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Results for “Constitutional Mismatch Repair Deficiency Syndrome”

39 trials

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Showing 20 of 39 results

Not applicableUnknownNCT03757247
What this trial is testing

Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation

Who this might be right for
Neurofibromatosis Type 1
Medical University Innsbruck 670
Not applicableNot Yet RecruitingNCT04774367
What this trial is testing

Evaluation of the Reliability of the Determination of MisMatch Repair Deficiency Status by Endoscopic Biopsies in Oesophagus and Gastric Adenocarcinoma.

Who this might be right for
Gastro-oesophageal Adenocarcinoma
Assistance Publique - Hôpitaux de Paris 300
Testing effectiveness (Phase 2)Looking for participantsNCT05729646
What this trial is testing

Perioperative Chemotherapy Plus Toripalimab for dMMR Locally Advanced Gastric or Esophagogastric Junction Adenocarcinoma

Who this might be right for
Adenocarcinoma of the StomachAdenocarcinoma of Esophagogastric JunctionMismatch Repair Deficiency
Yu jiren 90
Early research (Phase 1)Study completedNCT03652077
What this trial is testing

A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies

Who this might be right for
Cervical CancerGastric CancerStomach Cancer+18 more
Incyte Corporation 40
Not applicableLooking for participantsNCT05129605
What this trial is testing

Prostate Cancer Genetic Risk Evaluation and Screening Study

Who this might be right for
Prostatic NeoplasmProstate CancerBRCA2 Mutation+5 more
Massachusetts General Hospital 400
Early research (Phase 1)Active Not RecruitingNCT02359565
What this trial is testing

Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma

Who this might be right for
Constitutional Mismatch Repair Deficiency SyndromeLynch SyndromeMalignant Glioma+8 more
National Cancer Institute (NCI) 71
Testing effectiveness (Phase 2)Looking for participantsNCT03935893
What this trial is testing

Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers

Who this might be right for
Gastric CancerColorectal CancerPancreatic Cancer+7 more
Udai Kammula 240
Early research (Phase 1)Not Yet RecruitingNCT07385846
What this trial is testing

Pilot Study of Navigated Focused Ultrasound and Pembrolizumab in the Treatment of Recurrent WHO Grade 4 IDH-Wildtype Glioblastoma With Mismatch Repair Deficiency

Who this might be right for
GlioblastomaMismatch Repair Deficiency
Jennifer Leddon 8
Testing effectiveness (Phase 2)Looking for participantsNCT05200559
What this trial is testing

T-regulatory Cell Depletion with E7777 Combined with Pembrolizumab in Recurrent or Metastatic Solid Tumors

Who this might be right for
Epithelial Ovarian Cancer
Alexander B Olawaiye, MD 70
Testing effectiveness (Phase 2)Active Not RecruitingNCT03228667
What this trial is testing

QUILT-3.055: A Study of Combination Immunotherapies in Patients Who Have Previously Received Treatment With Immune Checkpoint Inhibitors

Who this might be right for
Non-Small Cell Lung CancerSmall Cell Lung CancerUrothelial Carcinoma+10 more
ImmunityBio, Inc. 40
Testing effectiveness (Phase 2)Looking for participantsNCT07140679
What this trial is testing

Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer

Who this might be right for
Localized Colon CarcinomaStage IIB Colon Cancer AJCC v8Stage IIC Colon Cancer AJCC v8+1 more
Emory University 40
Not applicableStudy completedNCT05257057
What this trial is testing

Frequency of Endometrial Cancer Precursors Associated with Lynch Syndrome

Who this might be right for
Lynch SyndromeEndometrial CancerEndometrial Hyperplasia+2 more
WellSpan Health 91
Testing effectiveness (Phase 2)Looking for participantsNCT05093231
What this trial is testing

Pembrolizumab With Olaparib as Combined Therapy in Metastatic Pancreatic Cancer

Who this might be right for
Pancreatic Cancer
Cambridge University Hospitals NHS Foundation Trust 20
Early research (Phase 1)Active Not RecruitingNCT05838768
What this trial is testing

Study of HRO761 Alone or in Combination in Cancer Patients With Specific DNA Alterations Called Microsatellite Instability or Mismatch Repair Deficiency.

Who this might be right for
MSIhi or dMMR Advanced Unresectable or Metastatic Solid Tumors, Including Colorectal Cancers
Novartis Pharmaceuticals 327
Early research (Phase 1)WithdrawnNCT04500548
What this trial is testing

Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study

Who this might be right for
Constitutional Mismatch Repair Deficiency SyndromeHematopoietic and Lymphoid Cell NeoplasmLynch Syndrome+9 more
National Cancer Institute (NCI)
Early research (Phase 1)Study completedNCT03053466
What this trial is testing

APL-501 Study for Select Advanced or Relapsed/Recurrent Solid Tumors

Who this might be right for
Solid TumorMicrosatellite InstabilityMismatch Repair Deficiency+1 more
Apollomics (Australia) Pty. Ltd. 30
Early research (Phase 1)Ended earlyNCT06034860
What this trial is testing

Study of MT-8421 as Monotherapy and in Combination With Nivolumab in Patients With Selected Advanced Solid Cancer Types

Who this might be right for
Non Small Cell Lung CancerHepatocellular CarcinomaMelanoma+8 more
Molecular Templates, Inc. 15
Not applicableNot Yet RecruitingNCT06549855
What this trial is testing

PD-1 Inhibitor Combined With Progesterone Treatment in FST for Patients With MMRd Endometrial Cancer

Who this might be right for
Endometrial CancerEndometrioid CarcinomaMismatch Repair Deficiency
Peking University People's Hospital 10
Not applicableLooking for participantsNCT06215677
What this trial is testing

Neoadjuvant Immunotherapy for T4 dMMR Colon Cancer

Who this might be right for
Colon CancerMismatch Repair DeficiencyImmunotherapy
Peking Union Medical College Hospital 18
Not applicableStudy completedNCT03460483
What this trial is testing

Universal Endometrial Cancer DNA Sequencing for Detection of Lynch Syndrome and Personalized Care

Who this might be right for
Endometrial AdenocarcinomaEndometrial CarcinomaLynch Syndrome+1 more
Ohio State University Comprehensive Cancer Center 1,001
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