Large-scale testing (Phase 3)UnknownNCT00502632What this trial is testingDornase Alfa and Urokinase for Kids With Pleural EmpyemaWho this might be right forPleural Empyema Azienda Ospedaliera di Padova 94
Not applicableLooking for participantsNCT06434324What this trial is testingPleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic EffusionWho this might be right forPleural Infection Mayo Clinic 60
Large-scale testing (Phase 3)Ended earlyNCT00234208What this trial is testingEarly Medical Thoracoscopy Versus Simple Chest Tube Drainage in Complicated Parapneumonic Effusion and Pleural EmpyemaWho this might be right forComplicated Parapneumonic EffusionPleural Empyema University Hospital, Basel, Switzerland 2
Post-approval studies (Phase 4)Not Yet RecruitingNCT07592520What this trial is testingFlush, Lyse, OperateWho this might be right forComplicated Parapneumonic EffusionEmpyema, Pleural Dartmouth-Hitchcock Medical Center 30
Not applicableStudy completedNCT00468104What this trial is testingEfficacy and Safety of Activase (Ateplase) vs Placebo in Complicated Pleural Effusions (CPE)/EmpyemasWho this might be right forPleural Effusion Associated With Pulmonary InfectionBacterial Pleural Effusion Other Than Tuberculosis Midwest Pulmonary and Critical Care 100
Not applicableStudy completedNCT03583931What this trial is testingTreatment of Complicated Parapneumonic Effusion With Fibrinolytic Therapy Versus VATs DecorticationWho this might be right forParapneumonic EffusionEmpyema, PleuralCoagulopathy Denver Health and Hospital Authority 10
Post-approval studies (Phase 4)Looking for participantsNCT07095361What this trial is testingOnce Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or EmpyemaWho this might be right forPleural Infection BacterialPleural InfectionsPleural Infections and Inflammations+5 more University of North Carolina, Chapel Hill 270
Not applicableUnknownNCT00103766What this trial is testingAlteplase for Treatment of Empyema and Complicated Parapneumonic EffusionWho this might be right forEmpyemaPleural Effusion O'Brien, Jeana D., MD, FACP, FCCP 75
Not applicableLooking for participantsNCT06427538What this trial is testingChest Drain Regular Flushing in Complicated Parapneumonic Effusions and EmpyemasWho this might be right forEmpyema, PleuralPleural Infection Vanderbilt University Medical Center 96
Post-approval studies (Phase 4)Study completedNCT01246453What this trial is testingEfficacy and Security of Intrapleurally Alteplase vs Urokinase for the Treatment of Complicated Parapneumonic Effusion and EmpyemaWho this might be right forEmpyema, PleuralPleural EffusionPleural Diseases Hospital Universitari Vall d'Hebron Research Institute 204
Not applicableNot Yet RecruitingNCT07188714What this trial is testingVideo-assisted Thoracoscopic Surgery (VATS) Has Revolutionised Management of Complicated PPE, Our Study to Determine VATS Decortication Technique is Needed, Compared to VATS Debridement in PPE, Also RAPID Score and Pleural US Parameters Can Predict Which VATS Procedure is Needed.Who this might be right forParapneumonic Effussion Assiut University 95