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Results for “Advanced PD-L1 Positive Malignancies”

93 trials

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Showing 20 of 93 results

Large-scale testing (Phase 3)Looking for participantsNCT05549297
What this trial is testing

Tebentafusp Regimen Versus Investigator's Choice in Previously Treated Advanced Melanoma (TEBE-AM)

Who this might be right for
Advanced Melanoma
Immunocore Ltd 540
Early research (Phase 1)Ended earlyNCT04795713
What this trial is testing

Study of MT-6402 in Subjects With Advanced Solid Cancer That Expresses PD-L1

Who this might be right for
Advanced Solid TumorNon-small Cell Lung CancerSquamous Cell Carcinoma of Head and Neck
Molecular Templates, Inc. 64
Testing effectiveness (Phase 2)Study completedNCT02031458
What this trial is testing

Atezolizumab in Participants With Programmed Death - Ligand 1 (PD-L1) Positive Locally Advanced or Metastatic Non-Small Cell Lung Cancer

Who this might be right for
Non-Small Cell Lung Cancer
Hoffmann-La Roche 667
Testing effectiveness (Phase 2)Active Not RecruitingNCT05994001
What this trial is testing

Candonilimab in Combination With LM-302 for Claudin 18.2 Positive-advanced Biliary Tract Cancer After Failure of Standard of Chemotherapy and PD1/PD-L1 Antibody

Who this might be right for
Biliary Tract CancerCandonilimabClaudin 18.2
Shanghai Zhongshan Hospital 78
Large-scale testing (Phase 3)Not Yet RecruitingNCT07633873
What this trial is testing

SYS6010 Combined With Enlonstobart Versus Immunotherapy+ Platinum-based Chemotherapy for Patients With PD-L1-Positive Locally Advanced or Metastatic NSCLC(SYNSTAR 04)

Who this might be right for
Non-Small Cell Lung Cancer
CSPC Megalith Biopharmaceutical Co.,Ltd. 500
Testing effectiveness (Phase 2)Active Not RecruitingNCT02849496
What this trial is testing

Testing Olaparib Either Alone or in Combination With Atezolizumab in BRCA Mutant Non-HER2-positive Breast Cancer

Who this might be right for
Anatomic Stage III Breast Cancer AJCC v8Anatomic Stage IV Breast Cancer AJCC v8Locally Advanced Unresectable Breast Carcinoma+1 more
National Cancer Institute (NCI) 89
Not applicableStudy completedNCT05321212
What this trial is testing

Efficacy and Safety of PEMbrolizumab PD-L1-positive (>50% of Tumor Cells), Advanced NSCL Cancer(PEMBREIZH)

Who this might be right for
Carcinoma, Non-Small-Cell LungImmunotherapy
University Hospital, Brest 108
Testing effectiveness (Phase 2)Study completedNCT05535569
What this trial is testing

Phase Ib/II Study to Evaluate the Safety and Efficacy of Nivolumab in Combination With Paclitaxel in Epstein-Barr Virus(EBV)-Related, or Microsatellite Instability-High (MSI-H), or Programmed Cell Death Ligand 1 (PD-L1) Positive Advanced Gastric Cancer

Who this might be right for
Recurrent/Metastatic Gastric Cancer
Yonsei University 50
Large-scale testing (Phase 3)Not Yet RecruitingNCT07818070
What this trial is testing

A Trial of ONO-4578 Versus Placebo in Combination With Nivolumab and Chemotherapy in Participants With Gastric Cancer, Esophagogastric Junction Cancer, or Esophageal Adenocarcinoma

Who this might be right for
Gastric CancerEsophagogastric Junction CancerEsophageal Adenocarcinoma
Ono Pharmaceutical Co., Ltd. 600
Large-scale testing (Phase 3)Looking for participantsNCT05754853
What this trial is testing

MRG002 Versus Investigator's Choice of Chemotherapy in the Treatment of Patients With HER2-positive Unresectable Advanced or Metastatic Urothelial Cancer

Who this might be right for
Advanced or Metastatic Urothelium Cancer
Shanghai Miracogen Inc. 290
Not applicableLooking for participantsNCT07696832
What this trial is testing

Efficacy and Safety of Ivonescimab Monotherapy as First-Line Treatment for PD-L1-Positive, Driver Gene-Negative, Locally Advanced or Metastatic NSCLC: A Multicenter, Prospective, Real-World Cohort Study

Who this might be right for
Patients Must Have Histologically or Cytologically Confirmed Locally Advanced or Metastatic NSCLCEGFR Mutation-negative and ALK Rearrangement-negativeEastern Cooperative Oncology Group Performance Status (ECOG PS) Score of 0 to 2+2 more
Guangdong Association of Clinical Trials
Testing effectiveness (Phase 2)Active Not RecruitingNCT02955290
What this trial is testing

CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or Squamous Head and Neck Cancer

Who this might be right for
Advanced Head and Neck Squamous Cell CarcinomaLung Non-Small Cell CarcinomaMetastatic Lung Non-Small Cell Carcinoma+13 more
Roswell Park Cancer Institute 51
Early research (Phase 1)Ended earlyNCT03455556
What this trial is testing

Anetumab Ravtansine and Atezolizumab in Treating Participants With Advanced Non-small Cell Lung Cancer

Who this might be right for
Mesothelin PositiveStage III Non-Small Cell Lung Cancer AJCC v7Stage IIIA Non-Small Cell Lung Cancer AJCC v7+2 more
Mayo Clinic 1
Large-scale testing (Phase 3)Active Not RecruitingNCT05382286
What this trial is testing

Study of Sacituzumab Govitecan-hziy and Pembrolizumab Versus Treatment of Physician's Choice and Pembrolizumab in Patients With Previously Untreated, Locally Advanced Inoperable or Metastatic Triple-Negative Breast Cancer

Who this might be right for
Triple Negative Breast CancerPD-L1 Positive
Gilead Sciences 443
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07819019
What this trial is testing

A Phase II Study of Irinotecan Liposome Plus Fruquintinib and Sintilimab in Second-Line PD-L1-Positive Advanced Gastric Cancer

Who this might be right for
Stomach NeoplasmsGastric Cancer
Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center 20
Large-scale testing (Phase 3)UnknownNCT04203485
What this trial is testing

Camrelizumab Combined With Apatinib Mesylate or Camrelizumab Alone for First-line Treatment in Subjects With Programmed Death Ligand 1 (PD-L1) Positive Relapsed or Advanced Non-small Cell Lung Cancer (NSCLC)

Who this might be right for
PD-L1 Positive Non-small Cell Lung Cancer
Jiangsu HengRui Medicine Co., Ltd. 762
Testing effectiveness (Phase 2)Active Not RecruitingNCT03620669
What this trial is testing

1st Line Durvalumab in PS 2 NSCLC Patients

Who this might be right for
NSCLC Stage IVNSCLC Stage IIIB
Swiss Cancer Institute 48
Testing effectiveness (Phase 2)Looking for participantsNCT07699939
What this trial is testing

Perioperative HLX10 (Serplulimab) With S-1+Oxaliplatin (SOX) in Locally Advanced and PD-L1-Positive Gastric or Esophagogastric Junction Adenocarcinoma

Who this might be right for
Gastric AdenocarcinomaGastroesophageal Junction (GEJ) Adenocarcinoma
National Cancer Center, Japan 136
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07459738
What this trial is testing

A Phase II Study to Evaluate the Efficacy and Safety of HLX43 in Patients With Hormone Receptor Positive, HER2 Negative Locally Advanced or Metastatic Breast Cancer

Who this might be right for
Hormone Receptor Positive HER-2 Negative Breast Cancer
Shanghai Henlius Biotech 60
Large-scale testing (Phase 3)Ended earlyNCT04740918
What this trial is testing

Trastuzumab Emtansine in Combination With Atezolizumab or Placebo as a Treatment for Participants With Human Epidermal Growth Factor 2 (HER2)-Positive and Programmed Death-ligand 1 (PD-L1)-Positive Locally Advanced (LABC) or Metastatic Breast Cancer (MBC)

Who this might be right for
Metastatic Breast Cancer
Hoffmann-La Roche 96
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