This is a multi-center, randomized, double-blind, double-dummy, placebo/active-controlled study. 200 subjects undergoing abdominal surgery under general anesthesia are planned to be enrolled and randomized into the HSK55718 group, morphine group, and placebo group.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
200
Patients administrated with HSK55718 at dose level 1
Patients administrated with HSK55718 at dose level 2
Patients administrated with HSK55718 at dose level 3
The Third Xiangya Hospital of Central South University
Changsha, Hunan, China
RECRUITINGSichuan Provincial People's Hospital
Chengdu, Sichuan, China
RECRUITINGSum of Pain Intensity Differences (SPID)
Time frame: 24 hours
Sum of Pain Intensity Differences (SPID) in other time frame
Time frame: 0-12 hours, 12-24 hours, 24-48 hours, 48 hours
Number of times rescue analgesic medications were administered.
Time frame: 48 hours
Time to Pain Relief
Time frame: 0-48 hours
Postoperative Analgesia Satisfaction Score
Time frame: 48 hours
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Patients administrated with placebo
Patients administrated with morphine