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Results for “Autosomal Dominant”

595 trials

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Showing 20 of 595 results

Large-scale testing (Phase 3)Looking for participantsNCT06989112
What this trial is testing

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Who this might be right for
Endometrial Cancer
AstraZeneca 600
Not applicableStudy completedNCT06155045
What this trial is testing

Comparing a New Technique of Combining Carbon-dioxide With Electrocautery With Usual Technique of Stand-alone Electrocautery for Taking Down Left Internal Mammary Artery for Coronary Artery Bypass(CABG)

Who this might be right for
Coronary Artery DiseaseCoronary Artery Disease With Myocardial Infarction
Government Medical College Kottayam 46
Early research (Phase 1)Study completedNCT02054806
What this trial is testing

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-028/KEYNOTE-28)

Who this might be right for
Solid Tumor
Merck Sharp & Dohme LLC 477
Testing effectiveness (Phase 2)Study completedNCT03631407
What this trial is testing

Safety and Efficacy of Vicriviroc (MK-7690) in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic Microsatellite Stable (MSS) Colorectal Cancer (CRC) (MK-7690-046)

Who this might be right for
Colorectal Neoplasms
Merck Sharp & Dohme LLC 41
Early research (Phase 1)Study completedNCT07074327
What this trial is testing

Effects of VX-407 on the Pharmacokinetics of Oral Contraceptives in Healthy Participants

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
Vertex Pharmaceuticals Incorporated 74
Large-scale testing (Phase 3)Active Not RecruitingNCT04246177
What this trial is testing

Safety and Efficacy of Lenvatinib (E7080/MK-7902) With Pembrolizumab (MK-3475) in Combination With Transarterial Chemoembolization (TACE) in Participants With Incurable/Non-metastatic Hepatocellular Carcinoma (MK-7902-012/E7080-G000-318/LEAP-012)

Who this might be right for
Carcinoma, Hepatocellular
Merck Sharp & Dohme LLC 480
Large-scale testing (Phase 3)Ended earlyNCT06424236
What this trial is testing

Dominantly Inherited Alzheimer Network Trial: An Opportunity to Prevent Dementia: A Study of Potential Disease Modifying Treatments in Individuals at Risk for or With a Type of Early Onset Alzheimer's Disease Caused by a Genetic Mutation

Who this might be right for
Alzheimers DiseaseDementiaAlzheimers Disease, Familial
Washington University School of Medicine 73
Testing effectiveness (Phase 2)Study completedNCT05149898
What this trial is testing

Open-Label Study of ZYN002 Administered as a Transdermal Gel to Children and Adolescents With 22q11.2 Deletion Syndrome (INSPIRE)

Who this might be right for
22Q11.2 Deletion Syndrome
Harmony Biosciences Management, Inc. 20
Early research (Phase 1)Study completedNCT04208152
What this trial is testing

A First-in-Human Study of Single and Multiple Doses of anle138b in Healthy Subjects

Who this might be right for
Healthy Volunteers
MODAG GmbH 68
Not applicableLooking for participantsNCT06618638
What this trial is testing

Shared Decision Making for Choosing Autosomal DOminant Polycystic Kidney Disease Treatment

Who this might be right for
ADPKD (autosomal Dominant Polycystic Kidney Disease)
Seoul National University Hospital 340
Not applicableStudy completedNCT03493802
What this trial is testing

Assessment of Longitudinal Changes in Endothelial Function and Oxidative Stress in Normotensive Patients With ADPKD

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease
Mayo Clinic 18
Not applicableEnrolling By InvitationNCT03901521
What this trial is testing

Autosomal Dominant Polycystic Kidney Disease Somatic Mutation Biorepository

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease
Weill Medical College of Cornell University 100
Large-scale testing (Phase 3)Active Not RecruitingNCT03711032
What this trial is testing

Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Bacillus Calmette-Guerin (BCG) in High-Risk Non-Muscle Invasive Bladder Cancer (HR NMIBC) (MK-3475-676/KEYNOTE-676)

Who this might be right for
High-risk Non-muscle Invasive Bladder Cancer
Merck Sharp & Dohme LLC 1,397
Not applicableUnknownNCT04004832
What this trial is testing

Comparison of the Severity of Coronary Atherosclerosis With Tissue Compliance in Patients Within First Degree Relatives

Who this might be right for
Coronary Artery Disease With Myocardial Infarction
TC Erciyes University 60
Not applicableUnknownNCT04886193
What this trial is testing

FLOT Combined With PD-1 in the First-line Treatment of Patients With Advanced Gastric Cancer and Peritoneal Metastasis

Who this might be right for
ChemotherapyGastric Cancer
Guangdong Provincial Hospital of Traditional Chinese Medicine 20
Large-scale testing (Phase 3)Active Not RecruitingNCT03553836
What this trial is testing

Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)

Who this might be right for
Melanoma
Merck Sharp & Dohme LLC 976
Large-scale testing (Phase 3)Study completedNCT01866319
What this trial is testing

Study to Evaluate the Safety and Efficacy of Two Different Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Participants With Advanced Melanoma (MK-3475-006/KEYNOTE-006)

Who this might be right for
Melanoma
Merck Sharp & Dohme LLC 834
Testing effectiveness (Phase 2)Study completedNCT00500812
What this trial is testing

A Safety Study for Cethrin (BA-210) in the Treatment of Acute Thoracic and Cervical Spinal Cord Injuries

Who this might be right for
Spinal Cord Injury
Vertex Pharmaceuticals Incorporated 48
Not applicableUnknownNCT03917537
What this trial is testing

WGA in Platinum-refractory HNSCC Underwent Nivolumab

Who this might be right for
HNSCC
Chang Gung Memorial Hospital 80
Large-scale testing (Phase 3)Active Not RecruitingNCT04662710
What this trial is testing

Efficacy and Safety of Lenvatinib (E7080/MK-7902) Plus Pembrolizumab (MK-3475) Plus Chemotherapy in Participants With Advanced/Metastatic Gastroesophageal Adenocarcinoma (MK-7902-015/E7080-G000-321/LEAP-015)

Who this might be right for
Advanced/Metastatic Gastroesophageal Adenocarcinoma
Merck Sharp & Dohme LLC 895
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