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Results for “Complement-mediated Disorders”

36 trials

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Showing 20 of 36 results

Not applicableStudy completedNCT01945307
What this trial is testing

Complement 2: Blood Donations to Develop Vaccines Against Infectious Diseases

Who this might be right for
Complement Mediated Bacterial Killing in Healthy Adults
University of Oxford 101
Early research (Phase 1)Looking for participantsNCT05318534
What this trial is testing

Safety, Tolerability, Pharmacokinetic, and Pharmacodynamic Study in Healthy Male and Female Subjects and Safety, Tolerability, Pharmacokinetics, and Pilot Efficacy Biomarkers in Subjects With Cold Agglutinin Disease

Who this might be right for
First in Man Study to Evaluate Initial Safety
Gliknik Inc. 70
Not applicableNot Yet RecruitingNCT07331259
What this trial is testing

CHART-C3G/CLNP023B12011

Who this might be right for
C3 GlomerulopathyComplement-mediated Kidney DiseaseProteinuria
Novartis Pharmaceuticals 83
Not applicableActive Not RecruitingNCT05985122
What this trial is testing

New Analytic Tools for aHUS and C3G Diagnosis

Who this might be right for
Hemolytic-Uremic SyndromeMembranoproliferative GlomerulonephritisHealthy
Mario Negri Institute for Pharmacological Research 180
Testing effectiveness (Phase 2)Looking for participantsNCT07522099
What this trial is testing

Chinese Adults With Kidney Disease

Who this might be right for
Immunoglobulin A Nephropathy (IgAN)Complement 3 Glomerulopathy (C3G)IC-MPGN
ADARx Pharmaceuticals, Inc. 30
Early research (Phase 1)Study completedNCT06797375
What this trial is testing

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics Study of RLYB116 in Healthy Participants

Who this might be right for
Hematologic DiseasesAutoimmune Diseases
Rallybio 16
Early research (Phase 1)Study completedNCT02502903
What this trial is testing

Safety, Tolerability and Activity of BIVV009 in Healthy Volunteers and Patients With Complement Mediated Disorders

Who this might be right for
Bullous Pemphigoid (BP)Cold Agglutinin Disease (CAD)Warm Autoimmune Hemolytic Anemia (WAIHA)+1 more
Bioverativ, a Sanofi company 122
Post-approval studies (Phase 4)Study completedNCT07290855
What this trial is testing

Evaluate the Safety and Efficacy of Icatibant in Patients With Bradykinin Induced Angioedema

Who this might be right for
Bradykinin-mediated AngioedemaHereditary Angioedema (HAE)
Nang Kuang Pharmaceutical Co., Ltd. 5
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06786338
What this trial is testing

SGB-9768 in Patients with Complement-mediated Kidney Diseases

Who this might be right for
IgA Nephropathy (IgAN)C3 GlomerulopathyIC-MPGN
Suzhou Sanegene Bio Inc. 38
Early research (Phase 1)Study completedNCT07040787
What this trial is testing

Investigation of Drug-drug Interaction of HRS-5965 With Clopidogrel and Clarithromycin in Healthy Subjects

Who this might be right for
Complement Mediated Glomerular DiseasesHemolytic Anemia
Chengdu Suncadia Medicine Co., Ltd. 36
Testing effectiveness (Phase 2)Looking for participantsNCT06853223
What this trial is testing

This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction

Who this might be right for
Primary Graft DysfunctionLung TransplantationAcute Lung Injury(ALI)+1 more
University of California, San Francisco 120
Not applicableAvailableNCT04288713
What this trial is testing

Eculizumab (Soliris) in Covid-19 Infected Patients

Who this might be right for
Coronavirus
Hudson Medical
Testing effectiveness (Phase 2)Study completedNCT03124368
What this trial is testing

A Proof-of-Mechanism Study to Determine the Effect of Danicopan on C3 Levels in Participants With C3G or IC-MPGN

Who this might be right for
C3 GlomerulonephritisDense Deposit DiseaseC3 Glomerulopathy+2 more
Alexion Pharmaceuticals, Inc. 6
Not applicableWithdrawnNCT05304091
What this trial is testing

Characterization of Rhythmicity Profiles of Bradykinin-mediated Angioedema Attacks Using a Tracking Smartphone Application.

Who this might be right for
Bradykinin-mediated Angioedema
University Hospital, Lille
Testing effectiveness (Phase 2)Ended earlyNCT03459443
What this trial is testing

A Proof of Concept Study for a 12 Month Treatment in Patients With C3G or IC-MPGN Treated With ACH-0144471

Who this might be right for
C3 GlomerulonephritisC3 GlomerulopathyImmune Complex Membranoproliferative Glomerulonephritis+2 more
Alexion Pharmaceuticals, Inc. 22
Testing effectiveness (Phase 2)Looking for participantsNCT06989359
What this trial is testing

Phase 2 Study of ADX-038 in Complement-Mediated Kidney Disease

Who this might be right for
IgANC3GComplement-mediated Kidney Disease+2 more
ADARx Pharmaceuticals, Inc. 45
Early research (Phase 1)Study completedNCT05937581
What this trial is testing

First-In-Human Study To Evaluate The Safety, Tolerability, Pharmacokinetics, And Pharmacodynamics Of Escalating Single And Multiple Doses Of CSL040 In Healthy Subjects

Who this might be right for
Complement-mediated Disorders
CSL Behring 62
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05517980
What this trial is testing

Efficacy, Safety, Pharmacokinetics, and Pharmacodynamics of KP104 to Treat Glomerulonephritis

Who this might be right for
Glomerulonephritis
Kira Pharmacenticals (US), LLC. 52
Testing effectiveness (Phase 2)Active Not RecruitingNCT05121376
What this trial is testing

A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema

Who this might be right for
Hereditary AngioedemaHAE
BioMarin Pharmaceutical 44
Early research (Phase 1)Active Not RecruitingNCT06209177
What this trial is testing

Study of ARO-CFB in Adult Healthy Volunteers

Who this might be right for
IgA Nephropathy
Arrowhead Pharmaceuticals 49
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