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Results for “Acute Myeloid Leukemia With NPM1 Mutation”

29 trials

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Showing 20 of 29 results

Large-scale testing (Phase 3)Study completedNCT01237808
What this trial is testing

Study of Low-Dose Cytarabine and Etoposide With or Without All-Trans Retinoic Acid in Older Patients Not Eligible for Intensive Chemotherapy With Acute Myeloid Leukemia and NPM1 Mutation

Who this might be right for
Acute Myeloid Leukemia (AML)
University of Ulm 144
Large-scale testing (Phase 3)Looking for participantsNCT07007312
What this trial is testing

Studies to Assess Ziftomenib in Combination With Ven+Aza or 7+3 in Patients With Untreated NPM1-m or KMT2A-r AML

Who this might be right for
Acute Myeloid Leukemia (AML)
Kura Oncology, Inc. 1,300
Early research (Phase 1)Looking for participantsNCT06575296
What this trial is testing

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

Who this might be right for
Acute LeukemiaAcute Leukemia of Ambiguous LineageAcute Lymphoblastic Leukemia+5 more
City of Hope Medical Center 27
Early research (Phase 1)Looking for participantsNCT06001788
What this trial is testing

Safety and Tolerability of Ziftomenib Combinations in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Who this might be right for
AMLAML With Mutated NPM1Hematologic Malignancy+9 more
Kura Oncology, Inc. 171
Not applicableUnknownNCT04931992
What this trial is testing

Outcome of Patients With CBF and/or NPM1-mutated AML in First Molecular Relapse.

Who this might be right for
Acute Myeloid Leukemia
University Hospital, Angers 100
Testing effectiveness (Phase 2)UnknownNCT04689815
What this trial is testing

Oral Arsenic Trioxide for NPM1-mutated AML

Who this might be right for
NPMc+ AML
The University of Hong Kong 50
Testing effectiveness (Phase 2)Looking for participantsNCT04065399
What this trial is testing

Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaMixed Lineage Acute Leukemia+2 more
Syndax Pharmaceuticals 447
Testing effectiveness (Phase 2)Active Not RecruitingNCT06268574
What this trial is testing

Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML

Who this might be right for
Acute Myeloid Leukemia (AML)High-risk Myelodysplastic Syndrome
Ryvu Therapeutics SA 94
Not applicableAvailableNCT05738538
What this trial is testing

Expanded Access to Ziftomenib

Who this might be right for
Acute Lymphoblastic Leukemia, With Appropriate MutationsAcute Myeloid Leukemia, With NPM1 Mutations
Kura Oncology, Inc.
Early research (Phase 1)Looking for participantsNCT05735184
What this trial is testing

Investigate the Safety and Tolerability of Ziftomenib in Combination With Venetoclax/Azacitidine, Venetoclax, 7+3, or 7+3+Quizartinib in Patients With AML

Who this might be right for
Acute Myeloid LeukemiaMixed Lineage Leukemia Gene MutationRefractory AML+7 more
Kura Oncology, Inc. 420
Testing effectiveness (Phase 2)Looking for participantsNCT05904106
What this trial is testing

Venetoclax Plus Azacitidine Versus Intensive Chemotherapy for Fit Patients With Newly Diagnosed NPM1 Mutated AML

Who this might be right for
Acute Myeloid Leukemia
Technische Universität Dresden 146
Early research (Phase 1)Looking for participantsNCT05886049
What this trial is testing

Testing the Addition of an Anti-cancer Drug, SNDX-5613, to the Standard Chemotherapy Treatment (Daunorubicin and Cytarabine) for Newly Diagnosed Patients With Acute Myeloid Leukemia That Has Changes in NPM1 or MLL/KMT2A Gene

Who this might be right for
Acute Myeloid Leukemia With KMT2A RearrangementAcute Myeloid Leukemia With NPM1 Mutation
National Cancer Institute (NCI) 28
Testing effectiveness (Phase 2)Looking for participantsNCT04988555
What this trial is testing

Enzomenib (DSP-5336) in Patients With Acute Leukemia (Horizen-1)

Who this might be right for
Leukemia, Myeloid, AcuteLeukemia, Lymphocytic, AcuteMultiple Myeloma+1 more
Sumitomo Pharma America, Inc. 606
Testing effectiveness (Phase 2)Active Not RecruitingNCT06052813
What this trial is testing

BN104 in the Treatment of Acute Leukemia

Who this might be right for
ALL, AdultAML, AdultAcute Leukaemia+4 more
Institut de Recherches Internationales Servier (I.R.I.S.) 66
Testing effectiveness (Phase 2)WithdrawnNCT01835288
What this trial is testing

Arsenic Trioxide in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Who this might be right for
Adult Acute Megakaryoblastic Leukemia (M7)Adult Acute Minimally Differentiated Myeloid Leukemia (M0)Adult Acute Monoblastic Leukemia (M5a)+12 more
Stanford University
Early research (Phase 1)Not Yet RecruitingNCT07355335
What this trial is testing

Ziftomenib + Mezigdomide in Adolesc. and Adults w/ R/R AML

Who this might be right for
KMT2A-rearrangedNPM1-mutant Refractory or Relapsed AML
Massachusetts General Hospital 24
Testing effectiveness (Phase 2)Looking for participantsNCT06424340
What this trial is testing

MB-dNPM1-TCR.1 in Relapsed/Refractory AML

Who this might be right for
Leukemia, Myeloid, Acute
Miltenyi Biomedicine GmbH 29
Early research (Phase 1)Ended earlyNCT05153330
What this trial is testing

Study of BMF-219, a Covalent Menin Inhibitor, in Adult Patients With AML, ALL (With KMT2A/ MLL1r, NPM1 Mutations), DLBCL, MM, and CLL/SLL

Who this might be right for
Acute Myeloid LeukemiaAcute Lymphoblastic LeukemiaAcute Mixed-Phenotype Leukemia+12 more
Biomea Fusion Inc. 55
Large-scale testing (Phase 3)Study completedNCT00893399
What this trial is testing

Study of Chemotherapy in Combination With All-trans Retinoic Acid (ATRA) With or Without Gemtuzumab Ozogamicin in Patients With Acute Myeloid Leukemia (AML) and Mutant Nucleophosmin-1 (NPM1) Gene Mutation

Who this might be right for
Acute Myeloid Leukemia
University of Ulm 600
Large-scale testing (Phase 3)Ended earlyNCT05020665
What this trial is testing

Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML

Who this might be right for
Nucleophosmin 1-mutated Acute Myeloid Leukemia
Kronos Bio 15
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