Early research (Phase 1)UnknownNCT03645200What this trial is testingTreatment of Carrying TP53 Harmful MutationsWho this might be right forAdvanced Cancer Tianjin Medical University Second Hospital 60
Early research (Phase 1)Study completedNCT01225536What this trial is testingDose Escalation Study of ARQ 736 in Adult Subjects With Advanced Solid Tumors Harboring BRAF and/or NRAS MutationsWho this might be right forSolid Tumor ArQule, Inc., a subsidiary of Merck Sharp & Dohme LLC, a subsidiary of Merck & Co., Inc. (Rahway, NJ USA) 24
Testing effectiveness (Phase 2)Study completedNCT00588445What this trial is testingPhase II Trial to Correlate Radiographic Response Induced By Gefitinib With Mutations in the Protein-Tyrosine Kinase Domain of the EGF Receptor GeneWho this might be right forLung CancerNon-small Cell Lung CancerBronchioloalveolar Cancer Memorial Sloan Kettering Cancer Center 65
Testing effectiveness (Phase 2)Looking for participantsNCT04090567What this trial is testingOlaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast CancerWho this might be right forAdvanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Looking for participantsNCT07505173What this trial is testingHippocampus-Protective Radiotherapy Combined With Osimertinib for Symptomatic Brain Metastases in EGFR-Mutated Lung CancerWho this might be right forNaive Advanced Non-small Cell Lung Cancer With EGFR-sensitive Mutations (EGFR Exon 19 Deletion and Exon 21 L858R Mutation) and Symptomatic Brain Metastases Tianjin Medical University Cancer Institute and Hospital 74
Not applicableTemporarily pausedNCT06465537What this trial is testingCRISPR/Cas9 Instantaneous Gene Editing Therapy to Intraocular Hypertensive POAG With MYOC MutationWho this might be right forPrimary Open Angle Glaucoma Shanghai BDgene Co., Ltd. 9
Not applicableStudy completedNCT04236102What this trial is testingKEBI-Cyto Study - Use of the Biocartis IdyllaWho this might be right forPancreatic AdenocarcinomaLung Cancer Royal Cornwall Hospitals Trust 55
Not applicableUnknownNCT05087953What this trial is testingAutonomic Evaluation of Patients With Hereditary Amyloidotic Cardiomyopathy: Hereditary Amyloidotic Heart DiseaseWho this might be right forAutonomic Nervous System DiseaseAmyloid Neuropathies University of Sao Paulo General Hospital 60
Testing effectiveness (Phase 2)Study completedNCT00375219What this trial is testingHomoharringtonine (Omacetaxine Mepesuccinate) in Treating Patients With Chronic Myeloid Leukemia (CML) With the T315I BCR-ABL Gene MutationWho this might be right forChronic Myeloid Leukemia Teva Branded Pharmaceutical Products R&D, Inc. 103
Not applicableEnded earlyNCT01103128What this trial is testingValidation of a Mouse Model of Pancreatic CarcinogenesisWho this might be right forPancreatic Cancer Columbia University 450
Testing effectiveness (Phase 2)Study completedNCT01898312What this trial is testingBRCA1/2 and Effect of Mifepristone on the BreastWho this might be right forWomen With Mutations in the Breast Cancer Susceptibility Genes BRCA1,2 Karolinska Institutet 45
Not applicableStudy completedNCT03802812What this trial is testingThin Bronchoscope and Virtual Bronchoscopic Navigation System for TuberculosisWho this might be right forTuberculosis Pusan National University Hospital 88
Not applicableStudy completedNCT01783795What this trial is testingDent Disease Mutation GenotypingWho this might be right forDent Disease Mayo Clinic 180
Early research (Phase 1)Looking for participantsNCT06186401What this trial is testingAnti-EGFRvIII synNotch Receptor Induced Anti-EphA2/IL-13Ralpha2 CAR (E-SYNC) T CellsWho this might be right forEGFR Gene MutationGlioblastomaMGMT-Unmethylated Glioblastoma+1 more Hideho Okada, MD, PhD 20
Not applicableUnknownNCT05411276What this trial is testingA Real-World Study of Pyrotinib Maleate in the Treatment of Advanced/Metastatic Non-Small Cell Lung Cancer With Rare Mutations in HER2Who this might be right forHER2 Mutant Non-small Cell Lung Cancer Beijing Chest Hospital 15
Testing effectiveness (Phase 2)UnknownNCT06492850What this trial is testingGene Therapy for RPGR Gene Mutation-associated X-linked Retinitis PigmentosaWho this might be right forX-Linked Retinitis Pigmentosa (XLRP) Frontera Therapeutics 32
Not applicableLooking for participantsNCT07432880What this trial is testingA Prospective Study of Pediatric Participants up to 16 Years of Age With Methylmalonic Acidemia (MMA) Due to Mutations in the MMUT GeneWho this might be right forMethylmalonic Acidemia (MMA) Genespire Srl 30
Not applicableStudy completedNCT02047903What this trial is testingGIOTRIF in First Line Therapy of Advanced NSCLC With EGFR-mutationsWho this might be right forCarcinoma, Non-Small-Cell Lung Boehringer Ingelheim 161
Large-scale testing (Phase 3)Study completedNCT03293524What this trial is testingEfficacy & Safety Study of Bilateral IVT Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 YearWho this might be right forLeber Hereditary Optic Neuropathy GenSight Biologics 98
Testing effectiveness (Phase 2)Enrolling By InvitationNCT06275620What this trial is testingA Study Comparing Two Doses of AGTC-501 in Male Participants With X-linked Retinitis Pigmentosa Caused by RPGR Mutations (DAWN)Who this might be right forX-Linked Retinitis Pigmentosa Beacon Therapeutics 24