Crick
HomeTrialsGenesDrugs23andMeGraphBlogContact
  • Home
  • Trials
  • Genes
  • Drugs
  • 23andMe
  • Graph
  • Blog
  • Contact
Crick

An open-source clinical intelligence platform. Explore clinical trials, gene networks, and molecular structures using public data sources.

Data Sources

  • ClinicalTrials.gov
  • OpenTargets
  • ClinVar
  • PubChem

Links

  • Contact
  • Privacy

© 2026 Crick. All rights reserved.

Crick is for educational purposes only. Not medical advice.

Results for “Generalized Lipodystrophy”

28 trials

Filters

Phase
Early Phase 1
Phase 1
Phase 2
Phase 3
Phase 4
Status
Recruiting
Active, Not Recruiting
Not Yet Recruiting
Completed
Enrolling by Invitation

Showing 20 of 28 results

Large-scale testing (Phase 3)Active Not RecruitingNCT02262832
What this trial is testing

Compassionate Use of Metreleptin in Previously Treated People With Generalized Lipodystrophy

Who this might be right for
LipodystrophyDiabetesHyperlipidemia
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 24
Not applicableActive Not RecruitingNCT03936829
What this trial is testing

Cyclophosphamide in the Treatment of Associated Acquired Lipodystrophy Syndrome With Type 1 Diabetes

Who this might be right for
Lipodystrophy AcquiredType1diabetes
Children's Hospital of Fudan University 10
Large-scale testing (Phase 3)Looking for participantsNCT07220785
What this trial is testing

Efficacy and Safety of Mibavademab in Adult and Pediatric Patients With Generalized Lipodystrophy

Who this might be right for
Generalized Lipodystrophy
Regeneron Pharmaceuticals 28
Large-scale testing (Phase 3)UnknownNCT04221152
What this trial is testing

A Extension Study of Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance ( EMPIRE-02 )

Who this might be right for
Insulin Resistance - Type AInsulin Resistance - Type BLipoatrophic Diabetes Mellitus+1 more
Kobe University 8
Not applicableUnknownNCT00345280
What this trial is testing

Ocular Surface Changes in Patients With Cystic Fibrosis

Who this might be right for
Eye Manifestations
University of Bialystok 26
Not applicableLooking for participantsNCT06725940
What this trial is testing

GzmB-PET/CT to Evaluate Neoadjuvant Therapy Efficacy in Breast Cancer

Who this might be right for
Breast Cancer Invasive
Shanghai Jiao Tong University School of Medicine 50
Post-approval studies (Phase 4)Study completedNCT04026178
What this trial is testing

Immunogenicity of Metreleptin in Patients With Generalized Lipodystrophy

Who this might be right for
Generalized Lipodystrophy
Aegerion Pharmaceuticals, Inc. 11
Not applicableNot Yet RecruitingNCT06863441
What this trial is testing

The Value of PET Imaging Targeting Granzyme B in Predicting Efficacy and Prognosis in T-NK Cell Lymphoma

Who this might be right for
T-NK Cell Lymphoma
Ruijin Hospital 50
Testing effectiveness (Phase 2)Study completedNCT05000372
What this trial is testing

68Ga-grazytracer PET/CT of Tumor Responses to Immunotherapy

Who this might be right for
Cancer
Peking University Cancer Hospital & Institute 24
Large-scale testing (Phase 3)Ended earlyNCT06502990
What this trial is testing

Open-label Study to Evaluate Metreleptin in Children Under 6 Years of Age With Generalised Lipodystrophy

Who this might be right for
Generalized Lipodystrophy
Amryt Pharma 1
Large-scale testing (Phase 3)Study completedNCT06548100
What this trial is testing

The Safety of Mibavademab in Pediatric and Adult Participants Switching From Metreleptin to Mibavademab for the Treatment of Generalized Lipodystrophy (GLD)

Who this might be right for
Generalized Lipodystrophy
Regeneron Pharmaceuticals 9
Testing effectiveness (Phase 2)Study completedNCT03514420
What this trial is testing

Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL)

Who this might be right for
Familial Partial Lipodystrophy
Akcea Therapeutics 4
Post-approval studies (Phase 4)Study completedNCT03344159
What this trial is testing

Spironolactone Therapy in Chronic Stable Right HF Trial

Who this might be right for
Chronic Right-Sided Heart FailurePulmonary Arterial HypertensionPulmonary Hypertension, Primary, 2+3 more
Ottawa Heart Institute Research Corporation 15
Testing effectiveness (Phase 2)Study completedNCT00025883
What this trial is testing

Leptin to Treat Lipodystrophy

Who this might be right for
Lipodystrophy
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) 103
Large-scale testing (Phase 3)UnknownNCT04018365
What this trial is testing

Empagliflozin in Patients With Refractory Diabetes Mellitus With Insulin Resistance

Who this might be right for
Insulin Resistance - Type AInsulin Resistance - Type BLipoatrophic Diabetes Mellitus+1 more
Kobe University 8
Testing effectiveness (Phase 2)Looking for participantsNCT05888532
What this trial is testing

64Cu-GRIP B in Patients With Advanced Malignancies

Who this might be right for
Prostate CancerRenal CancerUrethral Cancer+3 more
Rahul Aggarwal 91
Testing effectiveness (Phase 2)Study completedNCT04159415
What this trial is testing

Study of REGN4461, a Leptin Receptor Agonist Antibody, in Patients With Generalized Lipodystrophy

Who this might be right for
Generalized Lipodystrophy
Regeneron Pharmaceuticals 16
Not applicableAvailableNCT04710056
What this trial is testing

Expanded Access to REGN4461 for Patients With Diseases Associated With Deficient Leptin Signaling

Who this might be right for
LipodystrophyGeneralized Lipodystrophy (GLD)Monogenic Obesity (MOB)
Regeneron Pharmaceuticals
Not applicableStudy completedNCT06982053
What this trial is testing

[68Ga]Ga-GZP PET for Early Response Prediction in Colorectal Cancer During Neoadjuvant Therapy

Who this might be right for
Colorectal Cancer Control and PreventionColorectal Cancer RecurrentColorectal Cancer Metastatic+1 more
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology 21
Large-scale testing (Phase 3)Study completedNCT00896298
What this trial is testing

Trial of Leptin Replacement Therapy in Patients With Lipodystrophy

Who this might be right for
HypoleptinemiaGeneralized LipodystrophyPartial Lipodystrophy+1 more
University of Texas Southwestern Medical Center 25
Next Page