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Results for “Advanced Malignancies and Hepatic Impairment”

31 trials

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Showing 20 of 31 results

Early research (Phase 1)Study completedNCT00621725
What this trial is testing

Phase 1 PK Study of Cediranib in Single and Multiple Doses in Hepatically Impaired Patients With Solid Tumours

Who this might be right for
Advanced CancerHepatic Impairment
AstraZeneca 36
Early research (Phase 1)Not Yet RecruitingNCT06823258
What this trial is testing

Pharmacokinetic Study of HS-10365 Capsule in Subjects with Hepatic Impairment and Normal Hepatic Function

Who this might be right for
NSCLC (advanced Non-small Cell Lung Cancer)
Jiangsu Hansoh Pharmaceutical Co., Ltd. 32
Early research (Phase 1)Looking for participantsNCT04617522
What this trial is testing

Study of Sacituzumab Govitecan in Participants With Advanced or Metastatic Solid Tumor and Moderate Liver Impairment

Who this might be right for
Advanced or Metastatic Solid TumorLiver Failure
Gilead Sciences 30
Early research (Phase 1)Study completedNCT03814005
What this trial is testing

Pevonedistat in People With Blood Cancers or Solid Tumors With Kidney or Liver Problems

Who this might be right for
Myelodysplastic SyndromesLeukemia, Myelomonocytic, ChronicLeukemia, Myeloid, Acute+3 more
Takeda 17
Early research (Phase 1)Not Yet RecruitingNCT05048368
What this trial is testing

Pharmacokinetics Study of Larotinib in Subjects With Impaired Hepatic Function

Who this might be right for
Esophageal CancerAdvanced Solid Tumor
Sunshine Lake Pharma Co., Ltd. 32
Testing effectiveness (Phase 2)Looking for participantsNCT06682988
What this trial is testing

Assess Adverse Events and Change in Disease Activity in Participants With Platinum-Resistant Advanced High-Grade Epithelial Ovarian, Primary Peritoneal, or Fallopian Tube Cancers With High Folate Receptor-Alpha Expression Treated With Intravenously (IV) Infused Mirvetuximab Soravtansine

Who this might be right for
Advanced High-Grade Epithelial OvarianPrimary PeritonealFallopian Tube Cancers+2 more
AbbVie 110
Early research (Phase 1)Looking for participantsNCT07036133
What this trial is testing

Study to Evaluate the Pharmacokinetics and Safety of Pralatrexate in Patients With Advanced Solid Tumor or Hematological Malignancy and Either Normal Hepatic Function or Mild, Moderate, or Severe Hepatic Impairment

Who this might be right for
Advanced Solid TumorsHematologic Malignancies
Acrotech Biopharma Inc. 24
Early research (Phase 1)Study completedNCT00437424
What this trial is testing

Brivanib (BMS-582664) in Patients With Liver Cancer and Mild, Moderate or Severe Liver Dysfunction

Who this might be right for
Carcinoma, Hepatocellular
Bristol-Myers Squibb 24
Early research (Phase 1)Study completedNCT03521037
What this trial is testing

Rucaparib Hepatic Impairment Study in Patients With a Solid Tumor

Who this might be right for
Neoplasms
pharmaand GmbH 16
Early research (Phase 1)Study completedNCT02301104
What this trial is testing

A Phase I Study of TAS-102 in Patients With Advanced Solid Tumors With Hepatic Impairment

Who this might be right for
Advanced Solid Tumors
Taiho Oncology, Inc. 24
Early research (Phase 1)Ended earlyNCT03726333
What this trial is testing

Hepatic Impairment Study for Lorlatinib in Cancer Patients

Who this might be right for
Advanced Cancers
Pfizer 1
Early research (Phase 1)Study completedNCT00999882
What this trial is testing

Safety, Tolerability, Pharmacokinetics (PK) and Preliminary Efficacy of Tor Kinase Inhibitor in Liver Cancer Patients

Who this might be right for
CancerAdvanced Hepatocellular Carcinoma
AstraZeneca 26
Early research (Phase 1)Study completedNCT01894243
What this trial is testing

Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal Liver Function or Mild or Moderate Liver Impairment

Who this might be right for
Solid Tumours
AstraZeneca 31
Early research (Phase 1)Study completedNCT00139620
What this trial is testing

A Pharmacokinetic Study of Erlotinib in Cancer Patients With Advanced Solid Tumors, With Adequate and Moderately Impaired Hepatic Function

Who this might be right for
Advanced Solid Tumors
OSI Pharmaceuticals 39
Early research (Phase 1)UnknownNCT05101265
What this trial is testing

Clinical Pharmacokinetic Study of Lurbinectedin in Patients With Advanced Solid Tumors and Varying Degrees of Hepatic Impairment

Who this might be right for
Advanced Solid TumorHepatic Impairment
PharmaMar 24
Early research (Phase 1)Study completedNCT01140607
What this trial is testing

Safety and Pharmacokinetic Study of Cabazitaxel in Patients With Advanced Solid Tumors and Liver Impairment

Who this might be right for
Neoplasm Malignant
Sanofi 56
Early research (Phase 1)Study completedNCT02696642
What this trial is testing

Phase I Study of Anetumab Ravtansine in Hepatic or Renal Impairment

Who this might be right for
Neoplasms
Bayer 54
Early research (Phase 1)Study completedNCT00275093
What this trial is testing

Temsirolimus in Treating Patients With Metastatic Solid Tumor or Lymphoma That Cannot Be Removed By Surgery Who Have Different Levels of Liver Function

Who this might be right for
Hepatic ComplicationsLymphomaUnspecified Adult Solid Tumor, Protocol Specific
National Cancer Institute (NCI) 130
Early research (Phase 1)Study completedNCT01949545
What this trial is testing

Study of the Pharmacokinetics and Safety of Carfilzomib in Patients With Advanced Malignancies and Hepatic Impairment

Who this might be right for
Solid TumorsHematologic MalignanciesHepatic Impairment
Amgen 46
Early research (Phase 1)Not Yet RecruitingNCT07422610
What this trial is testing

Pharmacokinetics and Safety Study of Pelabresib in Patients With Advanced Malignancies and Hepatic Impairment

Who this might be right for
Advanced Malignancies and Hepatic Impairment
Novartis Pharmaceuticals 24
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