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Results for “Germline Mutations”

135 trials

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Showing 20 of 135 results

Testing effectiveness (Phase 2)Ended earlyNCT04171700
What this trial is testing

Evaluate Rucaparib in Participants With Solid Tumors and With Deleterious Mutations in HRR Genes

Who this might be right for
Solid Tumor
pharmaand GmbH 83
Not applicableStudy completedNCT01773655
What this trial is testing

Clinical and Histopathologic Characteristics of BAP1 Mutations

Who this might be right for
Malignant Pleural Mesothelioma (MPM)Choroidal NevusPrimary Uveal Melanoma (UM)+3 more
Memorial Sloan Kettering Cancer Center 196
Testing effectiveness (Phase 2)Not Yet RecruitingNCT05232006
What this trial is testing

PARP-inhibitor on Advanced Metastatic Breast Cancer in Germline PALB2 Mutations Carriers

Who this might be right for
Metastatic Breast Cancer in Germline-PALB2 Mutations Carriers
Assistance Publique - Hôpitaux de Paris 12
Not applicableStudy completedNCT02823652
What this trial is testing

Pre-Test Genetic Education and Remote Genetic Counseling in Communicating Tumor Profiling Results to Patients With Advanced Cancer

Who this might be right for
Advanced Malignant NeoplasmLocally Advanced Malignant Neoplasm
ECOG-ACRIN Cancer Research Group 601
Not applicableActive Not RecruitingNCT01754025
What this trial is testing

INHERIT EGFR - Studying Germline EGFR Mutations

Who this might be right for
Lung Cancer
Dana-Farber Cancer Institute 121
Not applicableStudy completedNCT04160832
What this trial is testing

Prevalence and Spectrum of Cancer Susceptibility Among Patients with Advanced Colorectal Polyps

Who this might be right for
Colorectal Neoplasm
University of Colorado, Denver 200
Not applicableLooking for participantsNCT03830229
What this trial is testing

Long Term Follow-up of Mesothelioma Patients and Their Family Members With Germline Mutations in BAP1 and Other Genes

Who this might be right for
MesotheliomaFamilies
National Cancer Institute (NCI) 1,000
Not applicableActive Not RecruitingNCT03857594
What this trial is testing

Integrative Sequencing In Germline and Hereditary Tumours

Who this might be right for
Hereditary Cancer SyndromeHigh-RiskMutation+1 more
University Health Network, Toronto 10
Testing effectiveness (Phase 2)UnknownNCT04940637
What this trial is testing

UNITO-001- Study in HRR/PDL1 Positive MPM/NSCLC

Who this might be right for
Lung CancerMesothelioma
University of Turin, Italy 70
Not applicableLooking for participantsNCT05072483
What this trial is testing

Natural History Study of CADASIL

Who this might be right for
Cardiovascular DiseaseArterial StiffnessGermline Mutation in the NOTCH 3 Gene+2 more
National Heart, Lung, and Blood Institute (NHLBI) 155
Testing effectiveness (Phase 2)Active Not RecruitingNCT04053322
What this trial is testing

Durvalumab, With Olaparib and Fulvestrant in Advanced ER+, HER2- Breast Cancer Patients.

Who this might be right for
ER-positive and HER2-negative Metastatic or Locally Advanced Breast Cancera Germline or Somatic BRCA Mutation, or a Deleterious Alteration of Other Genes Involved in Homologous Recombination Repair (HRR) or in MSI Status
UNICANCER 172
Testing effectiveness (Phase 2)Active Not RecruitingNCT03344965
What this trial is testing

Olaparib In Metastatic Breast Cancer

Who this might be right for
Metastatic Breast CancerInvasive Breast CancerSomatic Mutation Breast Cancer (BRCA1)+7 more
Beth Israel Deaconess Medical Center 114
Not applicableStudy completedNCT02821780
What this trial is testing

CADASIL Disease Discovery

Who this might be right for
Germline Mutation in the NOTCH 3 GeneCardiovascular DiseaseArterial Stiffness+2 more
National Heart, Lung, and Blood Institute (NHLBI) 20
Large-scale testing (Phase 3)Study completedNCT03286842
What this trial is testing

To Study Clinical Effectiveness and Safety of Olaparib Monotherapy in Metastatic Breast Cancer Patients.

Who this might be right for
HER2-ve Metastatic Breast CancerGermline BRCA1/2 MutationsSomatic BRCA1/2 Mutations
AstraZeneca 256
Early research (Phase 1)Looking for participantsNCT04890613
What this trial is testing

Study of CX-5461 in Patients With Solid Tumours and BRCA1/2, PALB2 or Homologous Recombination Deficiency (HRD) Mutation

Who this might be right for
Advanced Solid Tumor
Senhwa Biosciences, Inc. 52
Large-scale testing (Phase 3)Study completedNCT02184195
What this trial is testing

Olaparib in gBRCA Mutated Pancreatic Cancer Whose Disease Has Not Progressed on First Line Platinum-Based Chemotherapy

Who this might be right for
Germline BRCA1/2 Mutations andMetastatic Adenocarcinoma of the Pancreas
AstraZeneca 154
Testing effectiveness (Phase 2)Looking for participantsNCT04090567
What this trial is testing

Olaparib With Cediranib or AZD6738 for the Treatment of Advanced or Metastatic Germline BRCA Mutated Breast Cancer

Who this might be right for
Advanced Breast CarcinomaAnatomic Stage III Breast Cancer AJCC v8Anatomic Stage IIIA Breast Cancer AJCC v8+12 more
M.D. Anderson Cancer Center 60
Testing effectiveness (Phase 2)Ended earlyNCT03140670
What this trial is testing

Maintenance Rucaparib in BRCA1, BRCA2 or PALB2 Mutated Pancreatic Cancer That Has Not Progressed on Platinum-based Therapy

Who this might be right for
Pancreatic Cancer
Abramson Cancer Center at Penn Medicine 46
Not applicableStudy completedNCT00582803
What this trial is testing

Adherence to Intensive Surveillance for Hereditary Breast Cancer

Who this might be right for
Breast Cancer
Memorial Sloan Kettering Cancer Center 85
Not applicableLooking for participantsNCT07204392
What this trial is testing

Unveiling the Germline Predisposition to Myeloproliferative Neoplasms

Who this might be right for
Myeloproliferative DiseaseGermline Mutation
Fondazione IRCCS Policlinico San Matteo di Pavia 313
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