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Results for “Germline Mutation”

144 trials

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Showing 20 of 144 results

Testing effectiveness (Phase 2)Study completedNCT01967576
What this trial is testing

Phase II Study of Axitinib (AG-013736) With Evaluation of the VEGF-pathway in Metastatic, Recurrent or Primary Unresectable Pheochromocytoma/Paraganglioma

Who this might be right for
PheochromocytomaParaganglioma
National Cancer Institute (NCI) 14
Large-scale testing (Phase 3)Study completedNCT02184195
What this trial is testing

Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy

Who this might be right for
Germline BRCA1/2 Mutations andMetastatic Adenocarcinoma of the Pancreas
AstraZeneca 154
Not applicableUnknownNCT04983628
What this trial is testing

Molecular Profiling in Prostate Cancer

Who this might be right for
Prostate Cancer MetastaticProstate Cancer RecurrentGermline BRCA1 Gene Mutation+2 more
Hellenic Cooperative Oncology Group 250
Not applicableLooking for participantsNCT02302742
What this trial is testing

Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

Who this might be right for
Breast CancerHereditary Breast and Ovarian Cancer
University of Kansas Medical Center 1,500
Not applicableUnknownNCT02207686
What this trial is testing

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Who this might be right for
Von Hippel-Lindaus Disease
Marie Luise Bisgaard, MD 50
Not applicableLooking for participantsNCT07019155
What this trial is testing

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

Who this might be right for
Germline MutationMyelodysplastic SyndromesAcute Myeloid Leukemia
National Cancer Institute (NCI) 510
Testing effectiveness (Phase 2)Looking for participantsNCT05485766
What this trial is testing

Novel Neoadjuvant and Adjuvant Strategy for Germline BRCA 1/2 Mutated Triple Negative Breast Cancer

Who this might be right for
Triple Negative Breast NeoplasmsTriple Negative Breast CancerBreast Neoplasms+5 more
Okayama University 23
Testing effectiveness (Phase 2)Ended earlyNCT02326844
What this trial is testing

BMN 673 (Talazoparib), an Oral PARP Inhibitor, in People With Deleterious BRCA1/2 Mutation-Associated Ovarian Cancer Who Have Had Prior PARP Inhibitor Treatment

Who this might be right for
Ovarian Cancer
National Cancer Institute (NCI) 3
Early research (Phase 1)Ended earlyNCT04770246
What this trial is testing

TAS-117 in Patients With Advanced Solid Tumors Harboring Germline PTEN Mutations

Who this might be right for
Advanced or Metastatic Solid Tumors Irrespective of Gene AlterationsAdvanced or Metastatic Solid Tumors With Germline PTEN Inactivating Mutations
Taiho Oncology, Inc. 17
Not applicableUnknownNCT04368442
What this trial is testing

Cohort Study of Patients With HER2-negative MBC and BRCA 1/2 Pathogenic Mutation

Who this might be right for
Breast Cancer Metastatic
Samsung Medical Center 583
Testing effectiveness (Phase 2)Not Yet RecruitingNCT07353437
What this trial is testing

Fluzoparib as Adjuvant Treatment in Patients With Germline Homologous Recombination Repair (HRR) Mutated Primary Breast Cancer (Flamenco)

Who this might be right for
Breast Cancer
Fudan University 334
Not applicableLooking for participantsNCT06886672
What this trial is testing

Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE VariaTionS

Who this might be right for
Mesothelioma, Malignant Pleural
Fondazione IRCCS Policlinico San Matteo di Pavia 60
Testing effectiveness (Phase 2)Study completedNCT04240106
What this trial is testing

Niraparib Plus Aromatase Inhibitors for Luminal-like(HER2-,ER+) and gBRCA or HDR+ Metastatic Breast Cancer (LUZERN)

Who this might be right for
Breast CancerBreast Cancer Metastatic
MedSIR 14
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05232006
What this trial is testing

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers

Who this might be right for
Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Assistance Publique - Hôpitaux de Paris 12
Not applicableStudy completedNCT00342797
What this trial is testing

Retinoblastoma Biomarker Study

Who this might be right for
RetinoblastomaMelanomaSarcoma
National Cancer Institute (NCI) 2,136
Large-scale testing (Phase 3)Looking for participantsNCT06533384
What this trial is testing

PARPi or Capecitabine Combined With PD-1 Inhibitors as Adjuvant Therapy in High-risk TNBC

Who this might be right for
Triple-negative Breast Cancer
Guangdong Provincial People's Hospital 310
Large-scale testing (Phase 3)Study completedNCT03402841
What this trial is testing

Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients

Who this might be right for
Non-Germline BRCA Mutated Ovarian Cancer
AstraZeneca 279
Not applicableLooking for participantsNCT04903782
What this trial is testing

Cancer Predisposition Testing by Family-based Whole-genome Sequencing (WGS) in Every Child With Newly Diagnosed Cancer

Who this might be right for
Neoplastic Syndromes, HereditaryCancerGenetic Predisposition to Disease
Sydney Children's Hospitals Network 270
Not applicableLooking for participantsNCT05983991
What this trial is testing

Study for Characterisation of Predictive Parameters of Clonal Evolution in Subjects With GATA2 Germline Mutation

Who this might be right for
GATA2 Gene Mutation
Institut Claudius Regaud 150
Not applicableStudy completedNCT05721326
What this trial is testing

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

Who this might be right for
Genetic Predisposition to DiseaseBreast Cancer FemaleOvarian Cancer+4 more
Abramson Cancer Center at Penn Medicine 1,330
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