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Results for “Endothelins”

125 trials

Showing 20 of 125 results

Post-approval studies (Phase 4)Looking for participantsNCT05955326
What this trial is testing

Study to Assess the Safety and Efficacy of Sovateltide in Patients With Acute Cerebral Ischemic Stroke

Who this might be right for
Acute Cerebral Ischemia
Pharmazz, Inc. 160
Testing effectiveness (Phase 2)Study completedNCT04097314
What this trial is testing

Precision Medicine With Zibotentan in Microvascular Angina

Who this might be right for
Microvascular Angina
NHS Greater Glasgow and Clyde 225
Testing effectiveness (Phase 2)Study completedNCT00423592
What this trial is testing

Phase 2 Study of Ambrisentan for Liver Function Test Rescue in Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Hypertension
Gilead Sciences 36
Not applicableStudy completedNCT01763892
What this trial is testing

Physiologic Mechanisms in Pediatric Traumatic Brain Injury (TBI)

Who this might be right for
Traumatic Brain Injury
Duke University 60
Large-scale testing (Phase 3)Ended earlyNCT01894022
What this trial is testing

A Open Label Study to Assess the Long-term Safety, Tolerability and Efficacy of Ambrisentan in Subjects With Inoperable Chronic Thromboembolic Pulmonary Hypertension (CTEPH)

Who this might be right for
Hypertension
GlaxoSmithKline 19
Not applicableStudy completedNCT02086253
What this trial is testing

Role of Endothelin-1 in Flow-mediated Dilatation

Who this might be right for
Healthy Conditions
University Hospital, Rouen 8
Large-scale testing (Phase 3)WithdrawnNCT00760916
What this trial is testing

FREEDOM DR: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor or as Monotherapy for the Treatment of Pulmonary Arterial Hypertension (PAH)

Who this might be right for
Pulmonary Hypertension
United Therapeutics
Testing effectiveness (Phase 2)Study completedNCT00502528
What this trial is testing

Endothelin Receptor Blockade in Acute ST-elevation Myocardial Infarction

Who this might be right for
ST-Elevation Myocardial Infarction
Medical University of Vienna 57
Testing effectiveness (Phase 2)Study completedNCT04724837
What this trial is testing

Zibotentan and Dapagliflozin for the Treatment of CKD (ZENITH-CKD Trial)

Who this might be right for
Chronic Kidney Disease
AstraZeneca 542
Testing effectiveness (Phase 2)Study completedNCT01424319
What this trial is testing

Reducing Residual Albuminuria in Subjects With Diabetes and Nephropathy With Atrasentan

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 58
Testing effectiveness (Phase 2)UnknownNCT01658410
What this trial is testing

Short-term Endothelin A Receptor Blockade in Patients With On-pump CABG

Who this might be right for
Coronary Artery DiseaseAorto-coronary Bypass Grafting
Medical University of Vienna 120
Early research (Phase 1)Study completedNCT00613691
What this trial is testing

A Phase I, Open-label, Ascending Dose Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of the Endothelin B Agonist, SPI-1620, in Patients With Recurrent or Progressive Carcinoma

Who this might be right for
Carcinoma
Spectrum Pharmaceuticals, Inc 36
Large-scale testing (Phase 3)Study completedNCT00325442
What this trial is testing

FREEDOM-C: Oral Treprostinil in Combination With an Endothelin Receptor Antagonist (ERA) and/or a Phosphodiesterase-5 (PDE-5) Inhibitor for the Treatment of Pulmonary Arterial Hypertension (PAH)

Who this might be right for
Pulmonary Hypertension
United Therapeutics 354
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266519
What this trial is testing

SIRIUS - Initial Combination Therapy With an Endothelin Receptor Antagonist, a Phosphodiesterase-5 Inhibitor and Sotatercept in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Arterial Hypertension (PAH)
Philipps University Marburg 25
Testing effectiveness (Phase 2)Study completedNCT01399580
What this trial is testing

A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 48
Not applicableStudy completedNCT00006071
What this trial is testing

Effects of Rosiglitazone on Blood Vessels in Patients With High Blood Pressure and High Cholesterol

Who this might be right for
HypercholesterolemiaHypertension
National Heart, Lung, and Blood Institute (NHLBI) 120
Very early researchStudy completedNCT01100736
What this trial is testing

Role of Endothelin-A (ETA) and Endothelin-B (ETB) Receptors in the Vasodilatory Response to Endothelin-3 (ET-3)

Who this might be right for
Pulmonary Arterial HypertensionVasodilationVasoconstriction
University of Edinburgh 10
Testing effectiveness (Phase 2)Study completedNCT01205711
What this trial is testing

Irinotecan Hydrochloride, Fluorouracil, and Leucovorin Calcium With or Without Zibotentan in Treating Patients With Metastatic Colorectal Cancer

Who this might be right for
Colorectal Cancer
Cardiff University 111
Testing effectiveness (Phase 2)Study completedNCT00586820
What this trial is testing

Role of Endothelin in Microvascular Dysfunction Following PCI for NSTEMI

Who this might be right for
Myocardial Reperfusion Injury
Mayo Clinic 23
Large-scale testing (Phase 3)Study completedNCT01224210
What this trial is testing

Ambrisentan in Patients With Porto-pulmonary Hypertension A Multicenter Open Label Trial

Who this might be right for
Portopulmonary Hypertension
Tufts Medical Center 30
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