Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Driver Mutation”

85 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 85 results

Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Not applicableActive Not RecruitingNCT02760849
What this trial is testing

Surgery in Preventing Ovarian Cancer in Patients With Genetic Mutations

Who this might be right for
Deleterious BARD1 Gene MutationDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+11 more
M.D. Anderson Cancer Center 374
Not applicableLooking for participantsNCT06443684
What this trial is testing

Molecular Residual, Dynamic Monitoring and Recurrence of Stage III Driver Mutated NSCLC

Who this might be right for
Non Small Cell Lung Cancer
Shanghai Chest Hospital 305
Testing effectiveness (Phase 2)Study completedNCT02282345
What this trial is testing

Talazoparib Before Standard Therapy in Treating Patients With Invasive, BRCA-Mutated Breast Cancer

Who this might be right for
Breast AdenocarcinomaDeleterious BRCA1 Gene MutationDeleterious BRCA2 Gene Mutation+2 more
M.D. Anderson Cancer Center 36
Testing effectiveness (Phase 2)Looking for participantsNCT05277844
What this trial is testing

Local Consolidative Radiation Therapy Plus TKI Versus TKI Alone in Driver Mutated OM-NSCLC

Who this might be right for
Oligometastatic DiseaseNon-small Cell Lung CancerDriver Mutation
Tata Memorial Hospital 106
Testing effectiveness (Phase 2)Study completedNCT01989546
What this trial is testing

Pilot Trial of BMN 673, an Oral PARP Inhibitor, in Patients With Advanced Solid Tumors and Deleterious BRCA Mutations

Who this might be right for
Advanced Ovarian CancerPrimary Peritoneal CancerAdvanced Breast Cancer+1 more
National Cancer Institute (NCI) 9
Testing effectiveness (Phase 2)Active Not RecruitingNCT04053322
What this trial is testing

Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.

Who this might be right for
ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancera Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status
UNICANCER 172
Not applicableUnknownNCT03771079
What this trial is testing

MS Detection of Somatic Mutations in Hematological Malignancies

Who this might be right for
Hematological Malignancy
University Hospital, Strasbourg, France 200
Not applicableUnknownNCT02778854
What this trial is testing

Liquid Biopsy for Detection of Driver Mutation in NSCLC

Who this might be right for
Non Small Cell Lung Cancer
Chinese PLA General Hospital 200
Testing effectiveness (Phase 2)Ended earlyNCT03140670
What this trial is testing

Maintenance Rucaparib in BRCA1, BRCA2 or PALB2 Mutated Pancreatic Cancer That Has Not Progressed on Platinum-based Therapy

Who this might be right for
Pancreatic Cancer
Abramson Cancer Center at Penn Medicine 46
Not applicableStudy completedNCT03267641
What this trial is testing

Prospective Cohort Study on the Clinical Trajectory of Resected Hepatocellular Carcinoma

Who this might be right for
Hepatocellular Carcinoma
National Cancer Centre, Singapore 86
Not applicableLooking for participantsNCT06098690
What this trial is testing

Culturally Tailored HPV Psychoeducational Multimedia Intervention

Who this might be right for
Health Knowledge, Attitudes, PracticeVaccine-Preventable DiseasesIntention+1 more
University of Texas, El Paso 100
Testing effectiveness (Phase 2)UnknownNCT05005468
What this trial is testing

A Phase II Trial of Camrelizumab Combined With Famitinib for Adjuvant Treatment of Stage II-IIIA NSCLC.

Who this might be right for
NSCLC
Shanghai Chest Hospital 61
Not applicableStudy completedNCT02982408
What this trial is testing

Impact of Overfeeding and Following Exercise Training in Individuals With and Without Increased Risk of Type 2 Diabetes

Who this might be right for
Type 2 Diabetes MellitusInsulin ResistanceDyslipidemia
Rigshospitalet, Denmark 48
Not applicableActive Not RecruitingNCT06518018
What this trial is testing

Efficacy and Safety of High-Dose Rate Brachytherapy with Immunotherapy and Chemotherapy As Second-Line Treatment for Advanced Non-Small Cell Lung Cancer

Who this might be right for
Advanced Stage NSCLCSecond-line TreatmentPatients Without Targetable Driver Mutations
The First People's Hospital of Neijiang 80
Early research (Phase 1)UnknownNCT04335890
What this trial is testing

IKKb-matured, RNA-loaded Dendritic Cells for Metastasised Uveal Melanoma

Who this might be right for
Melanoma, Uveal Metastatic
Hasumi International Research Foundation 12
Early research (Phase 1)Active Not RecruitingNCT03586661
What this trial is testing

Niraparib and Copanlisib in Treating Patients With Recurrent Endometrial, Ovarian, Primary Peritoneal, or Fallopian Tube Cancer

Who this might be right for
Deleterious BRCA1 Gene MutationDeleterious BRCA2 Gene MutationEndometrial Adenocarcinoma+8 more
M.D. Anderson Cancer Center 31
Not applicableUnknownNCT03710629
What this trial is testing

Explore Treatment Regimens and Clinical Outcomes of the NSCLC Patients With Different Dirver Genes

Who this might be right for
Non-small Cell Lung Cancer
The First Affiliated Hospital of Guangzhou Medical University 750
Not applicableUnknownNCT04300361
What this trial is testing

Identifying Novel Variants in the DPYD Gene in Patients of Non-Western Descent

Who this might be right for
Neoplasms
Leiden University Medical Center 600
Testing effectiveness (Phase 2)Study completedNCT04144608
What this trial is testing

Toripalimab Combined With Double Platinum-based Chemotherapy for Initially Unresectable NSCLC

Who this might be right for
Advanced Non Small Cell Lung Cancer
Yongchang Zhang 40
Load More Results