Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

Inclusion Criteria: * Mean eGFR * Clinical evidence of active kidney disease * Been on supportive care * vaccine requirements * Females must not be pregnant or breastfeeding * Men must agree to use acceptable contraception and not donate sperm * IgAN: confirmed disease by kidney biopsy performed within 60 months prior to screening * C3G/IC-MPGN: confirmed disease by kidney biopsy performed within 18 months prior to screening Exclusion Criteria: * Hereditary or acquired complement deficiency * Kidney transplant or renal replacement therapy * History of solid organ transplant * Other kidney disease * History of recurrent invasive infections * Received complement inhibitor treatments * Active systemic viral, bacterial, or fungal infection * Liver dysfunction * No donating blood