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Results for “Complement Activity”

24 trials

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Showing 20 of 24 results

Testing effectiveness (Phase 2)Study completedNCT00000421
What this trial is testing

Serologically Active, Clinically Stable Systemic Lupus Erythematosus

Who this might be right for
Systemic Lupus Erythematosus
NYU Langone Health 154
Large-scale testing (Phase 3)Active Not RecruitingNCT04434092
What this trial is testing

A Study Evaluating the Efficacy and Safety of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Not Previously Treated With Complement Inhibitors

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 210
Large-scale testing (Phase 3)Study completedNCT06799546
What this trial is testing

A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
PNH
Haisco Pharmaceutical Group Co., Ltd. 73
Large-scale testing (Phase 3)Study completedNCT02994927
What this trial is testing

Clinical Trial of CCX168 (Avacopan) in Patients With ANCA-Associated Vasculitis

Who this might be right for
ANCA-Associated Vasculitis
Amgen 331
Testing effectiveness (Phase 2)Study completedNCT05695248
What this trial is testing

Navenibart (STAR-0215) in Participants With Hereditary Angioedema

Who this might be right for
Hereditary Angioedema
Astria Therapeutics, Inc. 29
Testing effectiveness (Phase 2)Study completedNCT03439839
What this trial is testing

Study of Safety, Efficacy, Tolerability, Pharmacokinetics and Pharmacodynamics of LNP023 in in Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH) With Signs of Active Hemolysis
Novartis Pharmaceuticals 16
Testing effectiveness (Phase 2)UnknownNCT05033925
What this trial is testing

Ficus Septica Leaves Fraction as a Complementary Therapy for Stadium IV Breast Cancer Patients

Who this might be right for
Breast Cancer Stage IV
Gadjah Mada University 324
Large-scale testing (Phase 3)Study completedNCT06593938
What this trial is testing

Evaluate the Efficacy and Safety of Oral HRS-5965 in Adult Paroxysmal Nocturnal Hemoglobinuria (PNH) Patients Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Chengdu Suncadia Medicine Co., Ltd. 76
Not applicableStudy completedNCT01858792
What this trial is testing

A Pooled Analysis of the HGS1006-C1056 (BLISS-52) and HGS1006-C1057 (BLISS-76) Studies

Who this might be right for
Lupus Erythematosus, Discoid
Human Genome Sciences Inc., a GSK Company 1
Testing effectiveness (Phase 2)Study completedNCT03896152
What this trial is testing

Efficacy, Safety, Pharmacokinetics and Pharmacodynamics Study, Assessing Multiple LNP023 Doses in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 13
Large-scale testing (Phase 3)Active Not RecruitingNCT04432584
What this trial is testing

A Study Evaluating the Safety, Pharmacokinetics, and Efficacy of Crovalimab Versus Eculizumab in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Complement Inhibitors

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Hoffmann-La Roche 190
Early research (Phase 1)Study completedNCT04723602
What this trial is testing

Evaluation of Safety, Tolerability and Immune Responses of Ebola-S and Marburg Vaccines in Healthy Adults

Who this might be right for
Ebola Virus DiseaseMarburg Virus Disease
Albert B. Sabin Vaccine Institute 32
Early research (Phase 1)Study completedNCT05988034
What this trial is testing

Assess the Effect of Avacopan at Therapeutic and Supratherapeutic Doses on the QT/QTc Interval in Healthy Participants

Who this might be right for
Electrocardiography
Amgen 58
Large-scale testing (Phase 3)Study completedNCT02946463
What this trial is testing

ALXN1210 (Ravulizumab) Versus Eculizumab in Complement Inhibitor Treatment-Naïve Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Alexion Pharmaceuticals, Inc. 272
Testing effectiveness (Phase 2)Ended earlyNCT02464891
What this trial is testing

Complement Inhibition in aHUS Dialysis Patients

Who this might be right for
Atypical Hemolytic Uremic Syndrome
Mario Negri Institute for Pharmacological Research 6
Testing effectiveness (Phase 2)Ended earlyNCT01919346
What this trial is testing

Eculizumab for Prevention of Delayed Graft Function (DGF) in Kidney Transplantation

Who this might be right for
Delayed Graft FunctionKidney TransplantationComplement Activity
Heeger, Peter, M.D. 21
Early research (Phase 1)Study completedNCT02819102
What this trial is testing

An Open-label Drug-Drug Interaction Study to Evaluate the Effect of BCX7353 on Cytochrome P450 Enzyme Activity Using Probe Substrates

Who this might be right for
Hereditary Angioedema
BioCryst Pharmaceuticals 20
Large-scale testing (Phase 3)Not Yet RecruitingNCT07747090
What this trial is testing

The Efficacy and Safety of FXS6837 Capsules Compared to Eculizumab for 24 Weeks in Patients With PNH.

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. 90
Testing effectiveness (Phase 2)Looking for participantsNCT06419205
What this trial is testing

Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G

Who this might be right for
IgA NephropathyLupus Nephritis (LN)C3 (Complement Component 3) Glomerulopathy
Akebia Therapeutics 30
Post-approval studies (Phase 4)Looking for participantsNCT07142343
What this trial is testing

Test the Safety of Pozelimab in Pediatric Participants 1 to 5 Years of Age With a Rare Disease Called CHAPLE (Complement Hyperactivation, Angiopathic Thrombosis, Protein-losing Enteropathy) Disease

Who this might be right for
CHAPLE Disease
Regeneron Pharmaceuticals 5
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