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Results for “Hemoglobinuria, Paroxysmal”

187 trials

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Showing 20 of 187 results

Large-scale testing (Phase 3)Study completedNCT05630001
What this trial is testing

Single Arm, Open Label Trial With Iptacopan Treatment for 24 Weeks, in Patients on Stable Regimen of Anti-C5 Who Switch to Iptacopan.

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Novartis Pharmaceuticals 52
Large-scale testing (Phase 3)Study completedNCT06799546
What this trial is testing

A Phase III Study to Evaluate the Efficacy and Safety of HSK39297 in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
PNH
Haisco Pharmaceutical Group Co., Ltd. 73
Testing effectiveness (Phase 2)Study completedNCT00004464
What this trial is testing

Study of High Dose Cyclophosphamide in Patients With Severe Aplastic Anemia and Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Aplastic AnemiaParoxysmal Hemoglobinuria, Nocturnal
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins 69
Testing effectiveness (Phase 2)Study completedNCT02352493
What this trial is testing

An Investigational Drug, ALN-CC5, in Healthy Adult Volunteers and Patients With PNH

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Alnylam Pharmaceuticals 62
Large-scale testing (Phase 3)Study completedNCT04820530
What this trial is testing

Study of Efficacy and Safety of Twice Daily Oral Iptacopan (LNP023) in Adult PNH Patients Who Are Naive to Complement Inhibitor Therapy

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Novartis Pharmaceuticals 40
Large-scale testing (Phase 3)Study completedNCT06715943
What this trial is testing

Efficacy and Safety of HRS-5965 in Patients With PNH Who Are Still Anemia After Anti-C5 Antibody Treatment

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Chengdu Suncadia Medicine Co., Ltd. 39
Not applicableActive Not RecruitingNCT07413679
What this trial is testing

Long-term Safety of Danicopan: IPIG Registry-based Cohort Study

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaPNH
Alexion Pharmaceuticals, Inc. 50
Not applicableActive Not RecruitingNCT06903234
What this trial is testing

Post-authorization Safety Study of Iptacopan in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Using Data From the IPIG PNH Registry

Who this might be right for
Hemoglobinuria, Paroxysmal
Novartis Pharmaceuticals 200
Large-scale testing (Phase 3)Study completedNCT03056040
What this trial is testing

ALXN1210 Versus Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Alexion Pharmaceuticals, Inc. 202
Large-scale testing (Phase 3)Study completedNCT06578949
What this trial is testing

Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of Ravulizumab in Chinese Adults Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaPNH
Alexion Pharmaceuticals, Inc. 18
Testing effectiveness (Phase 2)Looking for participantsNCT07187401
What this trial is testing

A First-in-Human Safety and Efficacy Study of ALN-CFB, a Small Interfering RNA (siRNA) Targeting Complement Factor B, in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria With Persistent Anemia on a C5 Inhibitor

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)Persistent Anemia
Regeneron Pharmaceuticals 24
Large-scale testing (Phase 3)Study completedNCT03748823
What this trial is testing

Ravulizumab Subcutaneous (SC) Versus Ravulizumab Intravenous (IV) in Adults With Paroxysmal Nocturnal Hemoglobinuria (PNH) Currently Treated With Eculizumab

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 139
Testing effectiveness (Phase 2)Ended earlyNCT04702568
What this trial is testing

A Long-Term Safety Study of BCX9930 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal HemoglobinuriaPNH
BioCryst Pharmaceuticals 19
Not applicableActive Not RecruitingNCT06633536
What this trial is testing

Real-life Treatment Outcomes of Ravulizumab in PNH

Who this might be right for
Paroxysmal Nocturnal Haemoglobinuria
AstraZeneca 64
Testing effectiveness (Phase 2)Study completedNCT03181633
What this trial is testing

A Long-Term Treatment Study of ACH-0144471 in Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 8
Large-scale testing (Phase 3)Study completedNCT05886244
What this trial is testing

Eculizumab in Adult Participants With Paroxysmal Nocturnal Hemoglobinuria (PNH) in China

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Alexion Pharmaceuticals, Inc. 25
Testing effectiveness (Phase 2)Study completedNCT00566696
What this trial is testing

Mismatched Family Member Donor Transplantation for Children and Young Adults With High Risk Hematological Malignancies

Who this might be right for
Leukemia, Acute Lymphocytic (ALL)Leukemia, Myeloid, Acute(AML)Leukemia, Myeloid, Chronic(CML)+5 more
St. Jude Children's Research Hospital 73
Not applicableLooking for participantsNCT07229235
What this trial is testing

REAL-CARE: Real-world Effectiveness of Iptacopan in Italian Patients With Paroxysmal Nocturnal Hemoglobinuria

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria (PNH)
Novartis Pharmaceuticals 50
Not applicableEnded earlyNCT02179359
What this trial is testing

Hematopoietic Stem Cell Transplant for High Risk Hemoglobinopathies

Who this might be right for
Sickle Cell DiseaseTransfusion Dependent Alpha- or Beta- ThalassemiaDiamond Blackfan Anemia+5 more
Masonic Cancer Center, University of Minnesota 38
Testing effectiveness (Phase 2)Study completedNCT06050226
What this trial is testing

MY008211A in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH)

Who this might be right for
Paroxysmal Nocturnal Hemoglobinuria
Wuhan Createrna Science and Technology Co., Ltd 34
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