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Results for “Endothelin”

125 trials

Showing 20 of 125 results

Not applicableActive Not RecruitingNCT02116335
What this trial is testing

Endothelin Receptor Function and Acute Stress

Who this might be right for
Hypertension
Augusta University 320
Testing effectiveness (Phase 2)Study completedNCT00586820
What this trial is testing

Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI

Who this might be right for
Myocardial Reperfusion Injury
Mayo Clinic 23
Testing effectiveness (Phase 2)Study completedNCT01205711
What this trial is testing

Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Cardiff University 111
Early research (Phase 1)Study completedNCT03679780
What this trial is testing

The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction

Who this might be right for
Cardiovascular DiseasesCardiovascular Risk FactorVasoconstriction
The University of Texas at Arlington 19
Testing effectiveness (Phase 2)UnknownNCT01658410
What this trial is testing

Short-term Endothelin A Receptor Blockade in Patients With On-pump CABG

Who this might be right for
Coronary Artery DiseaseAorto-coronary Bypass Grafting
Medical University of Vienna 120
Large-scale testing (Phase 3)Active Not RecruitingNCT06087835
What this trial is testing

Study to Investigate Efficacy, Safety, and Tolerability of Zibotentan/Dapagliflozin Compared to Dapagliflozin in Participants With Chronic Kidney Disease and High Proteinuria (ZENITH High Proteinuria)

Who this might be right for
Chronic Kidney Disease With High Proteinuria
AstraZeneca 1,835
Testing effectiveness (Phase 2)Study completedNCT04097314
What this trial is testing

Precision Medicine With Zibotentan in Microvascular Angina

Who this might be right for
Microvascular Angina
NHS Greater Glasgow and Clyde 225
Not applicableWithdrawnNCT00593905
What this trial is testing

Pharmacogenomics in Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Arterial HypertensionPulmonary HypertensionPAH WHO Group I
West Penn Allegheny Health System
Testing effectiveness (Phase 2)Study completedNCT04724837
What this trial is testing

Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)

Who this might be right for
Chronic Kidney Disease
AstraZeneca 542
Testing effectiveness (Phase 2)Ended earlyNCT01094067
What this trial is testing

Tezosentan in Patients With Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Arterial Hypertension
Idorsia Pharmaceuticals Ltd. 2
Large-scale testing (Phase 3)Ended earlyNCT00120328
What this trial is testing

To Determine the Effects of Avosentan on Doubling of Serum Creatinine, End Stage Renal Disease and Death in Diabetic Nephropathy

Who this might be right for
Diabetic Nephropathy
Speedel Pharma Ltd. 2,364
Not applicableUnknownNCT04732650
What this trial is testing

Real World Difference After Changing Medication From Nonselective to Selective Endothelin Receptor Antagonist in Stable Eisenmenger Syndrome

Who this might be right for
Eisenmenger Complex
Samsung Medical Center 40
Early research (Phase 1)WithdrawnNCT01119417
What this trial is testing

The Role of Endothelin in the Supine Hypertension of Autonomic Failure

Who this might be right for
HypertensionPure Autonomic FailureMultiple System Atrophy
Vanderbilt University
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266519
What this trial is testing

SIRIUS - Initial Combination Therapy With an Endothelin Receptor Antagonist, a Phosphodiesterase-5 Inhibitor and Sotatercept in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Arterial Hypertension (PAH)
Philipps University Marburg 25
Large-scale testing (Phase 3)Ended earlyNCT00796510
What this trial is testing

Study Providing Monotherapy (Sitaxsentan) And Combination Therapy (Sitaxsentan+Sildenafil) To Subjects With Pulmonary Arterial Hypertension (PAH) To Assess Long-Term Safety

Who this might be right for
Pulmonary Arterial HypertensionPulmonary Hypertension
Pfizer 3
Not applicableStudy completedNCT00275158
What this trial is testing

Glomerular Injury of Preeclampsia

Who this might be right for
Pre-Eclampsia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 45
Testing effectiveness (Phase 2)Study completedNCT00920764
What this trial is testing

Atrasentan on Reducing Albuminuria in Type 2 Diabetic Nephropathy Treated With Renin-Angiotensin System Inhibitors

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 92
Large-scale testing (Phase 3)UnknownNCT03841734
What this trial is testing

Study of the Benefit of Early Treatment With an Endothelin Inhibitor (Bosentan) in Patients With Sudden Blindness Due to Giant Cell Arteritis: CECIBO

Who this might be right for
Arteritis, Giant CellBlindness and Low Vision
Centre Hospitalier Universitaire de Nice 8
Large-scale testing (Phase 3)Study completedNCT01352065
What this trial is testing

Characterization and Detection of Prolonged Endothelin Receptors Antagonists Administration

Who this might be right for
Pulmonary Hypertension
Center for Health Sciences, Serbia 30
Large-scale testing (Phase 3)Looking for participantsNCT06819826
What this trial is testing

SC0062 Capsule for the Treatment of IgA Nephropathy with Proteinuria

Who this might be right for
IgA Nephropathy (IgAN)
Biocity Biopharmaceutics Co., Ltd. 360
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