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Results for “Germline Mutation”

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Showing 20 of 0 results

Large-scale testing (Phase 3)Study completedNCT03402841
What this trial is testing

Multicentre Study of Olaparib Maintenance Monotherapy in Platinum Sensitive Relapsed Non gBRCAm Ovarian Cancer Patients

Who this might be right for
Non-Germline BRCA Mutated Ovarian Cancer
AstraZeneca 279
Not applicableLooking for participantsNCT02280161
What this trial is testing

Germ-Line Mutations in Blood and Saliva Samples From Patients With Cancer

Who this might be right for
Malignant Neoplasm
Jonsson Comprehensive Cancer Center 2,000
Testing effectiveness (Phase 2)Study completedNCT00971789
What this trial is testing

Sirolimus to Treat Cowden Syndrome and Other PTEN Hamartomatous Tumor Syndromes

Who this might be right for
Cowden's DiseaseHamartoma Syndrome, Multiple
National Cancer Institute (NCI) 18
Not applicableUnknownNCT03092128
What this trial is testing

A Retrospective Pharmacokinetics and Pharmacogenomics Research of Imatinib in Gastrointestinal Stromal Tumor Treatment

Who this might be right for
Gastrointestinal Stromal TumorsGermline MutationSomatic Mutation+1 more
Xueding Wang 200
Not applicableUnknownNCT02207686
What this trial is testing

Assessment of Residual VHL Function in Tumors - Can it Predict the Patients' Individual Course of Disease?

Who this might be right for
Von Hippel-Lindaus Disease
Marie Luise Bisgaard, MD 50
Not applicableStudy completedNCT02823652
What this trial is testing

Pre-Test Genetic Education and Remote Genetic Counseling in Communicating Tumor Profiling Results to Patients With Advanced Cancer

Who this might be right for
Advanced Malignant NeoplasmLocally Advanced Malignant Neoplasm
ECOG-ACRIN Cancer Research Group 601
Not applicableStudy completedNCT05721326
What this trial is testing

Sequential EHR Based Interventions to Increase Genetic Testing for Breast and Ovarian Cancer Predisposition

Who this might be right for
Genetic Predisposition to DiseaseBreast Cancer FemaleOvarian Cancer+4 more
Abramson Cancer Center at Penn Medicine 1,283
Not applicableEnded earlyNCT04436120
What this trial is testing

Treatment Resistance Following Anti-cancer Therapies

Who this might be right for
Disease Progression
Pfizer 38
Testing effectiveness (Phase 2)Looking for participantsNCT05960773
What this trial is testing

Decitabine/Cedazuridine (INQOVI), an Oral DNA Demethylating Agent, in Subjects With BAP1 Cancer Predisposition Syndrome and Subclinical, Early-Stage Mesothelioma

Who this might be right for
MesotheliomaMalignant Mesothelioma (MM)Early-stage Mesothelioma+3 more
National Cancer Institute (NCI) 15
Testing effectiveness (Phase 2)WithdrawnNCT03933761
What this trial is testing

Pamiparib in Fusion Positive, Reversion Negative High Grade Serous Ovarian Cancer or Carcinosarcoma With BRCA1/2 Gene Mutations If Progression on Substrate Poly ADP Ribose Polymerase Inhibitbor (PARPI) or Chemotherapy

Who this might be right for
Ovarian CancerCarcinosarcoma
Australia New Zealand Gynaecological Oncology Group
Not applicableLooking for participantsNCT07019155
What this trial is testing

Study of Individuals and Families With Aberrations in DDX41 or Similar Cancer Predisposition Variants

Who this might be right for
Germline MutationMyelodysplastic SyndromesAcute Myeloid Leukemia
National Cancer Institute (NCI) 510
Not applicableNot Yet RecruitingNCT06726330
What this trial is testing

Risk-reducing Strategies, Including Fimbriectomy, in Women With a Germline Mutation Predisposing to Ovarian or Pelvic Cancer

Who this might be right for
Tubo-ovarian CarcinomaHigh-grade Serous CarcinomaPrimary Peritoneal Carcinoma Stage III+2 more
Centre Oscar Lambret 1,100
Large-scale testing (Phase 3)Not Yet RecruitingNCT07218575
What this trial is testing

Double-Blind Trial of Everolimus for Improving Social Abilities in PTEN Germline Mutations

Who this might be right for
Cowden's DiseaseCowden's SyndromeLhermitte-Duclos Disease+6 more
Boston Children's Hospital 60
Not applicableLooking for participantsNCT07436312
What this trial is testing

Impact of Consumption of Ultra-processed Foods in Individuals at High Risk of Cancer

Who this might be right for
Breast CancerPancreas CancerColon Cancer+3 more
Gustave Roussy, Cancer Campus, Grand Paris 170
Testing effectiveness (Phase 2)Study completedNCT02889900
What this trial is testing

Efficacy and Safety Study of Cediranib in Combination With Olaparib in Patients With Recurrent Platinum-Resistant Ovarian Cancer

Who this might be right for
Recurrent Platinum Resistant Ovarian Cancer
AstraZeneca 62
Not applicableStudy completedNCT02608346
What this trial is testing

Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)

Who this might be right for
Women With BRCA1 Germline Deleterious Mutation
Institut Curie 200
Not applicableLooking for participantsNCT06886672
What this trial is testing

Genetic Susceptibility in MAlignant Pleural Mesothelioma: Clinical Implication of GermliNE variaTionS

Who this might be right for
Mesothelioma, Malignant Pleural
Fondazione IRCCS Policlinico San Matteo di Pavia 60
Not applicableLooking for participantsNCT02302742
What this trial is testing

Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

Who this might be right for
Breast CancerHereditary Breast and Ovarian Cancer
University of Kansas Medical Center 3,000
Not applicableNot Yet RecruitingNCT06923670
What this trial is testing

Prevalence Of Germline Gene Mutations In Patients With Myeloproliferative Neoplasms With Family History

Who this might be right for
Polycythemia VeraEssential ThrombocythaemiaMyelofibrosis
Fondazione Policlinico Universitario Agostino Gemelli IRCCS 496
Early research (Phase 1)Looking for participantsNCT07069335
What this trial is testing

A Bioequivalence Study to Evaluate Pharmacokinetics and Safety of BR2022 and BR2022-1 in Patients With Deleterious or Suspected Deleterious Germline BRCA-Mutated Advanced Ovarian Cancer

Who this might be right for
Ovarian Cancer
Boryung Pharmaceutical Co., Ltd 24
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