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Results for “Driver Mutation”

86 trials

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Showing 20 of 86 results

Testing effectiveness (Phase 2)UnknownNCT03646968
What this trial is testing

Study of Anlotinib Combined With Docetaxel in Non-Driver Mutation Non-squamous NSCLC: the Save Study

Who this might be right for
Non-Squamous Non Small Cell Lung Cancer
Yongchang Zhang 43
Testing effectiveness (Phase 2)Study completedNCT02889900
What this trial is testing

Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer

Who this might be right for
Recurrent Platinum Resistant Ovarian Cancer
AstraZeneca 62
Early research (Phase 1)Study completedNCT03101839
What this trial is testing

Phase I Dose-Escalation Study of AZD4785 in Patients With Advanced Solid Tumours

Who this might be right for
Non-Small Cell Lung CancerAdvanced Solid Tumours
AstraZeneca 28
Testing effectiveness (Phase 2)Looking for participantsNCT06305715
What this trial is testing

Radiation Prior to TKI to Delay Progression in Advanced Driver-Mutated Non-small Cell Lung Cancers (RadiaNCe Lung X)

Who this might be right for
Non Small Cell Lung Cancer
Medical College of Wisconsin 34
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Testing effectiveness (Phase 2)Ended earlyNCT02326844
What this trial is testing

BMN 673 (Talazoparib), an Oral PARP Inhibitor, in People With Deleterious BRCA1/2 Mutation-Associated Ovarian Cancer Who Have Had Prior PARP Inhibitor Treatment

Who this might be right for
Ovarian Cancer
National Cancer Institute (NCI) 3
Not applicableUnknownNCT06081270
What this trial is testing

Prospective Study on Resistance-associated Mutations in Metastatic Lung Cancer

Who this might be right for
Lung Cancer
University of Milano Bicocca 20
Early research (Phase 1)Study completedNCT04335890
What this trial is testing

IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal Melanoma

Who this might be right for
Melanoma, Uveal Metastatic
Hasumi International Research Foundation 17
Testing effectiveness (Phase 2)Looking for participantsNCT05277844
What this trial is testing

Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC

Who this might be right for
Oligometastatic DiseaseNon-small Cell Lung CancerDriver Mutation
Tata Memorial Hospital 106
Not applicableActive Not RecruitingNCT02760849
What this trial is testing

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Who this might be right for
Deleterious BARD1 Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+11 more
M.D. Anderson Cancer Center 374
Not applicableStudy completedNCT02982408
What this trial is testing

Impact of Overfeeding and Following Exercise Training in Individuals With and Without Increased Risk of Type 2 Diabetes

Who this might be right for
Type 2 Diabetes MellitusInsulin ResistanceDyslipidemia
Rigshospitalet, Denmark 48
Testing effectiveness (Phase 2)Looking for participantsNCT06501378
What this trial is testing

Cranial Radiotherapy Plus Chemoimmunotherapy in Untreated Driver-mutation Negative NSCLC With Active Brain Metastasis

Who this might be right for
NSCLC Stage IV
Fudan University 40
Not applicableStudy completedNCT02608346
What this trial is testing

Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)

Who this might be right for
Women With BRCA1 Germline Deleterious Mutation
Institut Curie 200
Not applicableLooking for participantsNCT03958565
What this trial is testing

Response of Bony Metastasis to Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancers With Actionable Driver Mutations.

Who this might be right for
Carcinoma, Non-Small-Cell Lung
University of Colorado, Denver 100
Early research (Phase 1)Active Not RecruitingNCT03586661
What this trial is testing

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Who this might be right for
Deleterious BRCA1 Gene MutationDeleterious BRCA2 Gene MutationEndometrial Adenocarcinoma+8 more
M.D. Anderson Cancer Center 31
Not applicableStudy completedNCT05697198
What this trial is testing

PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine

Who this might be right for
Lung CancerOvarian CancerUterine Cancer+10 more
Labcorp Corporation of America Holdings, Inc 1,429
Testing effectiveness (Phase 2)Study completedNCT03845296
What this trial is testing

Rucaparib in Treating Patients With Genomic LOH High and/or Deleterious BRCA1/2 Mutation Stage IV or Recurrent Non-small Cell Lung Cancer (A Lung-MAP Treatment Trial)

Who this might be right for
Deleterious BRCA1 Gene MutationDeleterious BRCA2 Gene MutationLoss of Heterozygosity+8 more
SWOG Cancer Research Network 64
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Testing effectiveness (Phase 2)Study completedNCT04144608
What this trial is testing

Toripalimab Combined With Double Platinum-based Chemotherapy for Initially Unresectable NSCLC

Who this might be right for
Advanced Non Small Cell Lung Cancer
Yongchang Zhang 40
Not applicableLooking for participantsNCT05835739
What this trial is testing

InheriteD brEast caNcer iTalian regIsTrY A Retrospective-prospective Observational Cohort Study to Evaluate Cancer Prevention Strategies in Women With a Deleterious Mutation in BRCA1-2

Who this might be right for
Breast Cancer
Centro di Riferimento Oncologico - Aviano 78
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