Testing effectiveness (Phase 2)Study completedNCT01120626What this trial is testingRandomized Controlled Study of Donepezil in Fragile X SyndromeWho this might be right forFragile X Syndrome Stanford University 45
Testing effectiveness (Phase 2)Active Not RecruitingNCT05231798What this trial is testingCholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and CognitionWho this might be right forDown SyndromeDown Syndrome, Partial Trisomy 21Alzheimer Disease Vanderbilt University Medical Center 20
Large-scale testing (Phase 3)Study completedNCT01918033What this trial is testingThe Efficacy and Safety of Desloratadine (MK-4117) in Japanese Participants With Perennial Allergic Rhinitis (MK-4117-200)Who this might be right forPerennial Allergic Rhinitis Organon and Co 608
Not applicableStudy completedNCT03904186What this trial is testingEffectiveness of an Integrated Treatment to Address Smoking Cessation and Anxiety/ Depression in People Living With HIVWho this might be right forHuman Immunodeficiency VirusSmoking CessationSmoking, Cigarette+4 more Massachusetts General Hospital 131
Post-approval studies (Phase 4)Study completedNCT03840837What this trial is testingCholinergic Neurotransmission in Mobility and Cognition in Parkinson DiseaseWho this might be right forParkinson DiseaseParkinson Disease Dementia University of Maryland, Baltimore 31
Testing effectiveness (Phase 2)Study completedNCT02933372What this trial is testingCholinergic Mechanisms of Gait Dysfunction in Parkinson's Disease Experiments 1 & 2 - Proj #3Who this might be right forParkinson's Disease University of Michigan 25
Early research (Phase 1)Study completedNCT03408574What this trial is testingThe Nicotinic Cholinergic System and Cognitive AgingWho this might be right forHealthy Aging University of Vermont 104
Not applicableStudy completedNCT03090854What this trial is testingCholinergic Markers Alzheimer's DiseaseWho this might be right forAlzheimer Disease Assistance Publique - Hôpitaux de Paris 100
Post-approval studies (Phase 4)Looking for participantsNCT07284290What this trial is testingElucidating the Role of Cholinergic Degeneration in Cognitive Fluctuations in Lewy Body DementiaWho this might be right forDementia With Lewy BodiesParkinson Disease DementiaHealthy Controls Virginia Commonwealth University 120
Not applicableUnknownNCT02952391What this trial is testingAssessing Cholinergic Innervation in Parkinson's Disease Using the PET Imaging Marker [18F]FluoroethoxybenzovesamicolWho this might be right forParkinson's Disease University Medical Center Groningen 20
Testing effectiveness (Phase 2)Looking for participantsNCT06865651What this trial is testingStudy of Remibrutinib (LOU064) Efficacy and Safety and Exploration of Its Mechanism of Action in Participants With Chronic UrticariaWho this might be right forChronic Urticaria (CU): Chronic Inducible Urticaria (CINDU) and Chronic Spontaneous Urticaria (CSU) Novartis Pharmaceuticals 44
Post-approval studies (Phase 4)UnknownNCT00912457What this trial is testingDonepezil Treatment for Sleep Apnea PatientsWho this might be right forObstructive Sleep Apnea Associacao Fundo de Incentivo a Psicofarmcologia 60
Testing effectiveness (Phase 2)Study completedNCT03384784What this trial is testingEffect of Galantamine on Inflammation and CognitionWho this might be right forHIV Associated Cognitive Motor Complex University of Pennsylvania 63
Testing effectiveness (Phase 2)Study completedNCT02206620What this trial is testingEffects of Cholinergic Augmentation on Measures of Balance and GaitWho this might be right forParkinson's Disease Oregon Health and Science University 49
Testing effectiveness (Phase 2)Ended earlyNCT05710640What this trial is testingTranscutaneous Cervical Vagus Nerve Stimulation (tcVNS) in JIAWho this might be right forJuvenile Idiopathic Arthritis (JIA) National Institute of Allergy and Infectious Diseases (NIAID) 18
Large-scale testing (Phase 3)UnknownNCT02098824What this trial is testingSymptomatic Treatment of Vascular Cognitive ImpairmentWho this might be right forMild Cognitive Impairment (Vascular)Mild Cognitive Disorder (Vascular)Vascular Dementia Amsterdam UMC, location VUmc 30
Not applicableStudy completedNCT02689466What this trial is testingCholinergic Receptor Imaging in DystoniaWho this might be right forCervical DystoniaDystoniaMovement Disorder+1 more National Institute of Neurological Disorders and Stroke (NINDS) 31
Not applicableStudy completedNCT04875949What this trial is testingAnti-Cholinergic Receptors Antibodies, Autonomic Profile and Dysautonomia Symptoms in PAF, ALS and POTS (DISAUT-AB)Who this might be right forPure Autonomic FailureAmyotrophic Lateral SclerosisPostural Orthostatic Tachycardia Syndrome+1 more Istituto Clinico Humanitas 75
Not applicableStudy completedNCT02071693What this trial is testingA Retrospective Study of the Relationship Between White Matter Hyperintensities(WMHs) Within the Cholinergic Pathways and the Cognition of PD Patients After Bilateral STN DBSWho this might be right forParkinson's Disease First Affiliated Hospital, Sun Yat-Sen University 38
Not applicableEnded earlyNCT02154009What this trial is testingClinical Autonomic Disorders: A Training ProtocolWho this might be right forPosttraumatic Stress DisorderPseudopheochromocytomaHealthy Volunteers+2 more National Institute of Neurological Disorders and Stroke (NINDS) 21