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Results for “Endothelins”

126 trials

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Showing 20 of 126 results

Large-scale testing (Phase 3)Ended earlyNCT00796510
What this trial is testing

Study Providing Monotherapy (Sitaxsentan) And Combination Therapy (Sitaxsentan+Sildenafil) To Subjects With Pulmonary Arterial Hypertension (PAH) To Assess Long-Term Safety

Who this might be right for
Pulmonary Arterial HypertensionPulmonary Hypertension
Pfizer 3
Large-scale testing (Phase 3)Ended earlyNCT00879229
What this trial is testing

ARTEMIS-PH - Study of Ambrisentan in Subjects With Pulmonary Hypertension Associated With Idiopathic Pulmonary Fibrosis

Who this might be right for
Idiopathic Pulmonary FibrosisPulmonary Hypertension
Gilead Sciences 40
Post-approval studies (Phase 4)Study completedNCT00438503
What this trial is testing

Glucose in Dialysis Water in Diabetics With Chronic Renal Failure

Who this might be right for
Renal Failure, ChronicDiabetic Nephropathies
Regional Hospital Holstebro 18
Not applicableActive Not RecruitingNCT07670091
What this trial is testing

Endothelin Role In COronary Microcirculation

Who this might be right for
Coronary Microvascular Dysfunction (CMD)Angina Pectoris With Normal Coronary ArteriogramMicrovascular Angina
Liverpool University Hospitals NHS Foundation Trust 45
Testing effectiveness (Phase 2)Study completedNCT00759408
What this trial is testing

The Role of Endothelin in Pulmonary Hypertension

Who this might be right for
Pulmonary Hypertension
Brigham and Women's Hospital 38
Large-scale testing (Phase 3)Enrolling By InvitationNCT06432452
What this trial is testing

Efficacy of Endothelin Receptor Antagonism in Coronary Artery Spasm

Who this might be right for
Coronary Spasm
Radboud University Medical Center 100
Early research (Phase 1)Study completedNCT00701597
What this trial is testing

Effects of Non-Specific Endothelin-A Receptor Blockade on Ocular Blood Flow in Patients With Glaucoma

Who this might be right for
GlaucomaBlood Flow Velocity
Medical University of Vienna 28
Not applicableEnded earlyNCT02970851
What this trial is testing

Bosentan in Myocardium Metabolism and Perfusion Measured by 18F-FDG and 82Rb PET/CT on PAH and CTEPH

Who this might be right for
Myocardial DysfunctionEndothelial Dysfunction
University of Lausanne Hospitals 2
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06072326
What this trial is testing

DApagliflozin SC0062 and Prevention of Renal Injury; a Randomized Evaluation

Who this might be right for
Type 1 Diabetes Mellitus With Diabetic Nephropathy
University Medical Center Groningen 36
Testing effectiveness (Phase 2)Study completedNCT00738049
What this trial is testing

Darusentan Effect on PET Uptake Heterogeneity

Who this might be right for
Coronary Artery DiseaseEndothelial Dysfunction
K.Lance Gould 40
Testing effectiveness (Phase 2)Active Not RecruitingNCT06942910
What this trial is testing

Investigate the Effects of Zibotentan/Dapagliflozin Combination Compared to Dapagliflozin Alone in Adult Participants With Chronic Kidney Disease and High Proteinuria

Who this might be right for
Chronic Kidney Disease With High Proteinuria
AstraZeneca 224
Very early researchLooking for participantsNCT06811831
What this trial is testing

Evaluation of the Efficacy of MACitentan in the Treatment of CoronaryMICrovascular Angina (MACMIC)

Who this might be right for
Coronary Microvascular AnginaMacitentan
China-Japan Friendship Hospital 30
Not applicableStudy completedNCT04152005
What this trial is testing

Endothelin Concentrations in a Population With Cardiovascular Disease and Periodonitis

Who this might be right for
Serum; Disease
University of Messina 165
Very early researchActive Not RecruitingNCT03583866
What this trial is testing

Adiposity and Endothelin Receptor Function

Who this might be right for
Hypertension
Augusta University 25
Not applicableUnknownNCT01168141
What this trial is testing

Window Study of ZD4054 in Metastatic Prostate Cancer

Who this might be right for
Prostate CancerMetastasis
The Christie NHS Foundation Trust 30
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07266519
What this trial is testing

SIRIUS - Initial Combination Therapy With an Endothelin Receptor Antagonist, a Phosphodiesterase-5 Inhibitor and Sotatercept in Patients With Newly Diagnosed Pulmonary Arterial Hypertension

Who this might be right for
Pulmonary Arterial Hypertension (PAH)
Philipps University Marburg 25
Large-scale testing (Phase 3)WithdrawnNCT01458236
What this trial is testing

A Multinational, Multicenter, Study to Assess the Efficacy and Safety of BPS-314d-MR in Subjects With Pulmonary Arterial Hypertension Currently Receiving Treatment With an Endothelin Receptor Antagonist and/or a Phosphodiesterase-5 Inhibitor

Who this might be right for
Pulmonary Arterial Hypertension
Lung Biotechnology PBC
Not applicableStudy completedNCT00989911
What this trial is testing

Endothelin Blockade in Patients With Single Ventricle Physiology

Who this might be right for
Congenital Heart Disease
University of California, Los Angeles 10
Not applicableStudy completedNCT04508998
What this trial is testing

PRIZE ET Sub-Study

Who this might be right for
Microvascular Angina
Papworth Hospital NHS Foundation Trust 26
Testing effectiveness (Phase 2)Study completedNCT01399580
What this trial is testing

A Prospective, Double-Blind, Placebo-Controlled, Multicenter Study to Evaluate Efficacy and Safety of Atrasentan, Including Thoracic Bioimpedance, in Type 2 Diabetic Subjects With Nephropathy

Who this might be right for
Chronic Kidney DiseaseDiabetic Nephropathy
AbbVie (prior sponsor, Abbott) 48
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