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Results for “Bruton's Tyrosine Kinase”

188 trials

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Showing 20 of 188 results

Testing effectiveness (Phase 2)UnknownNCT04742400
What this trial is testing

Tolebrutinib, a Brain-penetrant Bruton's Tyrosine Kinase Inhibitor, for the Modulation of Chronically Inflamed White Matter Lesions in Multiple Sclerosis

Who this might be right for
Multiple Sclerosis
National Institute of Neurological Disorders and Stroke (NINDS) 12
Large-scale testing (Phase 3)Study completedNCT04458051
What this trial is testing

Primary Progressive Multiple Sclerosis (PPMS) Study of Bruton's Tyrosine Kinase (BTK) Inhibitor Tolebrutinib (SAR442168) (PERSEUS)

Who this might be right for
Primary Progressive Multiple Sclerosis
Sanofi 767
Testing effectiveness (Phase 2)Study completedNCT05068440
What this trial is testing

Treatment of CD79B Mutant Relapsed/Refractory Diffuse Large B-Cell Lymphoma With Bruton Tyrosine Kinase Inhibitor Zanubrutinib

Who this might be right for
Relapsed Diffuse Large B-cell LymphomaRefractory Diffuse Large B-cell Lymphoma
BeiGene 65
Large-scale testing (Phase 3)Study completedNCT01776840
What this trial is testing

The Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma

Who this might be right for
Mantle Cell Lymphoma
Janssen Research & Development, LLC 523
Testing effectiveness (Phase 2)Active Not RecruitingNCT03162536
What this trial is testing

Nemtabrutinib (MK-1026) in Participants With Relapsed or Refractory Hematologic Malignancies (ARQ 531-101/MK-1026-001)

Who this might be right for
Lymphoma, B-CellSmall Lymphocytic LymphomaChronic Lymphocytic Leukemia+6 more
ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 190
Large-scale testing (Phase 3)WithdrawnNCT02735876
What this trial is testing

Acalabrutinib in Combination With Rituximab Versus Ibrutinib Versus Acalabrutinib in Subjects With Relapsed or Refractory Mantle Cell Lymphoma

Who this might be right for
Mantle Cell Lymphoma
Acerta Pharma BV
Early research (Phase 1)Study completedNCT05190068
What this trial is testing

HMPL-760 in Relapsed/Refractory B-Cell Non-Hodgkin's Lymphoma

Who this might be right for
B-Cell Non-Hodgkin's Lymphoma
Hutchmed 89
Testing effectiveness (Phase 2)Study completedNCT02362035
What this trial is testing

ACP-196 (Acalabrutinib) in Combination With Pembrolizumab, for Treatment of Hematologic Malignancies

Who this might be right for
Follicular Lymphoma (FL)CLLSmall Lymphocytic Lymphoma (SLL)+10 more
Acerta Pharma BV 161
Testing effectiveness (Phase 2)Looking for participantsNCT06588478
What this trial is testing

A Study Evaluating the Efficacy and Safety of Pirtobrutinib in Participants With Relapsed or Refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma

Who this might be right for
Chronic Lymphocytic LeukemiaSmall Lymphocytic Lymphoma
Loxo Oncology, Inc. 249
Testing effectiveness (Phase 2)Looking for participantsNCT06812715
What this trial is testing

Clonal Dynamics of Chronic Lymphocytic Leukaemia Treated With Pirtobrutinib After Previous Treatment With Zanubrutinib

Who this might be right for
Chronic Lymphocytic Leukemia
Peter MacCallum Cancer Centre, Australia 40
Large-scale testing (Phase 3)Looking for participantsNCT07104032
What this trial is testing

IGNITE: Study of Tirabrutinib vs Rituximab/Temozolomide for Relapsed/Refractory Primary Central Nervous System Lymphoma (PCNSL)

Who this might be right for
Relapsed/Refractory Primary Central Nervous System Lymphoma
Ono Pharmaceutical Co., Ltd. 132
Large-scale testing (Phase 3)Study completedNCT05032157
What this trial is testing

Efficacy and Safety of Remibrutinib in the Treatment of CSU in Adults Inadequately Controlled by H1-antihistamines

Who this might be right for
Chronic Spontaneous Urticaria
Novartis Pharmaceuticals 455
Testing effectiveness (Phase 2)Study completedNCT03685708
What this trial is testing

HEPLISAV-B Hepatitis B Vaccine in Chronic Lymphocytic Leukemia (CLL) and CLL Treated With Bruton's-Tyrosine Kinase Inhibitor (BTK-I)

Who this might be right for
HepatitisSafety and Tolerability
National Heart, Lung, and Blood Institute (NHLBI) 78
Early research (Phase 1)Study completedNCT03198650
What this trial is testing

Acalabrutinib in Japanese Adult Patients With Advanced B-cell Malignancies

Who this might be right for
Part1: Advanced B-cell MalignanciesPart2: r/rCLL and r/rMCLPart3: Untreated CLL
AstraZeneca 35
Early research (Phase 1)Ended earlyNCT03400176
What this trial is testing

VAY736 in Combination With Ibrutinib in Patients With CLL on Ibrutinib

Who this might be right for
Chronic Lymphocytic Leukemia (CLL)
Novartis Pharmaceuticals 39
Not applicableNot Yet RecruitingNCT07711327
What this trial is testing

Atrial Fibrillation Among Patients With Hematologic Malignancies on Tyrosine Kinase Inhibitor Therapy

Who this might be right for
Atrial Fibrillation (AF)Chronic Lymphocytic LeukemiaWaldenstrom Macroglobulinemia+2 more
Tina Baykaner 500
Testing effectiveness (Phase 2)Study completedNCT03233230
What this trial is testing

Phase IIb Study of Evobrutinib in Subjects With Rheumatoid Arthritis

Who this might be right for
Rheumatoid Arthritis
EMD Serono Research & Development Institute, Inc. 390
Early research (Phase 1)Study completedNCT04768985
What this trial is testing

Study to Assess the Bioequivalence of Acalabrutinib Tablet and Acalabrutinib Capsule

Who this might be right for
Bioequivalence
AstraZeneca 66
Testing effectiveness (Phase 2)Active Not RecruitingNCT04234061
What this trial is testing

Clinical Trial to Assess The Efficacy and Safety of the Combination of Tisagenlecleucel And Ibrutinib in Mantle Cell Lymphoma

Who this might be right for
Mantle Cell Lymphoma Recurrent
Peter MacCallum Cancer Centre, Australia 20
Testing effectiveness (Phase 2)UnknownNCT05020288
What this trial is testing

A Clinical Trial of the Orelabrutinib in the Management of Refractory ITP

Who this might be right for
Immune ThrombocytopeniaBruton's Tyrosine Kinase
Shandong University 40
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