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Results for “Complement Mediated Diseases”

36 trials

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Showing 20 of 36 results

Early research (Phase 1)Study completedNCT03316521
What this trial is testing

First-In-Human Clinical Study of the C3 Complement Inhibitor AMY- 101 in Healthy Male Volunteers

Who this might be right for
Complement Mediated Diseases
Amyndas Pharmaceuticals S.A. 50
Early research (Phase 1)UnknownNCT06558656
What this trial is testing

Effect of Food of NTQ5082 in Healthy Subjects

Who this might be right for
Complement-mediated Hemolytic Diseases
Nanjing Chia-tai Tianqing Pharmaceutical 12
Testing effectiveness (Phase 2)Study completedNCT05083364
What this trial is testing

Study of ARO-C3 in Adult Healthy Volunteers and Patients With Complement Mediated Renal Disease

Who this might be right for
C3 GlomerulopathyIgA Nephropathy
Arrowhead Pharmaceuticals 62
Testing effectiveness (Phase 2)Looking for participantsNCT07522099
What this trial is testing

Chinese Adults With Kidney Disease

Who this might be right for
Immunoglobulin A Nephropathy (IgAN)Complement 3 Glomerulopathy (C3G)IC-MPGN
ADARx Pharmaceuticals, Inc. 30
Early research (Phase 1)Looking for participantsNCT06371417
What this trial is testing

Phase 1b Trial of RAY121 in Immunological Diseases (RAINBOW Trial)

Who this might be right for
Antiphospholipid Syndrome (APS)Bullous Pemphigoid (BP)Behçet's Syndrome (BS)+3 more
Chugai Pharmaceutical 144
Testing effectiveness (Phase 2)Looking for participantsNCT07046806
What this trial is testing

Oral Deucrictibant for Prophylactic and Acute Treatment in Hereditary Angioedema Patients

Who this might be right for
Hereditary Angioedema (HAE)AngioedemaBradykinin-mediated Angioedema+1 more
Institute for Asthma and Allergy 10
Not applicableWithdrawnNCT05304091
What this trial is testing

Characterization of Rhythmicity Profiles of Bradykinin-mediated Angioedema Attacks Using a Tracking Smartphone Application.

Who this might be right for
Bradykinin-mediated Angioedema
University Hospital, Lille
Early research (Phase 1)Study completedNCT06674915
What this trial is testing

Investigation of Pharmacokinetics,Safety,and Pharmacodynamics of HRS-5965 in Subjects With Hepatic Impairment

Who this might be right for
Complement Mediated Primary or Secondary Glomerular Diseases
Chengdu Suncadia Medicine Co., Ltd. 24
Large-scale testing (Phase 3)Study completedNCT02013037
What this trial is testing

The De-novo Use of Eculizumab in Presensitized Patients Receiving Cardiac Transplantation

Who this might be right for
Antibody-mediated RejectionHyperacute Rejection of Cardiac TransplantLeft Ventricular Dysfunction+2 more
Cedars-Sinai Medical Center 36
Early research (Phase 1)Looking for participantsNCT05318534
What this trial is testing

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

Who this might be right for
First in Man Study to Evaluate Initial Safety
Gliknik Inc. 70
Testing effectiveness (Phase 2)Ended earlyNCT03459443
What this trial is testing

A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471

Who this might be right for
C3 GlomerulonephritisC3 GlomerulopathyImmune Complex Membranoproliferative Glomerulonephritis+2 more
Alexion Pharmaceuticals, Inc. 22
Early research (Phase 1)Study completedNCT07040787
What this trial is testing

Investigation of Drug-drug Interaction of HRS-5965 With Clopidogrel and Clarithromycin in Healthy Subjects

Who this might be right for
Complement Mediated Glomerular DiseasesHemolytic Anemia
Chengdu Suncadia Medicine Co., Ltd. 36
Early research (Phase 1)Study completedNCT06209177
What this trial is testing

Study of ARO-CFB in Adult Healthy Volunteers

Who this might be right for
IgA Nephropathy
Arrowhead Pharmaceuticals 49
Early research (Phase 1)Study completedNCT02502903
What this trial is testing

Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders

Who this might be right for
Bullous Pemphigoid (BP)Cold Agglutinin Disease (CAD)Warm Autoimmune Hemolytic Anemia (WAIHA)+1 more
Bioverativ, a Sanofi company 122
Testing effectiveness (Phase 2)Active Not RecruitingNCT06786338
What this trial is testing

SGB-9768 in Patients With Complement-mediated Kidney Diseases

Who this might be right for
IgA Nephropathy (IgAN)C3 GlomerulopathyIC-MPGN
Suzhou Sanegene Bio Inc. 45
Testing effectiveness (Phase 2)Study completedNCT03369236
What this trial is testing

A Proof-of-Concept Study of Danicopan for 6 Months of Treatment in Participants With C3 Glomerulopathy (C3G)

Who this might be right for
C3 GlomerulopathyC3 GlomerulonephritisDense Deposit Disease
Alexion Pharmaceuticals, Inc. 13
Early research (Phase 1)Study completedNCT06567392
What this trial is testing

Evaluate the Mass Balance of [14C] HRS-5965 in Healthy Adult Male Volunteers

Who this might be right for
Complement Mediated Primary or Secondary Glomerular Diseases
Chengdu Suncadia Medicine Co., Ltd. 6
Not applicableEnded earlyNCT05072912
What this trial is testing

Screening Study to Identify Patients With Complement Factor I Deficiencies

Who this might be right for
Previous Diagnosis With a Complement-mediated Disease and/or With Clinical Manifestations Reasonably Associated With Complement Factor I Deficiency
Catalyst Biosciences 113
Testing effectiveness (Phase 2)Active Not RecruitingNCT05121376
What this trial is testing

A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema

Who this might be right for
Hereditary AngioedemaHAE
BioMarin Pharmaceutical 44
Early research (Phase 1)Study completedNCT06797375
What this trial is testing

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RLYB116 in Healthy Participants

Who this might be right for
Hematologic DiseasesAutoimmune Diseases
Rallybio 16
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