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Results for “Advanced Malignancies and Hepatic Impairment”

31 trials

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Showing 20 of 31 results

Early research (Phase 1)Study completedNCT00621725
What this trial is testing

Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours

Who this might be right for
Advanced CancerHepatic Impairment
AstraZeneca 36
Early research (Phase 1)Study completedNCT00139620
What this trial is testing

A Pharmacokinetic Study of Erlotinib in Cancer Patients With Advanced Solid Tumors, With Adequate and Moderately Impaired Hepatic Function

Who this might be right for
Advanced Solid Tumors
OSI Pharmaceuticals 39
Early research (Phase 1)Looking for participantsNCT07422610
What this trial is testing

Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment

Who this might be right for
Advanced Malignancies and Hepatic Impairment
Novartis Pharmaceuticals 24
Early research (Phase 1)Not Yet RecruitingNCT06823245
What this trial is testing

Pharmacokinetic Study of HS-10241 Tablets in Subjects with Hepatic Impairment and Normal Hepatic Function

Who this might be right for
Advanced Non-small Cell Lung Cancer
Jiangsu Hansoh Pharmaceutical Co., Ltd. 32
Early research (Phase 1)Study completedNCT02997176
What this trial is testing

An Open-Label Pharmacokinetics and Safety Study of Talazoparib (MDV3800)

Who this might be right for
Advanced Solid Tumors
Pfizer 38
Early research (Phase 1)Ended earlyNCT01278849
What this trial is testing

An Open-label, Dose Escalation Study to Assess the Pharmacokinetics of of ASA404 in Adult Cancer Patients With Impaired Hepatic Function

Who this might be right for
Histologically-proven and Radiologically-confirmed Solid Tumors
Novartis Pharmaceuticals 5
Early research (Phase 1)UnknownNCT05101265
What this trial is testing

Clinical Pharmacokinetic Study of Lurbinectedin in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Impairment

Who this might be right for
Advanced Solid TumorHepatic Impairment
PharmaMar 24
Early research (Phase 1)WithdrawnNCT05828277
What this trial is testing

Assess the Effect of Hepatic Impairment on the Pharmacokinetics of Repotrectinib in Advanced Cancer Patients

Who this might be right for
Locally Advanced Solid TumorMetastatic Solid Tumor
Turning Point Therapeutics, Inc.
Early research (Phase 1)Study completedNCT02161770
What this trial is testing

Study to Assess the Blood Levels and Safety of AZD9291 in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Who this might be right for
Solid Tumours
AstraZeneca 30
Early research (Phase 1)Study completedNCT00275093
What this trial is testing

Temsirolimus in Treating Patients With Metastatic Solid Tumor or Lymphoma That Cannot Be Removed By Surgery Who Have Different Levels of Liver Function

Who this might be right for
Hepatic ComplicationsLymphomaUnspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI) 130
Early research (Phase 1)Study completedNCT00437424
What this trial is testing

Brivanib (BMS-582664) in Patients With Liver Cancer and Mild, Moderate or Severe Liver Dysfunction

Who this might be right for
Carcinoma, Hepatocellular
Bristol-Myers Squibb 24
Early research (Phase 1)Study completedNCT04831944
What this trial is testing

To Evaluate the Safety, and Pharmacokinetics of Parscaclisib in Participants With Normal Hepatic Function and Hepatic Impairment.

Who this might be right for
Advanced Malignancies
Incyte Corporation 21
Early research (Phase 1)Study completedNCT02696642
What this trial is testing

Phase I Study of Anetumab Ravtansine in Hepatic or Renal Impairment

Who this might be right for
Neoplasms
Bayer 54
Early research (Phase 1)Ended earlyNCT04241835
What this trial is testing

Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Moderate/Severe Liver Impairment to Participants With Advanced Cancer and Normal Liver Function

Who this might be right for
Hepatic ImpairmentAdvanced Malignant Solid Tumor
Epizyme, Inc. 18
Early research (Phase 1)Study completedNCT03814005
What this trial is testing

Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute+3 more
Takeda 17
Early research (Phase 1)Study completedNCT02150733
What this trial is testing

Pharmacokinetics of Tivantinib in Subjects With Advanced Solid Tumors and Hepatic Impairment

Who this might be right for
Hepatic ImpairmentSolid TumorCancer
Daiichi Sankyo 29
Early research (Phase 1)Not Yet RecruitingNCT05048368
What this trial is testing

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

Who this might be right for
Esophageal CancerAdvanced Solid Tumor
Sunshine Lake Pharma Co., Ltd. 32
Early research (Phase 1)Study completedNCT01894243
What this trial is testing

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Who this might be right for
Solid Tumours
AstraZeneca 31
Early research (Phase 1)Study completedNCT03359850
What this trial is testing

Pharmacokinetic and Safety Study of Niraparib With Normal or Moderate Hepatic Impairment Patients

Who this might be right for
Ovarian NeoplasmsNeoplasmsSolid Tumor+1 more
Tesaro, Inc. 17
Early research (Phase 1)Looking for participantsNCT04617522
What this trial is testing

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

Who this might be right for
Advanced or Metastatic Solid TumorLiver Failure
Gilead Sciences 30
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