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Results for “CDKN2A”

52 trials

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Showing 20 of 52 results

Early research (Phase 1)Active Not RecruitingNCT04794699
What this trial is testing

Study of IDE397 in Participants With Solid Tumors Harboring MTAP Deletion

Who this might be right for
Solid Tumor
IDEAYA Biosciences 169
Early research (Phase 1)Study completedNCT06267963
What this trial is testing

Understand What the Body Does to the Study Medicine Called PF-07220060 When Taken by Healthy Adults

Who this might be right for
Healthy Participants
Pfizer 12
Early research (Phase 1)Looking for participantsNCT06120283
What this trial is testing

BGB-43395 Alone or as Part of Combination Therapies in Participants With Breast Cancer and Other Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorAdvanced Breast CancerMetastatic Breast Cancer+6 more
BeOne Medicines 399
Testing effectiveness (Phase 2)UnknownNCT02202200
What this trial is testing

Phase I-II Study With Tumor Molecular Pharmacodynamic (MPD) Evaluation and Pharmacokinetics of PD-0332991 in Patients Suffering Metastatic Melanoma

Who this might be right for
Melanoma BRAF V600E/K MutatedCDNKN2A Loss Defined
Assistance Publique - Hôpitaux de Paris 40
Testing effectiveness (Phase 2)Ended earlyNCT02688907
What this trial is testing

Phase II, Single-arm Study of AZD1775 Monotherapy in Relapsed Small Cell Lung Cancer Patients With MYC Family Amplification or CDKN2A Mutation Combined With TP53 Mutation

Who this might be right for
Small Cell Lung Cancer
Samsung Medical Center 7
Early research (Phase 1)Looking for participantsNCT06257264
What this trial is testing

Examine the Safety of Different Doses of BG-68501 Given to Participants With Advanced-Stage Tumors

Who this might be right for
Breast CancerSmall Cell Lung CancerOvarian Cancer+9 more
BeiGene 258
Testing effectiveness (Phase 2)WithdrawnNCT06090318
What this trial is testing

Milademetan in Combination With Atezolizumab in Patients With Advanced Solid Tumors With CDKN2A Loss

Who this might be right for
Advanced Solid TumorCDKN2ANSCLC+7 more
Rain Oncology Inc
Early research (Phase 1)Looking for participantsNCT05216432
What this trial is testing

First-in-Human Study of Mutant-selective PI3Kα Inhibitor, RLY-2608, as a Single Agent in Patients With Advanced Solid Tumors and in Combination With Endocrine Therapy +/- a CDK4/6 or CDK4 Inhibitor in Patients With Advanced Solid Tumors or Advanced Breast Cancer

Who this might be right for
PIK3CA MutationSolid Tumor, AdultHER2-negative Breast Cancer+4 more
Relay Therapeutics, Inc. 930
Not applicableUnknownNCT00343213
What this trial is testing

Diagnostic and Prognostic Value of p16INK4a Expression in Low Grade Squamous Intraepithelial Lesions of the Cervix.

Who this might be right for
Cervical Intraepithelial Neoplasia Grade 1 (CIN 1)
University Hospital, Strasbourg, France 300
Early research (Phase 1)Ended earlyNCT02620839
What this trial is testing

Phase Ib Study of Alpelisib With Cisplatin in Patients With HPV+ Solid Tumor Malignancies

Who this might be right for
Solid Tumors
Pamela Munster 28
Early research (Phase 1)Active Not RecruitingNCT06253195
What this trial is testing

BGB-43395 Alone or as Part of Combination Therapies in Chinese Participants With HR+/HER2- Breast Cancer and Other Advanced Solid Tumors

Who this might be right for
Advanced Solid TumorMetastatic Solid TumorHormone-receptor-positive Breast Cancer+4 more
BeiGene 33
Large-scale testing (Phase 3)Looking for participantsNCT04966481
What this trial is testing

Palbociclib and Cetuximab Versus Cetuximab Monotherapy for Patients With CDKN2A-altered, HPV-unrelated Head and Neck Squamous Cell Carcinoma Who Experienced Disease Progression on a PD-1/L1 Inhibitor

Who this might be right for
HPV-unrelated Head and Neck Squamous Cell Carcinoma
Washington University School of Medicine 81
Early research (Phase 1)Study completedNCT05923411
What this trial is testing

Multiple Tablet Forms of The Study Medicine (PF-07220060) in Healthy Adults

Who this might be right for
Healthy Participants
Pfizer 113
Testing effectiveness (Phase 2)Looking for participantsNCT02734537
What this trial is testing

Radiation Therapy With or Without Cisplatin in Treating Patients With Stage III-IVA Squamous Cell Carcinoma of the Head and Neck Who Have Undergone Surgery

Who this might be right for
Head and Neck Squamous Cell CarcinomaHypopharyngeal Squamous Cell CarcinomaLaryngeal Squamous Cell Carcinoma+13 more
ECOG-ACRIN Cancer Research Group 189
Not applicableLooking for participantsNCT06789653
What this trial is testing

A Novel Approach Utilizing Organ Specific Age Proteomics

Who this might be right for
Breast Cancer
UNC Lineberger Comprehensive Cancer Center 60
Large-scale testing (Phase 3)Not Yet RecruitingNCT07492641
What this trial is testing

BGB-43395 Plus Letrozole Versus CDK4/6i Plus Letrozole for Patients With Advanced or Metastatic HR+/HER2- Breast Cancer Who Have Not Received Prior Treatment for Advanced or Metastatic Disease

Who this might be right for
HR+/HER2- Breast Cancer
BeOne Medicines 1,056
Testing effectiveness (Phase 2)Ended earlyNCT05935748
What this trial is testing

Ph2 Study NKT2152 With Palbociclib & Sasanlimab in Subjects With Advanced Clear Cell Renal Cell Carcinoma (ccRcc)

Who this might be right for
ccRCCClear Cell Renal Cell CarcinomaKidney Cancer+18 more
NiKang Therapeutics, Inc. 18
Testing effectiveness (Phase 2)Ended earlyNCT02478320
What this trial is testing

Phase II Study of Ilorasertib (ABT348) in Patients With CDKN2A Deficient Solid Tumors

Who this might be right for
Advanced Cancers
M.D. Anderson Cancer Center 12
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06509997
What this trial is testing

A Phase II Study of Anti-EGFR Antibody-drug Conjugate (ADC) Combine With CDK4/6 Inhibitors Posterior Line in the Treatment of Recurrent/Metastatic CDKN2A Gene Variant Head and Neck Squamous Cell Carcinoma

Who this might be right for
Head and Neck Squamous Cell Carcinoma
Lei Liu 30
Very early researchStudy completedNCT02846935
What this trial is testing

P53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Refractory/Relapsed Lymphoid Malignancies

Who this might be right for
T-cell LymphomaAggressive B-cell LymphomaNon-Hodgkin's Lymphomas+1 more
Yogen Saunthararajah 7
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