Not applicableLooking for participantsNCT05178277What this trial is testingCzech AATD RegistryWho this might be right forAlpha-1-antitrypsin Deficiency Thomayer University Hospital 300
Not applicableEnded earlyNCT02502201What this trial is testingEnvironment Effect on Six-Minute Walk Test PerformanceWho this might be right forChronic Obstructive Pulmonary DiseaseAlpha-1 Antitrypsin Deficiency University of Florida 27
Early research (Phase 1)Study completedNCT04174118What this trial is testingStudy of DCR-A1AT in Healthy Adult VolunteersWho this might be right forAlpha 1-Antitrypsin Deficiency Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 30
Testing effectiveness (Phase 2)Study completedNCT03008915What this trial is testingTargeting Pulmonary Perfusion in Alpha-1 Antitrypsin DeficiencyWho this might be right forAlpha-1 Antitrypsin DeficiencyEmphysemaChronic Obstructive Pulmonary Disease Columbia University 15
Post-approval studies (Phase 4)Ended earlyNCT00313144What this trial is testingAralast alpha1-proteinase Inhibitor Surveillance StudyWho this might be right forAlpha1-antitrypsin Deficiency Baxalta now part of Shire 127
Not applicableStudy completedNCT01862211What this trial is testingPolygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA CohortWho this might be right forChildren With a Deficiency of Alpha-1 Antitrypsin Hospices Civils de Lyon 296
Testing effectiveness (Phase 2)WithdrawnNCT03385395What this trial is testingStudy Comparing Weekly Intravenous Administration of OctaAlpha1 With a Marketed Preparation Glassia® in Subjects With Alpha-1-antitrypsin DeficiencyWho this might be right forAlpha 1-Antitrypsin Deficiency Octapharma
Testing effectiveness (Phase 2)Study completedNCT00157092What this trial is testingStudy of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin DeficiencyWho this might be right forAlpha1-antitrypsin Deficiency Baxalta now part of Shire 15
Not applicableUnknownNCT04966221What this trial is testingFunctional and Structural Lung Imaging in Chronic Obstructive Pulmonary DiseaseWho this might be right forChronic Obstructive Pulmonary DiseaseAlpha 1-Antitrypsin Deficiency University of Nottingham 75
Testing effectiveness (Phase 2)Study completedNCT02870348What this trial is testingLong-term Safety of Alpha1-Proteinase Inhibitor (Human) in Japanese Subjects With Alpha1 Antitrypsin Deficiency (GTI1401-OLE)Who this might be right forAlpha1-Antitrypsin Deficiency Grifols Therapeutics LLC 4
Not applicableUnknownNCT03455686What this trial is testingExploring the Utility of Hyperpolarized 129Xe MRI in Healthy Volunteers and Patients With Lung DiseaseWho this might be right forAsthmaChronic Obstructive Pulmonary DiseaseBronchiectasis+5 more McMaster University 60
Not applicableUnknownNCT03285100What this trial is testingThe Effects of Discontinuation of Vitamin K Antagonists on the Rate of Elastin DegradationWho this might be right forEmphysema or COPDAneurysmCystic Fibrosis+1 more Canisius-Wilhelmina Hospital 30
Not applicableStudy completedNCT00001885What this trial is testingIdentification of Genes Associated With Lung Disease in Patients With Rheumatoid ArthritisWho this might be right forHealthyPulmonary FibrosisRheumatoid Arthritis National Heart, Lung, and Blood Institute (NHLBI) 400
Large-scale testing (Phase 3)Study completedNCT00301366What this trial is testingThe Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) DeficiencyWho this might be right forAlpha 1-Antitrypsin Deficiency Grifols Therapeutics LLC 38
Not applicableUnknownNCT02929940What this trial is testingLiver Disease in Patients With alpha1-antitrypsin DeficiencyWho this might be right foralpha1-antitrypsin Deficiency RWTH Aachen University 500
Not applicableUnknownNCT03802357What this trial is testingEffects of Different Exercise Training Modalities in Alpha-1 Antitrypsin Deficiency PatientsWho this might be right forChronic Obstructive Pulmonary DiseaseAlpha 1-Antitrypsin Deficiency Schön Klinik Berchtesgadener Land 30
Not applicableLooking for participantsNCT00001532What this trial is testingRole of Genetic Factors in the Development of Lung DiseaseWho this might be right forCystic FibrosisPulmonary FibrosisTuberous Sclerosis+2 more National Heart, Lung, and Blood Institute (NHLBI) 3,500
Early research (Phase 1)Study completedNCT01319331What this trial is testingThe Effects of Alpha-1 Antitrypsin (AAT) on the Progression of Type 1 DiabetesWho this might be right forDiabetesType 1 Diabetes University of Colorado, Denver 12
Large-scale testing (Phase 3)Looking for participantsNCT05677971What this trial is testingStudy to Check the Safety of Fazirsiran and Learn if Fazirsiran Can Help People With Liver Disease and Scarring (Fibrosis) Due to an Abnormal Version of Alpha-1 Antitrypsin ProteinWho this might be right forAlpha1-Antitrypsin Deficiency Takeda 160
Not applicableActive Not RecruitingNCT05297812What this trial is testingAlpha-1 Antitrypsin Disease Cohort: Longitudinal Biomarker Study of DiseaseWho this might be right forAlpha 1-Antitrypsin DeficiencyGenetic Disease Columbia University 286