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Results for “Factor XI”

25 trials

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Showing 20 of 25 results

Large-scale testing (Phase 3)Looking for participantsNCT07213778
What this trial is testing

REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

Who this might be right for
Symptomatic Venous Thromboembolism (VTE)
Regeneron Pharmaceuticals 2,000
Testing effectiveness (Phase 2)Active Not RecruitingNCT06299111
What this trial is testing

A Trial to Learn How Well REGN9933 and REGN7508 Work for Preventing Blood Clots, and How Safe They Are, in Adults Who Have a Peripherally Inserted Central Catheter (PICC)

Who this might be right for
Venous Thromboembolism
Regeneron Pharmaceuticals 195
Testing effectiveness (Phase 2)Study completedNCT03358030
What this trial is testing

ISIS 416858 Administered Subcutaneously to Participants With End-Stage Renal Disease (ESRD) on Hemodialysis

Who this might be right for
End-stage Renal Disease (ESRD)
Ionis Pharmaceuticals, Inc. 213
Not applicableStudy completedNCT03165643
What this trial is testing

The DNA Methylation of ARHGEF11 in Macrosomia

Who this might be right for
Gestational DiabetesDiabetesMacrosomia, Fetal
Peking University First Hospital 239
Not applicableUnknownNCT01114074
What this trial is testing

Thrombus Formation Under Different Flow-conditions

Who this might be right for
Thrombosis
Maastricht University Medical Center 46
Testing effectiveness (Phase 2)Study completedNCT05027074
What this trial is testing

Global Study of MK-2060 (Anti-Factor XI Monoclonal Antibody) in Participants With End Stage Renal Disease Receiving Hemodialysis (FXI Hemodialysis Study) (MK-2060-007)

Who this might be right for
End-Stage Renal DiseaseEnd-Stage Kidney DiseaseKidney Failure, Chronic
Merck Sharp & Dohme LLC 506
Not applicableUnknownNCT01538160
What this trial is testing

A Single and Low Dose of Recombinant Factor VIIa in Patients With Severe Factor XI Deficiency Undergoing Surgery

Who this might be right for
Hemophilia C
Sheba Medical Center 15
Large-scale testing (Phase 3)Not Yet RecruitingNCT07318610
What this trial is testing

Reducing Adverse Vascular Outcomes With Factor XI Inhibition in Adult Participants With Peripheral Artery Disease

Who this might be right for
Peripheral Artery Disease (PAD)
Regeneron Pharmaceuticals 7,050
Testing effectiveness (Phase 2)Active Not RecruitingNCT04755283
What this trial is testing

Safety and Tolerability of Abelacimab (MAA868) vs. Rivaroxaban in Patients With Atrial Fibrillation

Who this might be right for
Atrial Fibrillation (AF)Stroke
Anthos Therapeutics, Inc. 1,287
Large-scale testing (Phase 3)Looking for participantsNCT07015905
What this trial is testing

REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults

Who this might be right for
Venous Thromboembolism (VTE)
Regeneron Pharmaceuticals 2,000
Early research (Phase 1)Study completedNCT05102136
What this trial is testing

Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of REGN9933 in Adult Healthy Volunteers

Who this might be right for
Healthy Volunteers
Regeneron Pharmaceuticals 56
Early research (Phase 1)Study completedNCT05603195
What this trial is testing

A Trial to Learn if Single Ascending Intravenous (IV) Doses of REGN7508 Are Safe and Well Tolerated, and How it Works in the Body of Healthy Adult Participants

Who this might be right for
Healthy Volunteer
Regeneron Pharmaceuticals 80
Testing effectiveness (Phase 2)Active Not RecruitingNCT06180889
What this trial is testing

Factor XI inhibiTion for the Prevention of Venous Thromboembolism in Patients Undergoing Total Knee Arthroplasty

Who this might be right for
Knee Arthroplasty, Total
Suzhou Alphamab Co., Ltd. 241
Testing effectiveness (Phase 2)WithdrawnNCT03398434
What this trial is testing

Efficacy and Safety of MAA868 in Patients With Atrial Fibrillation

Who this might be right for
Atrial Fibrillation
Novartis Pharmaceuticals
Not applicableNo Longer AvailableNCT01701947
What this trial is testing

HEMOLEVEN® Expanded Access Program Prevention of Surgical/Postpartum Hemorrhage Severe Inherited Factor XI Deficiency

Who this might be right for
Wound; Rupture, Surgery, Cesarean SectionPostpartum HemorrhageSurgery
Laboratoire français de Fractionnement et de Biotechnologies
Early research (Phase 1)Study completedNCT02902679
What this trial is testing

Evaluate the Safety and Pharmacokinetics of BMS-986177 in Participants With End-stage Renal Dysfunction on Chronic Stable Hemodialysis Treatment

Who this might be right for
ThrombosisFactor XIRenal Impairment+1 more
Bristol-Myers Squibb 6
Not applicableUnknownNCT02785718
What this trial is testing

The Proteins of the Contact Activation System

Who this might be right for
Factor XI DeficiencyFactor XII Deficiency
Hospices Civils de Lyon 18
Testing effectiveness (Phase 2)Study completedNCT04534114
What this trial is testing

Factor XI LICA to Reduce Events Such as Heart Attack and Stroke in Patients Whose Kidneys Are no Longer Able to Work as They Should and Require Treatment to Filter Wastes From the Blood: Focus is on the Safety of BAY2976217 and the Way the Body Absorbs, Distributes and Removes the Study Drug

Who this might be right for
End Stage Renal Disease Requiring Hemodialysis
Bayer 307
Not applicableStudy completedNCT00890812
What this trial is testing

Factor XI Levels in Acute Ischemic Stroke

Who this might be right for
Stroke
University of Utah 450
Early research (Phase 1)Study completedNCT06444178
What this trial is testing

Assessment of Gastrointestinal Blood Loss After Receiving Aspirin or Aspirin Plus Rivaroxaban, or Aspirin Plus REGN9933, or Aspirin Plus REGN7508 in Healthy Adult Participants

Who this might be right for
Healthy Volunteers
Regeneron Pharmaceuticals 224
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