Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • About
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Enzyme Deficiency”

72 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 72 results

Testing effectiveness (Phase 2)Looking for participantsNCT05027945
What this trial is testing

A Phase II Study of Allogeneic Hematopoietic Stem Cell Transplant for Subjects With VEXAS (Vacuoles, E1 Enzyme, X-linked, Autoinflammatory, Somatic) Syndrome

Who this might be right for
ImmunodeficiencyHematopoietic Stem Cell Transplantation
National Cancer Institute (NCI) 54
Early research (Phase 1)Study completedNCT01554800
What this trial is testing

Effect of ACP-501 on Safety, Tolerability, Pharmacokinetics and Pharmacodynamics in Subjects With Coronary Artery Disease

Who this might be right for
Coronary Artery DiseaseAtherosclerosis
MedImmune LLC 16
Early research (Phase 1)Study completedNCT01881984
What this trial is testing

Use of Ravicti™ in Patients With MCAD Deficiency With the 985A>G (K304E) Mutation

Who this might be right for
Medium-chain Acyl-CoA Dehydrogenase (MCAD) Deficiency
University of Pittsburgh 4
Not applicableEnded earlyNCT01547923
What this trial is testing

Pre-therapeutic Identification of Dihydropyrimidine Dehydrogenase Gene (DPD) Deficiency for Predicting Toxicity to Fluoropyrimidines

Who this might be right for
Colorectal CancerIntravenous 5 Fluorouracile
Institut Cancerologie de l'Ouest 1,142
Not applicableStudy completedNCT02191358
What this trial is testing

YouScript IMPACT Registry

Who this might be right for
Adverse Drug EventsAdverse Drug ReactionsDrug Interaction Potentiation+10 more
Genelex Corporation 800
Early research (Phase 1)Ended earlyNCT02795325
What this trial is testing

DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1)

Who this might be right for
Primary Hyperoxaluria Type 1
Dicerna Pharmaceuticals, Inc., a Novo Nordisk company 41
Not applicableLooking for participantsNCT04885179
What this trial is testing

SPL Insufficiency Syndrome (SPLIS)/NPHS14: a SPLIS Observational Study and Patient Registry (International)

Who this might be right for
SphingolipidosesEnzyme Deficiency
University of California, San Francisco 120
Not applicableLooking for participantsNCT01665326
What this trial is testing

Determination of CRIM Status and Longitudinal Follow-up of Individuals With Pompe Disease

Who this might be right for
Pompe Disease
Duke University 400
Not applicableUnknownNCT05300360
What this trial is testing

Prevalence of Adenosine Deaminase (ADA) Enzyme Deficiency Disease in Adult Patients With Pulmonary Alveolar Proteinosis

Who this might be right for
Pulmonary Alveolar Proteinosis
TRPHARM 15
Testing effectiveness (Phase 2)Study completedNCT00005931
What this trial is testing

SU5416 in Patients With AIDS-Related Kaposi's Sarcoma Who Have Not Responded to Treatment

Who this might be right for
Sarcoma, KaposiHIV Infections
SUGEN 30
Early research (Phase 1)Study completedNCT00638547
What this trial is testing

Intrathecal Enzyme Replacement for Hurler Syndrome

Who this might be right for
Hurler Syndrome
Masonic Cancer Center, University of Minnesota 26
Early research (Phase 1)Not Yet RecruitingNCT07354724
What this trial is testing

Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of DNL952 in Adult Participants With Late-Onset Pompe Disease

Who this might be right for
Late-onset Pompe Disease
Denali Therapeutics Inc. 32
Not applicableStudy completedNCT00328159
What this trial is testing

Nutritional Therapy of the Deficits of Oxidation Mitochondrial of the Fatty Acids

Who this might be right for
Inborn Errors of Metabolism
Assistance Publique - Hôpitaux de Paris 20
Not applicableLooking for participantsNCT07088302
What this trial is testing

Effect OF Lactase Enzyme Supplements ON Intolerance IN Preterm Neonates

Who this might be right for
PrematureFeeding DisordersLactase Deficiency, Congenital
Alexandria University 120
Large-scale testing (Phase 3)Study completedNCT00006327
What this trial is testing

Effectiveness of AIDSVAX B/E Vaccine in Intravenous Drug Users in Bangkok, Thailand

Who this might be right for
HIV InfectionsHIV Seronegativity
VaxGen 2,500
Not applicableStudy completedNCT04669106
What this trial is testing

Mineral and Enzyme Deficiency Diseases Associated With Nutritional Diseases in Society

Who this might be right for
Nutrient Deficiency
Universitas Sumatera Utara 180
Testing effectiveness (Phase 2)UnknownNCT04556071
What this trial is testing

Efficacy and Safety of Niraparib Combined With Bevacizumab in Platinum Refractory/Resistant Recurrent Ovarian Cancer

Who this might be right for
Ovarian NeoplasmsFallopian Tube NeoplasmsEndocrine Gland Neoplasms+21 more
Xiaoxiang Chen 32
Testing effectiveness (Phase 2)Looking for participantsNCT06887777
What this trial is testing

Efficacy and Safety of the Treatment of Pyruvate Dehydrogenase Deficiency Patients With Glycerol Phenylbutyrate (RAVICTI)

Who this might be right for
Pyruvate Dehydrogenase Complex Deficiency Disease
Assistance Publique - Hôpitaux de Paris 15
Not applicableStudy completedNCT00555633
What this trial is testing

Use of an SPF30 Sunscreen and an After-sun-lotion in Skin Cancer Risk Patients

Who this might be right for
Skin CancerXeroderma PigmentosumBasal Cell Nevus Syndrome
Medical University of Graz 13
Not applicableEnded earlyNCT00207948
What this trial is testing

Optimizing Antiretroviral Therapy in HIV-Infected Children and Adolescents

Who this might be right for
HIV Infections
Children's National Research Institute 4
Load More Results