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Results for “Anticoagulation Reversal”

26 trials

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Showing 20 of 26 results

Testing effectiveness (Phase 2)Study completedNCT02206100
What this trial is testing

PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin

Who this might be right for
Healthy
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 40
Early research (Phase 1)Ended earlyNCT00770718
What this trial is testing

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

Who this might be right for
Intracranial Hemorrhage
University of Utah 2
Not applicableStudy completedNCT04614090
What this trial is testing

Fast Reversal of Warfarin and Early Surgery in Patients With Trochanteric Hip Fracture A Case-control Study

Who this might be right for
Trochanteric Hip FracturesWarfarin MedicationEarly Surgery
Karolinska Institutet 198
Post-approval studies (Phase 4)Study completedNCT03140631
What this trial is testing

Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation

Who this might be right for
Atrial FibrillationCatheter Ablation
University of Michigan 153
Large-scale testing (Phase 3)Study completedNCT02207725
What this trial is testing

A Study in Older Subjects to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Apixaban

Who this might be right for
Bleeding
Portola Pharmaceuticals 68
Early research (Phase 1)Looking for participantsNCT07024160
What this trial is testing

Phase I Study of MT1011 Injection in Healthy Subjects

Who this might be right for
Used in Patients Receiving Anticoagulant Therapy (e.g., Rivaroxaban or Apixaban, Inhibitors of Coagulation Factor Xa) Who Require Reversal of Anticoagulation
Shaanxi Micot Pharmaceutical Technology Co., Ltd. 40
Post-approval studies (Phase 4)Study completedNCT01343381
What this trial is testing

Comparison of Heparin Types; Efficacy and Safety

Who this might be right for
Coronary Artery Disease
McMaster University 21
Large-scale testing (Phase 3)Study completedNCT00803101
What this trial is testing

An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure

Who this might be right for
Reversal of Coagulopathy
CSL Behring 176
Post-approval studies (Phase 4)Study completedNCT03064035
What this trial is testing

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal

Who this might be right for
Acute Bleeding on Long-Term Anticoagulation TherapyHemorrhageSignificant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time)+1 more
HealthPartners Institute 79
Large-scale testing (Phase 3)Study completedNCT02329327
What this trial is testing

A Study in Participants With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

Who this might be right for
Bleeding
Alexion Pharmaceuticals, Inc. 479
Testing effectiveness (Phase 2)Study completedNCT02207257
What this trial is testing

Study of PER977 Administered to Subjects With Steady State Edoxaban Dosing and Re-anticoagulation With Edoxaban

Who this might be right for
Anticoagulation Reversal
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 65
Not applicableLooking for participantsNCT06429787
What this trial is testing

Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

Who this might be right for
Vitamin K-Dependent Coagulation DefectSignificant Bleeding Risk
Octapharma 3,574
Post-approval studies (Phase 4)Study completedNCT01159210
What this trial is testing

Efficacy and Safety of Prothromplex Total (Prothrombin Complex Concentrate) in Oral Anticoagulant Reversal

Who this might be right for
Prothrombin Complex Factor Deficiency
Baxalta now part of Shire 61
Post-approval studies (Phase 4)UnknownNCT03473132
What this trial is testing

Assessment of Coagulation Factor Levels in Left Ventricular Device (LVAD )Patients Following Temporary Warfarin Reversal With Four Factor Prothrombin Complex Concentrate (4F-PCC)

Who this might be right for
AnticoagulationAnticoagulation Reversal
Brigham and Women's Hospital 50
Large-scale testing (Phase 3)Study completedNCT02220725
What this trial is testing

A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban

Who this might be right for
Bleeding
Portola Pharmaceuticals 80
Large-scale testing (Phase 3)Study completedNCT00618098
What this trial is testing

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Who this might be right for
Reversal of Anticoagulant Treatment
Octapharma 200
Not applicableStudy completedNCT01795781
What this trial is testing

Assays for and Reversal of New Anticoagulants

Who this might be right for
Atrial FibrillationOsteoarthritis of the KneeOsteoarthritis of the Hip
R.P.Herrmann 30
Large-scale testing (Phase 3)Study completedNCT00168077
What this trial is testing

Prothrombin Complex Concentrate for Anticoagulant Reversal

Who this might be right for
Acquired Coagulation Factor Deficiency
CSL Behring 40
Testing effectiveness (Phase 2)Study completedNCT02206087
What this trial is testing

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PER977 Following Heparin

Who this might be right for
Healthy
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 60
Early research (Phase 1)Study completedNCT01826266
What this trial is testing

Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban

Who this might be right for
Anticoagulant ReversalReversal of Edoxaban Induced Anticoagulation
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 83
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