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Results for “BTKi”

47 trials

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Showing 20 of 47 results

Early research (Phase 1)Study completedNCT05024045
What this trial is testing

Study of Oral LOXO-338 in Patients With Advanced Blood Cancers

Who this might be right for
Leukemia, Lymphocytic, Chronic, B-CellLymphoma, B-cell Marginal ZoneLymphoma, Non-Hodgkin+4 more
Eli Lilly and Company 27
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07819214
What this trial is testing

Epcoritamab as Consolidation Therapy for High-Risk Pts w/CLL on BTKI

Who this might be right for
CLLCLL (Chronic Lymphocytic Leukemia)Chronic Lymphocytic Leukemia (CLL)+1 more
University of California, Irvine 24
Testing effectiveness (Phase 2)Active Not RecruitingNCT06524375
What this trial is testing

Evaluate the Effect of Venetoclax on Participants Receiving a Covalent Bruton's Tyrosine Kinase Inhibitor (cBTKi) for First-line Chronic Lymphocytic Leukemia (1L CLL) to Achieve Deep Durable Remissions to Allow Off-treatment Period

Who this might be right for
Chronic Lymphocytic Leukemia
Genentech, Inc. 118
Testing effectiveness (Phase 2)Study completedNCT02639910
What this trial is testing

Study to Evaluate Safety and Preliminary Efficacy of Tafasitamab With Idelalisib or Venetoclax in R/R CLL/SLL Patients Pretreated With BTKi

Who this might be right for
Leukemia, Lymphocytic, Chronic, B-CellChronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
MorphoSys AG 24
Testing effectiveness (Phase 2)Looking for participantsNCT07108998
What this trial is testing

Study of Epcoritamab as a Consolidation Therapy in CLL/SLL

Who this might be right for
CLL/SLLCLLSLL+4 more
Zulfa Omer 22
Testing effectiveness (Phase 2)Looking for participantsNCT06985472
What this trial is testing

Orelabrutinib Combined With Zuberitamab in the Initial Treatment of MZL

Who this might be right for
Initial MZLUntreated MZLBTKi+1 more
Li Zhiming 33
Testing effectiveness (Phase 2)Looking for participantsNCT06558604
What this trial is testing

Phase II Study of Glofitamab With Venetoclax +/- Zanubrutinib in High-risk Mantle-cell Lymphoma

Who this might be right for
Lymphoma, Mantle-Cell
The Lymphoma Academic Research Organisation 100
Not applicableNot Yet RecruitingNCT07711327
What this trial is testing

Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy

Who this might be right for
Atrial Fibrillation (AF)Chronic Lymphocytic LeukemiaWaldenstrom Macroglobulinemia+2 more
Tina Baykaner 500
Post-approval studies (Phase 4)Looking for participantsNCT07218341
What this trial is testing

Pirtobrutinib (LY3527727) in Participants With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Who this might be right for
Chronic Lymphocytic LeukemiaLymphoma, Small Lymphocytic
Eli Lilly and Company 150
Large-scale testing (Phase 3)Active Not RecruitingNCT05707377
What this trial is testing

Examine the Efficacy and Safety of Zanubrutinib Given to Adults With Primary Membranous Nephropathy

Who this might be right for
Primary Membranous Nephropathy
BeOne Medicines 178
Not applicableActive Not RecruitingNCT04882475
What this trial is testing

Biological Insights of First Relapsed-refractory Patients With Mantle Cell Lymphoma: the MANTLE-FIRST BIO Study.

Who this might be right for
Mantle Cell Lymphoma
Fondazione Italiana Linfomi - ETS 160
Not applicableLooking for participantsNCT07120633
What this trial is testing

Anti CD19 CAR-T Combined With BTKi to Treat Newly Diagnosed High-risk CLL/SLL

Who this might be right for
CLLCAR-T Cell TherapySLL
The Affiliated Hospital of Xuzhou Medical University 50
Large-scale testing (Phase 3)Looking for participantsNCT05254743
What this trial is testing

Pirtobrutinib (LOXO-305) Versus Ibrutinib in Participants With Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL)

Who this might be right for
Chronic Lymphocytic LeukemiaLeukemia, LymphocyticLeukemia, B-cell+1 more
Loxo Oncology, Inc. 737
Testing effectiveness (Phase 2)Looking for participantsNCT06504940
What this trial is testing

Optimize Study - Orelabrutinib Combined With BR/G in Untreated Marginal Zone Lymphoma (MZL)

Who this might be right for
Marginal Zone Lymphoma
First Affiliated Hospital of Zhejiang University 69
Testing effectiveness (Phase 2)Active Not RecruitingNCT05249959
What this trial is testing

Consolidation With Loncastuximab Tesirine After a Short Course of Immunochemotherapy in BTKi-treated (or Intolerant) Relapsed/Refractory Mantle Cell Lymphoma Patients.

Who this might be right for
Relapsed Mantle Cell LymphomaRefractory Mantle Cell Lymphoma
Fondazione Italiana Linfomi - ETS 49
Early research (Phase 1)Not Yet RecruitingNCT07574073
What this trial is testing

CD20 Monoclonal Antibody Combined With BTK Inhibitor for the Treatment of Refractory Immune-related Cytopenia

Who this might be right for
Anti-CD20 Monoclonal AntibodyBTK InhibitorsImmune Thrombocytopenia (ITP)+1 more
Qi deng 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06476899
What this trial is testing

A Practical Clinical Study Comparing the Fixed-cycle Regimen Containing Orelabrutinib With BTKi Monotherapy

Who this might be right for
CLL/SLL
Fei Li 60
Testing effectiveness (Phase 2)Looking for participantsNCT07257055
What this trial is testing

Phase 2 Study of BTKi-Rituximab Induction Followed by Glofitamab Consolidation in High Risk Untreated MCL Patients - WINDOW-4 Study

Who this might be right for
Phase 2 StudyMCLBTKi+2 more
M.D. Anderson Cancer Center 30
Large-scale testing (Phase 3)WithdrawnNCT06205290
What this trial is testing

Compare the Efficacy and Safety of Lisocabtagene Maraleucel vs Investigator's Choice Options in Adult Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma, Whose Disease Has Failed Treatment With Both BTKi and BCL2i Therapies

Who this might be right for
Leukemia, Lymphocytic, Chronic, B-Cell
Juno Therapeutics, Inc., a Bristol-Myers Squibb Company
Large-scale testing (Phase 3)Active Not RecruitingNCT04965493
What this trial is testing

A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL)

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Loxo Oncology, Inc. 600
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