Safety, Tolerability and Efficacy of Trichostatin A in Patients With Mild to Severe Onychomycosis

Inclusion Criteria: * Willingness to provide signed and dated written voluntary informed consent. * Adults with diagnosis of mild-to-severe DLSO/DSO affecting at least one great toenail. * Positive microscopic examination with KOH for dermatophyte hyphae. * Positive dermatophyte culture or mixed dermatophyte/Candida culture. Exclusion Criteria: * Presence of other toenail infection. * Any disease or condition that may interfere with the evaluation including other conditions that affect the toenails or significant active tinea pedis. * History of other significant chronic fungal disease, psoriasis, lichen planus or use of drug medications for those indications 6 months prior to screening and during the study. * Participation in a previous clinical trial 3 months prior to screening or participation in a research study concurrent with this study. * Current or planned pregnancy during the trial period.