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Results for “FXR”

29 trials

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Showing 20 of 29 results

Testing effectiveness (Phase 2)Study completedNCT01265498
What this trial is testing

The Farnesoid X Receptor (FXR) Ligand Obeticholic Acid in NASH Treatment Trial(FLINT)

Who this might be right for
Nonalcoholic Fatty Liver Disease (NAFLD)Nonalcoholic Steatohepatitis (NASH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 283
Early research (Phase 1)Study completedNCT03976687
What this trial is testing

Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of EYP001a in Healthy Volunteers and Nonalcoholic Steatohepatitis Patients

Who this might be right for
NASH - Nonalcoholic SteatohepatitisHealthy
Enyo Pharma 16
Testing effectiveness (Phase 2)Study completedNCT04328077
What this trial is testing

LIFT Study: A Safety, Tolerability, Efficacy, and Pharmacokinetics Study of TERN-101 in Subjects With Non-Cirrhotic Non-Alcoholic Steatohepatitis (NASH)

Who this might be right for
NASH - Nonalcoholic Steatohepatitis
Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 101
Not applicableUnknownNCT05740631
What this trial is testing

The Effect of Obeticholic Acid in Healthy Volunteers

Who this might be right for
Healthy
Universitaire Ziekenhuizen KU Leuven 12
Early research (Phase 1)Study completedNCT04965337
What this trial is testing

Study to Evaluate Safety, Tolerability and Pharmacokinetics of ASC42 in Chinese Healthy Subjects

Who this might be right for
Healthy
Ascletis Pharmaceuticals Co., Ltd. 30
Early research (Phase 1)UnknownNCT02532335
What this trial is testing

Obeticholic Acid in Morbidly Obese Patients and Healthy Volunteers

Who this might be right for
Obesity
Sahlgrenska University Hospital 40
Testing effectiveness (Phase 2)Ended earlyNCT02855164
What this trial is testing

Study of Safety and Efficacy of Tropifexor (LJN452) in Patients With Non-alcoholic Steatohepatitis (NASH)

Who this might be right for
Non-alcoholic Steatohepatitis (NASH)
Novartis Pharmaceuticals 350
Testing effectiveness (Phase 2)Study completedNCT04365933
What this trial is testing

The Oral Farnesoid X Receptor Modulator EYP001a to Assess Its Safety and Anti-viral Effect in Chronic Hepatitis B Patients in Combination With Pegylated Interferon alpha2a Alone and With Entecavir

Who this might be right for
Hepatitis B, Chronic
Enyo Pharma 20
Not applicableEnded earlyNCT05219916
What this trial is testing

Selection of Farnesoid X Receptor (FXR) Ligands on the Reactivation of Latent HIV Proviruses

Who this might be right for
Human Immunodeficiency Virus I Infection
Hospices Civils de Lyon 17
Early research (Phase 1)Study completedNCT04408937
What this trial is testing

The Purpose of This Study is to Investigate Safety and Tolerability of Tropifexor.

Who this might be right for
Liver Disease
Novartis Pharmaceuticals 89
Testing effectiveness (Phase 2)UnknownNCT04702490
What this trial is testing

Study to Evaluate MET409 Alone or in Combination With Empagliflozin in Patients With Type 2 Diabetes and NASH

Who this might be right for
NASHNASH - Nonalcoholic SteatohepatitisType 2 Diabetes+5 more
Metacrine, Inc. 120
Testing effectiveness (Phase 2)Study completedNCT01999101
What this trial is testing

Safety Pilot Study of Farnesoid X Receptor (FXR) Agonist in Non-alcoholic Fatty Liver Disease (NAFLD) Patients

Who this might be right for
Non Alcoholic Fatty Liver Disease
Phenex Pharmaceuticals AG 12
Early research (Phase 1)Study completedNCT05118516
What this trial is testing

Safety, Tolerability, and Pharmacokinetics of ASC43F, a Fixed Dose Combination Tablet in Healthy Subjects

Who this might be right for
Healthy Volunteer
Gannex Pharma Co., Ltd. 8
Testing effectiveness (Phase 2)Study completedNCT05415722
What this trial is testing

DUET Study: A Clinical Study to Evaluate the Safety, Efficacy, Pharmacokinetics and Pharmacodynamics of Orally Administered TERN-501 as Monotherapy and in Combination With TERN-101 in Noncirrhotic Adults With Presumed Non-Alcoholic Steatohepatitis

Who this might be right for
NASH - Nonalcoholic Steatohepatitis
Terns, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) 162
Testing effectiveness (Phase 2)Study completedNCT01585025
What this trial is testing

Obeticholic Acid in Bile Acid Diarrhoea

Who this might be right for
Primary Bile Acid MalabsorptionSecondary Bile Acid MalabsorptionChronic Diarrhoea
Imperial College Healthcare NHS Trust 35
Not applicableStudy completedNCT03618862
What this trial is testing

Study of the Effects of Farnesoid X Receptor (FXR) Ligands on the Reactivation of Latent Provirus

Who this might be right for
Hiv
Hospices Civils de Lyon 38
Testing effectiveness (Phase 2)Ended earlyNCT05639543
What this trial is testing

FXR Effect on Severe Alcohol-Associated Hepatitis (FRESH) Study

Who this might be right for
Alcohol Associated Hepatitis
Intercept Pharmaceuticals 67
Early research (Phase 1)Study completedNCT03320616
What this trial is testing

EYP001a Food Effect Study in Subjects With Chronic Hepatitis B Virus (HBV) Infection

Who this might be right for
Hepatitis B, Chronic
Enyo Pharma 11
Not applicableStudy completedNCT00422006
What this trial is testing

Study of the Role of PCSK9 and FXR in the Physiopathology of the Joint Dyslipidemia Associated to the Human Immunoresistance

Who this might be right for
Obesity
Nantes University Hospital 111
Very early researchStudy completedNCT00465751
What this trial is testing

Effects of FXR Activation on Hepatic Lipid and Glucose Metabolism

Who this might be right for
Metabolic SyndromeFamilial HypertriglyceridemiaFamilial Combined Hyperlipidemia
University Hospital, Basel, Switzerland 30
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