000 rheumatologie@ukbonn.de

Data from ClinicalTrials.gov

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