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Results for “C9orf72 Amyotrophic Lateral Sclerosis (ALS)”

18 trials

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Showing 18 of 18 results

Not applicableStudy completedNCT01925196
What this trial is testing

Natural History and Biomarkers of Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Caused by the C9ORF72 Gene Mutation

Who this might be right for
Amyotrophic Lateral SclerosisFrontotemporal Lobar Degeneration
National Institute of Neurological Disorders and Stroke (NINDS) 50
Early research (Phase 1)Ended earlyNCT04288856
What this trial is testing

Study to Assess the Safety, Tolerability, Pharmacokinetics, and Effect on Disease Progression of BIIB078 Administered to Previously Treated Adults C9ORF72-Associated Amyotrophic Lateral Sclerosis (ALS)

Who this might be right for
Amyotrophic Lateral Sclerosis
Biogen 75
Testing effectiveness (Phase 2)Study completedNCT04993755
What this trial is testing

A Phase 2a Study of TPN-101 in Patients With C9ORF72 ALS/FTD

Who this might be right for
Amyotrophic Lateral SclerosisFrontotemporal Dementia
Transposon Therapeutics, Inc. 42
Testing effectiveness (Phase 2)Ended earlyNCT05683860
What this trial is testing

Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)

Who this might be right for
Amyotrophic Lateral SclerosisFrontotemporal Dementia
Wave Life Sciences USA, Inc. 8
Testing effectiveness (Phase 2)Ended earlyNCT04931862
What this trial is testing

Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) or Frontotemporal Dementia (FTD)

Who this might be right for
ALSFTD
Wave Life Sciences USA, Inc. 35
Not applicableLooking for participantsNCT07302321
What this trial is testing

Needs of ALS Patients With C9orf72 Mutation and Their Caregivers

Who this might be right for
Amyotrophic Lateral Sclerosis
Istituto Auxologico Italiano 208
Not applicableStudy completedNCT05852405
What this trial is testing

Clinical Characteristics, Natural History, Health Care Measures, and Genetic Screening in Patients With ALS

Who this might be right for
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Ambulanzpartner Soziotechnologie APST GmbH 2,000
Testing effectiveness (Phase 2)Study completedNCT05189106
What this trial is testing

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial

Who this might be right for
Amyotrophic Lateral SclerosisAlzheimer DiseaseMild Cognitive Impairment
Massachusetts General Hospital 17
Testing effectiveness (Phase 2)Active Not RecruitingNCT04220021
What this trial is testing

Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD

Who this might be right for
C9orf72 Amyotrophic Lateral Sclerosis (ALS)Frontotemporal Dementia
University of Florida 41
Not applicableLooking for participantsNCT03865420
What this trial is testing

Amyotrophic Lateral Sclerosis (ALS) Families Project

Who this might be right for
ALS
Columbia University 300
Testing effectiveness (Phase 2)Ended earlyNCT05053035
What this trial is testing

Evaluate AL001 in C9orf72-Associated ALS

Who this might be right for
Amyotrophic Lateral Sclerosis
Alector Inc. 5
Not applicableLooking for participantsNCT04363684
What this trial is testing

ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration (ALLFTD)

Who this might be right for
Frontotemporal Lobar Degeneration (FTLD)Progressive Supranuclear Palsy (PSP)Corticobasal Degeneration (CBD)+11 more
Mayo Clinic 2,100
Not applicableStudy completedNCT04819555
What this trial is testing

Frequency of SOD1 and C9orf72 Gene Mutations in French ALS

Who this might be right for
Amyotrophic Lateral Sclerosis
University Hospital, Tours 1,000
Not applicableStudy completedNCT02686268
What this trial is testing

Understanding Clinical Phenotype and Collecting Biomarker Samples in C9ORF72 ALS

Who this might be right for
C9ORF72 Amyotrophic Lateral Sclerosis (ALS)
Washington University School of Medicine 128
Testing effectiveness (Phase 2)Study completedNCT05163886
What this trial is testing

Study of Safety, Tolerability, and Biological Activity of LAM-002A in C9ORF72-Associated Amyotrophic Lateral Sclerosis

Who this might be right for
Amyotrophic Lateral SclerosisALS
OrphAI Therapeutics 14
Early research (Phase 1)Study completedNCT03626012
What this trial is testing

Assess the Safety, Tolerability, and Pharmacokinetics of BIIB078 in Adults With C9ORF72-Associated Amyotrophic Lateral Sclerosis

Who this might be right for
Amyotrophic Lateral Sclerosis
Biogen 106
Not applicableLooking for participantsNCT00317616
What this trial is testing

The Pre-symptomatic Familial Amyotrophic Lateral Sclerosis (Pre-fALS) Study

Who this might be right for
Amyotrophic Lateral Sclerosis
University of Miami 500
Early research (Phase 1)Active Not RecruitingNCT07204977
What this trial is testing

Acamprosate in C9orf72 Hexanucleotide Repeat Expansion Amyotrophic Lateral Sclerosis (ACALS)

Who this might be right for
Amyotrophic Lateral SclerosisMotor Neuron Disease
National Institute of Neurological Disorders and Stroke (NINDS) 30