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Results for “First or Second Line Therapy”

153 trials

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Showing 20 of 153 results

Not applicableStudy completedNCT06558084
What this trial is testing

Real-World Clinical Outcomes and Toxicity in Metastatic Breast Cancer Patients Treated With First or Second Line CDK 4/6 Inhibitors and Endocrine Therapy

Who this might be right for
Toxicity, DrugProgression, Disease
Ain Shams University 64
Early research (Phase 1)Ended earlyNCT01238029
What this trial is testing

Dose Finding Study for Combination of Capecitabine, Lapatinib and Vinorelbine in Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerHER2 PositiveFirst or Second Line Therapy+1 more
Sponsor GmbH 12
Testing effectiveness (Phase 2)Looking for participantsNCT06413745
What this trial is testing

Phase II Clinical Study of SHR-A1811 in Patients With HER2 Expression / Amplification of Locally Advanced Unresectable or Recurrent Metastatic Biliary Tract Cancer

Who this might be right for
HER2 Expression / Amplification in Patients With Biliary Tract Cancer
Jiangsu HengRui Medicine Co., Ltd. 65
Not applicableWithdrawnNCT03161613
What this trial is testing

Study to Assess the Safety of Nivolumab in the Treatment of Metastatic Melanoma, Lung Cancer, Renal Cancer, Squamous Cell Carcinoma of the Head and Neck, and Chronic Hodgkin Lymphoma in Adults in Mexico

Who this might be right for
Multiple Indications Cancer
Bristol-Myers Squibb
Testing effectiveness (Phase 2)UnknownNCT05322499
What this trial is testing

Phase II Clinical Study of Camrelizumab Combined With Chemotherapy or Anlotinib in Advanced Esophageal Squamous Cell Cancer

Who this might be right for
Stage IV Esophagus Squamous Cell Carcinoma
Zhejiang Cancer Hospital 80
Early research (Phase 1)Active Not RecruitingNCT06542731
What this trial is testing

An Open-label, Uncontrolled Study of ONO-4578 and ONO-4538 in Combination With Standard-of-care Docetaxel and Ramucirumab as Second-line Therapy in Patients With Advanced or Recurrent Non-small Cell Lung Cancer

Who this might be right for
Non-small Cell Lung Cancer
Ono Pharmaceutical Co. Ltd 42
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07193160
What this trial is testing

Sacituzumab Tirumotecan in Combination With Furmonertinib as Second-line Treatment for EGFR-mutant Advanced or Metastatic NSCLC After Failure of First-line Third-generation EGFR-TKI Therapy

Who this might be right for
NSCLC (Non-small Cell Lung Cancer)
Fudan University 45
Testing effectiveness (Phase 2)Not Yet RecruitingNCT06592612
What this trial is testing

Second-line Systemic Therapy Combined with SBRT for HCC with Oligoprogression After Standard First-line Systemic Treatment

Who this might be right for
Hepatocellular CarcinomaOligoprogression
Sun Yat-sen University 70
Large-scale testing (Phase 3)Study completedNCT00003917
What this trial is testing

Topotecan in Treating Patients With Relapsed Small Cell Lung Cancer

Who this might be right for
Lung Cancer
Case Comprehensive Cancer Center 4
Large-scale testing (Phase 3)Ended earlyNCT02766140
What this trial is testing

SHR1020 Plus Docetaxel as Compared to Placebo Plus Docetaxel in 2nd Line Non Squamous Non Small Cell Lung Cancer

Who this might be right for
Non Squamous Non Small Cell Lung
Jiangsu HengRui Medicine Co., Ltd. 12
Large-scale testing (Phase 3)Ended earlyNCT00968968
What this trial is testing

Continued HER2 Suppression With Lapatinib Plus Trastuzumab Versus Trastuzumab Alone

Who this might be right for
Cancer
Novartis Pharmaceuticals 37
Testing effectiveness (Phase 2)Ended earlyNCT00727207
What this trial is testing

Everolimus in Treating Older Patients With Mantle Cell Lymphoma Previously Treated With First-Line or Second-Line Chemotherapy

Who this might be right for
Lymphoma
Technical University of Munich 35
Testing effectiveness (Phase 2)Study completedNCT01801137
What this trial is testing

The Efficacy of RAD 001 as Second Line Therapy in Patients With Transitional Cell Carcinoma TCC of the Urothelium

Who this might be right for
Urothelial Cancer
Hopital Foch 54
Large-scale testing (Phase 3)Study completedNCT02898077
What this trial is testing

Paclitaxel With or Without Ramucirumab (LY3009806) in Participants With Gastric or Gastroesophageal Cancer

Who this might be right for
Gastroesophageal Junction AdenocarcinomaGastric Adenocarcinoma
Eli Lilly and Company 440
Testing effectiveness (Phase 2)Looking for participantsNCT04038502
What this trial is testing

Carboplatin or Olaparib for BRcA Deficient Prostate Cancer

Who this might be right for
Metastatic Castrate Resistant Prostate CancerBARD1, BRCA1, BRCA2, BRIP1, CHEK1, FANCL, PALB2RAD51B, RAD51C, RAD51D, or RAD54L Mutations
VA Office of Research and Development 100
Testing effectiveness (Phase 2)Study completedNCT01954745
What this trial is testing

Cabozantinib (XL-184) Monotherapy for Advanced Cholangiocarcinoma

Who this might be right for
Bile Duct CancerIntrahepatic CholangiocarcinomaCholangiocarcinoma of the Extrahepatic Bile Duct
Massachusetts General Hospital 19
Early research (Phase 1)Study completedNCT00661739
What this trial is testing

A Multicentre Phase I-II Study to Investigate the Combination of Bendamustine With Weekly Paclitaxel as First or Second Line Therapy in Patients With Metastatic Breast Cancer

Who this might be right for
Metastatic Breast Cancer
GBG Forschungs GmbH 38
Early research (Phase 1)Study completedNCT00507091
What this trial is testing

Phase I Irinotecan, 5-Fluorouracil and Leucovorin Combination

Who this might be right for
MetastaticColorectalAdenocarcinoma
Genzyme, a Sanofi Company 24
Post-approval studies (Phase 4)Study completedNCT02208843
What this trial is testing

Afatinib as Second-line Therapy for Lung Cancer With Epidermal Growth Factor Receptor (EGFR) Mutation

Who this might be right for
Carcinoma, Non-Small-Cell Lung
Boehringer Ingelheim 60
Testing effectiveness (Phase 2)Study completedNCT02954055
What this trial is testing

MEtronomic TrEatment Option in Advanced bReast cAncer

Who this might be right for
Breast Cancer
ETOP IBCSG Partners Foundation 140
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