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Results for “Anticoagulation Reversal”

26 trials

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Showing 20 of 26 results

Testing effectiveness (Phase 2)WithdrawnNCT04794348
What this trial is testing

Clinical Trial Assessing Non-Inferiority of Freeze Dried Plasma to Fresh Frozen Plasma in Reversing Warfarin

Who this might be right for
Anticoagulant Reversal
Vascular Solutions LLC
Large-scale testing (Phase 3)Study completedNCT02329327
What this trial is testing

A Study in Participants With Acute Major Bleeding to Evaluate the Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Direct and Indirect Oral Anticoagulants (Extension Study)

Who this might be right for
Bleeding
Alexion Pharmaceuticals, Inc. 479
Not applicableUnknownNCT02745054
What this trial is testing

Safety of Oral Anticoagulants Registry

Who this might be right for
Blood Coagulation
Hospital Quality Foundation 1,500
Testing effectiveness (Phase 2)Study completedNCT02206087
What this trial is testing

Evaluation of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamic Effects of PER977 Following Heparin

Who this might be right for
Healthy
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 60
Large-scale testing (Phase 3)Study completedNCT00168077
What this trial is testing

Prothrombin Complex Concentrate for Anticoagulant Reversal

Who this might be right for
Acquired Coagulation Factor Deficiency
CSL Behring 40
Testing effectiveness (Phase 2)Study completedNCT02206100
What this trial is testing

PK and PD of Single, Escalating Doses of PER977 Following Enoxaparin

Who this might be right for
Healthy
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 40
Post-approval studies (Phase 4)Study completedNCT03140631
What this trial is testing

Use of Protamine for Heparin Reversal After Catheter Ablation of Atrial Fibrillation

Who this might be right for
Atrial FibrillationCatheter Ablation
University of Michigan 153
Large-scale testing (Phase 3)Study completedNCT02740335
What this trial is testing

Study of Octaplex, a Four-factor Prothrombin Complex Concentrate (4F-PCC) and Beriplex® P/N (Kcentra) for the Reversal of Vitamin K Antagonist (VKA) Induced Anticoagulation in Patients Needing Urgent Surgery With Significant Bleeding Risk.

Who this might be right for
Significant Bleeding Risk
Octapharma 208
Early research (Phase 1)Ended earlyNCT00770718
What this trial is testing

Factor VII, Prothrombin Complex Concentrate, and Fresh Frozen Plasma in Warfarin-Related Intracranial Hemorrhage

Who this might be right for
Intracranial Hemorrhage
University of Utah 2
Post-approval studies (Phase 4)Study completedNCT03064035
What this trial is testing

Fixed Versus Variable Dosing of 4-factor Prothrombin Complex Concentrate for Emergent Warfarin Reversal

Who this might be right for
Acute Bleeding on Long-Term Anticoagulation TherapyHemorrhageSignificant Bleeding in Patients With a Coagulopathy (Prolonged Thrombin Time)+1 more
HealthPartners Institute 79
Large-scale testing (Phase 3)Study completedNCT02220725
What this trial is testing

A Study in Older Subject to Evaluate the Safety and Ability of Andexanet Alfa to Reverse the Anticoagulation Effect of Rivaroxaban

Who this might be right for
Bleeding
Portola Pharmaceuticals 80
Early research (Phase 1)Study completedNCT01826266
What this trial is testing

Effects of a Double-Blind, Single Dose of PER977 Administered Alone, and Following a Single Dose of Edoxaban

Who this might be right for
Anticoagulant ReversalReversal of Edoxaban Induced Anticoagulation
Perosphere Pharmaceuticals Inc, a wholly owned subsidiary of AMAG Pharmaceuticals, Inc. 83
Large-scale testing (Phase 3)Study completedNCT00708435
What this trial is testing

Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared With Plasma in Patients With Acute Major Bleeding Caused by Anticoagulant Therapy

Who this might be right for
Blood Coagulation DisordersAcute Major Bleeding
CSL Behring 216
Large-scale testing (Phase 3)Study completedNCT00618098
What this trial is testing

Study of Octaplex (Human Prothrombin Complex Concentrate) and Fresh Frozen Plasma in Patients Under Vitamin K Therapy Antagonist Needing Urgent Surgery or Invasive Procedures

Who this might be right for
Reversal of Anticoagulant Treatment
Octapharma 200
Testing effectiveness (Phase 2)Ended earlyNCT04593784
What this trial is testing

Study of Ciraparantag for Reversal of Anticoagulation Induced by Edoxaban, Apixaban or Rivaroxaban in Healthy Adults

Who this might be right for
Healthy
AMAG Pharmaceuticals, Inc. 41
Early research (Phase 1)Looking for participantsNCT07024160
What this trial is testing

Phase I Study of MT1011 Injection in Healthy Subjects

Who this might be right for
Used in Patients Receiving Anticoagulant Therapy (e.g., Rivaroxaban or Apixaban, Inhibitors of Coagulation Factor Xa) Who Require Reversal of Anticoagulation
Shaanxi Micot Pharmaceutical Technology Co., Ltd. 40
Large-scale testing (Phase 3)Study completedNCT00803101
What this trial is testing

An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared With Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure

Who this might be right for
Reversal of Coagulopathy
CSL Behring 176
Large-scale testing (Phase 3)Looking for participantsNCT05156983
What this trial is testing

TAK-330 to Reverse the Effects of Factor Xa Inhibitors For Adults Needing Urgent Surgery

Who this might be right for
Coagulation Disorder
Takeda 328
Not applicableLooking for participantsNCT06429787
What this trial is testing

Post Marketing Observational Study on Safety of BALFAXAR vs. KCENTRA for Reversal of Vitamin K Antagonist Induced Anticoagulation in Adults Undergoing Urgent Surgery or Invasive Procedure

Who this might be right for
Vitamin K-Dependent Coagulation DefectSignificant Bleeding Risk
Octapharma 3,574
Not applicableStudy completedNCT01795781
What this trial is testing

Assays for and Reversal of New Anticoagulants

Who this might be right for
Atrial FibrillationOsteoarthritis of the KneeOsteoarthritis of the Hip
R.P.Herrmann 30
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