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Results for “Autosomal Dominant”

610 trials

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Showing 20 of 610 results

Testing effectiveness (Phase 2)UnknownNCT05178836
What this trial is testing

A Phase II Study to Evaluate the Efficacy and Safety of F520 Combined With F007 in Patients With RR DLBCL

Who this might be right for
RR DLBCL; PD-1; CD20
Shandong New Time Pharmaceutical Co., LTD 62
Large-scale testing (Phase 3)Study completedNCT00465985
What this trial is testing

Efficacy, Safety, and Tolerability of ACZ885 in Patients With Muckle-Wells Syndrome

Who this might be right for
Muckle Wells Syndrome
Novartis 35
Not applicableUnknownNCT06257225
What this trial is testing

Evaluation of Horizontal Bone Gain in the Lower Posterior Partially Edentulous Patient Comparing the Stabilization of Membranes With and Without Tacs

Who this might be right for
Guided Bone Regeneration
Cairo University 22
Not applicableLooking for participantsNCT06967831
What this trial is testing

Drug Repurposing for Mitochondrial Disorders Using iPSCs Derived Neural Cells

Who this might be right for
Leigh Syndrome (Maternally Inherited, MILS)Leigh Syndrome (AR, AD, XR)
Charite University, Berlin, Germany 80
Not applicableActive Not RecruitingNCT06496542
What this trial is testing

Renal Oxygen Consumption, Insulin Sensitivity, and Daily Caloric Restriction in ADPKD

Who this might be right for
Autosomal Dominant Polycystic Kidney
University of Colorado, Denver 14
Testing effectiveness (Phase 2)Active Not RecruitingNCT06483334
What this trial is testing

Efficacy and Safety of Sacituzumab Tirumotecan (MK-2870) Plus Enfortumab Vedotin (EV) With and Without Pembrolizumab in Advanced Urothelial Carcinoma (MK-3475-04C/KEYMAKER-U04)

Who this might be right for
Metastatic Urothelial CarcinomaLocally Advanced Urothelial Carcinoma
Merck Sharp & Dohme LLC 38
Large-scale testing (Phase 3)Active Not RecruitingNCT03553836
What this trial is testing

Safety and Efficacy of Pembrolizumab Compared to Placebo in Resected High-risk Stage II Melanoma (MK-3475-716/KEYNOTE-716)

Who this might be right for
Melanoma
Merck Sharp & Dohme LLC 976
Early research (Phase 1)Study completedNCT05017012
What this trial is testing

Evaluate the Bioavailability of Pembrolizumab (MK-3475) Via Subcutaneous (SC) Injection of Pembrolizumab Formulated With Berahyaluronidase Alfa (MK-5180) [MK-3475A] In Advanced Solid Tumors (MK-3475A-C18)

Who this might be right for
Advanced or Metastatic Solid Tumors
Merck Sharp & Dohme LLC 142
Large-scale testing (Phase 3)Study completedNCT01866319
What this trial is testing

Study to Evaluate the Safety and Efficacy of Two Different Dosing Schedules of Pembrolizumab (MK-3475) Compared to Ipilimumab in Participants With Advanced Melanoma (MK-3475-006/KEYNOTE-006)

Who this might be right for
Melanoma
Merck Sharp & Dohme LLC 834
Large-scale testing (Phase 3)Study completedNCT03142334
What this trial is testing

Safety and Efficacy Study of Pembrolizumab (MK-3475) as Monotherapy in the Adjuvant Treatment of Renal Cell Carcinoma Post Nephrectomy (MK-3475-564/KEYNOTE-564)

Who this might be right for
Renal Cell Carcinoma
Merck Sharp & Dohme LLC 994
Testing effectiveness (Phase 2)Active Not RecruitingNCT06305767
What this trial is testing

A Clinical Study of Intismeran Autogene (V940) Treatment and Pembrolizumab in People With Bladder Cancer (V940-005/INTerpath-005)

Who this might be right for
Bladder Cancer
Merck Sharp & Dohme LLC 230
Testing effectiveness (Phase 2)Active Not RecruitingNCT05608044
What this trial is testing

Botensilimab and Balstilimab for the Treatment of Colorectal Cancer

Who this might be right for
Metastatic Colorectal Cancer
Agenus Inc. 234
Not applicableUnknownNCT02848521
What this trial is testing

A Study Measuring Quality of Life, Treatment Preference and Satisfaction of ADPKD Patients in Europe

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease
Otsuka Pharmaceutical Europe Ltd 407
Early research (Phase 1)Looking for participantsNCT06714006
What this trial is testing

Phase 1 Study to Evaluate the Safety and Tolerability of Intravenously Administered PYC-003

Who this might be right for
Autosomal Dominant Polycystic Kidney Disease (ADPKD)
PYC Therapeutics 166
Not applicableUnknownNCT05500157
What this trial is testing

Assessment of Treatment With Laparoscopic Fenestration or Aspiration Sclerotherapy for Large Symptomatic Hepatic Cysts

Who this might be right for
Liver CystPolycystic Liver DiseaseAutosomal Dominant Polycystic Kidney+1 more
Radboud University Medical Center 70
Not applicableUnknownNCT03726463
What this trial is testing

Evaluation of Iliac and Renal Artery for Mechanism of Intracranial Aneurysm in ADPKD

Who this might be right for
Kidney Transplant; ComplicationsPolycystic Kidney DiseasesAneurysm, Brain
Asan Medical Center 100
Large-scale testing (Phase 3)Study completedNCT03834506
What this trial is testing

Study of Pembrolizumab (MK-3475) Plus Docetaxel Versus Placebo Plus Docetaxel in Chemotherapy-naïve Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-3475-921/KEYNOTE-921)

Who this might be right for
Prostatic Neoplasms
Merck Sharp & Dohme LLC 1,030
Not applicableLooking for participantsNCT04111692
What this trial is testing

A Prospective Observational Study of Foam Sclerotherapy .

Who this might be right for
Autosomal Dominant Polycystic KidneyRenal CystAutosomal Dominant Polycystic Liver Disease+1 more
Mayo Clinic 100
Early research (Phase 1)Ended earlyNCT04135352
What this trial is testing

Intratumoral/Intralesional Administration of V938 in Combination With Pembrolizumab (MK-3475) in Participants With Advanced/Metastatic or Recurrent Malignancies (V938-001)

Who this might be right for
Neoplasm Metastasis
Merck Sharp & Dohme LLC 35
Large-scale testing (Phase 3)Study completedNCT03066778
What this trial is testing

Pembrolizumab (MK-3475) in Combination With Etoposide/Platinum (Cisplatin or Carboplatin) for Participants With Extensive Stage Small Cell Lung Cancer (MK-3475-604/KEYNOTE-604)

Who this might be right for
Small Cell Lung Cancer (SCLC)
Merck Sharp & Dohme LLC 453
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