Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Adjunctive Treatment of Major Depressive Disorder (MDD)”

141 trials

Showing 20 of 141 results

Large-scale testing (Phase 3)Study completedNCT02013609
What this trial is testing

Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Active Adults, 18 to 35 Years Old, With Major Depressive Disorder Who Are in a School or Work Environment

Who this might be right for
MDD
Otsuka Pharmaceutical Development & Commercialization, Inc. 48
Large-scale testing (Phase 3)Study completedNCT02013531
What this trial is testing

Brexpiprazole (OPC-34712) as an Adjunctive Treatment in Adults With Major Depressive Disorder and Anxiety Symptoms

Who this might be right for
Major Depressive DisorderAnxiety
Otsuka Pharmaceutical Development & Commercialization, Inc. 37
Large-scale testing (Phase 3)Ended earlyNCT03610048
What this trial is testing

A Long Term Study of ALKS 5461 in the Treatment of Refractory Major Depressive Disorder (MDD)

Who this might be right for
Refractory Major Depressive Disorder
Alkermes, Inc. 175
Not applicableStudy completedNCT02579343
What this trial is testing

Adjunctive Treatment of Major Depression Utilizing Auricular Acupuncture

Who this might be right for
Major Depressive Disorder
Florida Gulf Coast University 13
Post-approval studies (Phase 4)Not Yet RecruitingNCT07369115
What this trial is testing

Neurocircuitry Mechanisms and Efficacy of Lumateperone as Adjunctive Therapy for Major Depressive Disorder and History of Early Life Abuse

Who this might be right for
Major Depressive DiorderEarly Life Trauma
University of Texas at Austin 50
Post-approval studies (Phase 4)Study completedNCT01670019
What this trial is testing

Antidepressant Plus Asenapine Versus Antidepressant Plus Placebo for Depression

Who this might be right for
Major Depressive Disorder Without Psychotic Features
Duke University 46
Large-scale testing (Phase 3)Ended earlyNCT00868374
What this trial is testing

Quetiapine Extended Release (XR) Treatment of Major Depressive Disorder With Comorbid Generalized Anxiety Disorder

Who this might be right for
Major Depressive DisorderGeneralized Anxiety Disorder
Keming Gao 23
Post-approval studies (Phase 4)Study completedNCT04830215
What this trial is testing

Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder

Who this might be right for
Major Depressive Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc. 122
Large-scale testing (Phase 3)Study completedNCT03968159
What this trial is testing

Adjunctive Pimavanserin in Subjects With Major Depressive Disorder and Inadequate Response to Antidepressant Treatment

Who this might be right for
Adjunctive Treatment of Major Depressive Disorder
ACADIA Pharmaceuticals Inc. 298
Not applicableStudy completedNCT01971203
What this trial is testing

Efficacy of Extended-release Quetiapine (Seroquel XR) as Adjunctive Therapy to Cognitive Behavioral Therapy in the Treat

Who this might be right for
Major Depressive DisorderGeneralized Anxiety Disorder
Icahn School of Medicine at Mount Sinai 62
Not applicableStudy completedNCT00953745
What this trial is testing

Dopaminergic Effects of Adjunctive Aripiprazole on the Brain in Treatment-Resistant Depression

Who this might be right for
Major Depressive Disorder
Washington University School of Medicine 43
Large-scale testing (Phase 3)Study completedNCT01838876
What this trial is testing

Long-term Safety and Tolerability of Cariprazine as an Adjunctive Treatment to Antidepressant Therapy in Patients With Major Depressive Disorder

Who this might be right for
Major Depressive Disorder
Forest Laboratories 442
Testing effectiveness (Phase 2)Study completedNCT04969510
What this trial is testing

A Clinical Trial of Adjunctive and Monotherapy PRAX-114 in Participants With Major Depressive Disorder

Who this might be right for
Major Depressive Disorder
Praxis Precision Medicines 110
Testing effectiveness (Phase 2)Study completedNCT01437657
What this trial is testing

MARIGOLD Study: A Study of RO4917523 Versus Placebo as Adjunctive Therapy in Patients With Major Depressive Disorder and an Inadequate Response to Ongoing Antidepressant Therapy

Who this might be right for
Major Depressive Disorder
Hoffmann-La Roche 319
Large-scale testing (Phase 3)Ended earlyNCT06011577
What this trial is testing

Randomized, Double-Blind, Placebo-Controlled Trial of REL-1017 as Adjunctive Treatment for MDD

Who this might be right for
Major Depressive DisorderDepression
Levomecor Inc. 27
Large-scale testing (Phase 3)Study completedNCT02085135
What this trial is testing

Different Titration Schedules of ALKS 5461 in Adults With Major Depressive Disorder (MDD)

Who this might be right for
Major Depressive Disorder
Alkermes, Inc. 66
Testing effectiveness (Phase 2)Study completedNCT01457677
What this trial is testing

ARTDeCo Study: A Study of RO4995819 in Patients With Major Depressive Disorder And Inadequate Response to Ongoing Antidepressant Treatment

Who this might be right for
Major Depressive Disorder
Hoffmann-La Roche 357
Large-scale testing (Phase 3)Study completedNCT03538691
What this trial is testing

A Trial to Evaluate the Efficacy, Safety & Tolerability of Brexpiprazole in the Maintenance Treatment of Adults With Major Depressive Disorder

Who this might be right for
Major Depressive Disorder
Otsuka Pharmaceutical Development & Commercialization, Inc. 1,149
Large-scale testing (Phase 3)Study completedNCT05061719
What this trial is testing

An Open-label Study of Lumateperone as Adjunctive Therapy in the Treatment of Patients With Major Depressive Disorder

Who this might be right for
Major Depressive Disorder
Intra-Cellular Therapies, Inc. 812
Not applicableStudy completedNCT02176408
What this trial is testing

Efficacy of Adjunctive Exercise for the Behavioral Treatment of Major Depression

Who this might be right for
Major Depressive Disorder
Boston University Charles River Campus 38
Next Page

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation