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Results for “Germline Mutations”

139 trials

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Showing 20 of 139 results

Testing effectiveness (Phase 2)UnknownNCT02681562
What this trial is testing

Olaparib in Locally Advanced ER, PgR and HER2 Negative (Triple Negative) and in Locally Advanced Germline BRCA Mutation-positive Breast Cancer Patients

Who this might be right for
Breast CancerTriple Negative Breast Cancer
Istituti Ospitalieri di Cremona 45
Not applicableLooking for participantsNCT07498829
What this trial is testing

Population Based Germline Testing for Early Detection and Prevention of Cancer

Who this might be right for
Breast Cancer RiskOvarian Cancer RiskCancer Gene Mutation
Queen Mary University of London 6,000
Not applicableStudy completedNCT01556399
What this trial is testing

Endoscopic Characteristics of Duodenal and Ampullary Lesions

Who this might be right for
Duodenal Diseases
Professor Michael Bourke 350
Not applicableEnded earlyNCT04668521
What this trial is testing

Multifactorial Risk Assessment for Breast & Ovarian Cancer Risk Detection

Who this might be right for
Adnexal MassGermline BRCA1 Gene MutationGermline BRCA2 Gene Mutation+1 more
Aspira Women's Health 215
Not applicableStudy completedNCT04683068
What this trial is testing

Promoting Men's Adherence to BRCA1/2 Germline Genetic Testing

Who this might be right for
BRCA1 MutationBRCA2 MutationPsychosocial Factors
European Institute of Oncology 264
Not applicableLooking for participantsNCT05072483
What this trial is testing

Natural History Study of CADASIL

Who this might be right for
Cardiovascular DiseaseArterial StiffnessGermline Mutation in the NOTCH 3 Gene+2 more
National Heart, Lung, and Blood Institute (NHLBI) 155
Not applicableStudy completedNCT00482872
What this trial is testing

Germline Mutations in Patients With Head and Neck Cancer and a Family History of Cancer

Who this might be right for
Head and Neck Cancer
Vanderbilt University Medical Center 400
Not applicableActive Not RecruitingNCT03246841
What this trial is testing

Investigation of Tumour Spectrum of Germline Mutations in Breast and Ovarian Cancer Genes.

Who this might be right for
Hereditary Breast and Ovarian CancerMutation
UNICANCER 7,274
Not applicableStudy completedNCT04206891
What this trial is testing

CDH1 Germline Mutations in Lobular Breast Cancer

Who this might be right for
Lobular Breast CarcinomaCDH1 Gene Inactivation
European Institute of Oncology 421
Not applicableEnded earlyNCT02566161
What this trial is testing

Parental Irradiation of Ukrainian Cleanup Workers and Evacuees and Germline Mutations in Their Offspring (Trio Study)

Who this might be right for
Genetics
National Cancer Institute (NCI) 957
Not applicableLooking for participantsNCT04995198
What this trial is testing

PROMISE Registry: A Prostate Cancer Registry of Outcomes and Germline Mutations for Improved Survival and Treatment Effectiveness

Who this might be right for
Prostate Cancer
Prostate Cancer Clinical Trials Consortium 500
Not applicableStudy completedNCT03030404
What this trial is testing

Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

Who this might be right for
Stomach NeoplasmsStomach CancerGastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)+2 more
National Cancer Institute (NCI) 733
Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Not applicableStudy completedNCT00582803
What this trial is testing

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 85
Not applicableWithdrawnNCT01372696
What this trial is testing

Endoscopic Characteristics of Colonic Tumours

Who this might be right for
Colonic PolypColon Cancer
Professor Michael Bourke
Not applicableNot Yet RecruitingNCT06895681
What this trial is testing

UCSF Biobank for Hereditary Cancers and Tumor-Associated Mutations

Who this might be right for
Solid TumorSolid Tumor, AdultSomatic Mutation+2 more
University of California, San Francisco 50,000
Not applicableStudy completedNCT04160832
What this trial is testing

Prevalence and Spectrum of Cancer Susceptibility Among Patients with Advanced Colorectal Polyps

Who this might be right for
Colorectal Neoplasm
University of Colorado, Denver 200
Testing effectiveness (Phase 2)Study completedNCT02789332
What this trial is testing

Assessing the Efficacy of Paclitaxel and Olaparib in Comparison to Paclitaxel / Carboplatin Followed by Epirubicin/Cyclophosphamide as Neoadjuvant Chemotherapy in Patients With HER2-negative Early Breast Cancer and Homologous Recombination Deficiency

Who this might be right for
Breast CancerTriple Negative Breast NeoplasmsHRpos Breast Neoplasms+1 more
GBG Forschungs GmbH 107
Not applicableLooking for participantsNCT02302742
What this trial is testing

Triple Negative Breast Cancer and Germline Hereditary Breast and Ovarian Cancer Mutation Carrier Registry

Who this might be right for
Breast CancerHereditary Breast and Ovarian Cancer
University of Kansas Medical Center 1,500
Not applicableLooking for participantsNCT01994057
What this trial is testing

A Retrospective Study of EGFR-TKIs,Gefitinib, Erlotinib and Osimertinib in NSCLC Patients Treatment

Who this might be right for
Non-small Cell Lung Cancer (NSCLC)EGFR-TKI Resistant MutationEGFR-TKI Sensitizing Mutation+2 more
Sun Yat-sen University 1,000
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