Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Controlled Human Malaria Infection (CHMI)”

26 trials

Showing 20 of 26 results

Early research (Phase 1)Active Not RecruitingNCT06735209
What this trial is testing

First-in-Human PfSPZ-LARC2 Vaccination/CHMI

Who this might be right for
Malaria
National Institute of Allergy and Infectious Diseases (NIAID) 22
Early research (Phase 1)Ended earlyNCT05604521
What this trial is testing

Trial of PfSPZ Vaccine in Healthy Adults to Determine Safety, Tolerability and Efficacy Against Heterologous CHMI

Who this might be right for
MalariaMalaria,Falciparum
Sanaria Inc. 31
Early research (Phase 1)Study completedNCT03867331
What this trial is testing

To Assess the Safety, Immunogenicity and Efficacy of VLPM01 in Healthy, Malaria-Naïve Volunteers

Who this might be right for
Malaria,Falciparum
VLP Therapeutics 36
Early research (Phase 1)Study completedNCT03014258
What this trial is testing

A Systems Biology Approach to Malaria Immunity

Who this might be right for
Plasmodium Falciparum Infection
National Institute of Allergy and Infectious Diseases (NIAID) 27
Early research (Phase 1)Study completedNCT01624961
What this trial is testing

Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults

Who this might be right for
Malaria
Sanaria Inc. 30
Early research (Phase 1)Study completedNCT02174978
What this trial is testing

Phase 1 Clinical Trial With Controlled Human Malaria Infection (CHMI) to Evaluate the Safety and Efficacy of the Plasmodium Falciparum Vaccine Candidate FMP012 Administered Intramuscularly With AS01B Adjuvant System in Healthy Malaria-Naïve Adults

Who this might be right for
Malaria
U.S. Army Medical Research and Development Command 39
Early research (Phase 1)Study completedNCT05019729
What this trial is testing

Trial to Evaluate L9LS in Healthy Adults

Who this might be right for
Malaria
National Institute of Allergy and Infectious Diseases (NIAID) 32
Early research (Phase 1)UnknownNCT02739763
What this trial is testing

Controlled Human Malaria Infection in Semi-Immune Kenyan Adults. (CHMI-SIKA)

Who this might be right for
Malaria
University of Oxford 200
Early research (Phase 1)Study completedNCT04206332
What this trial is testing

Trial to Evaluate CIS43LS in Healthy Adults

Who this might be right for
Malaria
National Institute of Allergy and Infectious Diseases (NIAID) 71
Early research (Phase 1)Study completedNCT02704533
What this trial is testing

Sequential Optimization of Dose and Schedule of PfSPZ Vaccine

Who this might be right for
Malaria
Sanaria Inc. 45
Early research (Phase 1)Study completedNCT04966871
What this trial is testing

Safety, Tolerability and Efficacy of PfSPZ Vaccine Against Heterologous CHMI in US Malaria naïve Adults

Who this might be right for
Malaria
Sanaria Inc. 54
Early research (Phase 1)Study completedNCT02237586
What this trial is testing

Effect of Plasmodium Falciparum Exposure and Sickle Cell Trait on Infection Rates and Kinetics After IV Administration of PfSPZ Challenge

Who this might be right for
Plasmodium Falciparum MalariaMalaria
Sanaria Inc. 25
Early research (Phase 1)Study completedNCT03163121
What this trial is testing

Safety and Protective Efficacy of Genetically Attenuated PfSPZ-GA1 Vaccine in Healthy Dutch Volunteers

Who this might be right for
Malaria
Sanaria Inc. 67
Early research (Phase 1)Study completedNCT02015091
What this trial is testing

Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults

Who this might be right for
Malaria
National Institute of Allergy and Infectious Diseases (NIAID) 141
Early research (Phase 1)UnknownNCT04296279
What this trial is testing

A Trial For The Study of Falciparum Malaria Protein 014 Administered Via Intramuscular Injection in Healthy Adults

Who this might be right for
Vaccine Reaction
U.S. Army Medical Research and Development Command 46
Early research (Phase 1)Study completedNCT02132299
What this trial is testing

Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults

Who this might be right for
MalariaPlasmodium Falciparum Malaria
Sanaria Inc. 67
Early research (Phase 1)Study completedNCT01728701
What this trial is testing

Controlled Human Malaria Infection (CHMI) After Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chloroquine Prophylaxis

Who this might be right for
MalariaPlasmodium Falciparum
Sanaria Inc. 30
Early research (Phase 1)Study completedNCT03882528
What this trial is testing

Evaluate the Infectivity Equivalence of Current and New Lots of Plasmodium Falciparum Strain NF54

Who this might be right for
Malaria,Falciparum
U.S. Army Medical Research and Development Command 12
Early research (Phase 1)Study completedNCT02859350
What this trial is testing

Safety, Tolerability and Immunogenicity of PfSPZ Vaccine in an Age De-escalation Trial in Equatorial Guinea.

Who this might be right for
Malaria
Sanaria Inc. 135
Early research (Phase 1)Not Yet RecruitingNCT07124156
What this trial is testing

A Challenge Study to Assess the Blood-stage Efficacy of Full-length SUM-101 Malaria Vaccine Candidate

Who this might be right for
Malaria Fever
European Vaccine Initiative 24
Load More Results

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation